摘要：Theranostic nanosystems that integrate diagnosis and therapy have garnered increasing attention for personalized *** integration of the versatile nanoparticles to fabricate self-assembled theranostic nanomedicines becomes increasingly important in current medical *** silica nanoparticles(MSN)with their highly attractive physicochemical properties and favorable morphological attributes represent ideal templates for the controlled assembly and integration of functional nanomaterials to fabricate self-assembled theranostic *** rationally designed combination strategy and heterostructure will improve the overall bioavailability and preserve the unique property of each *** this review,the cutting-edge strategies for the designed fabrication of MSN-templated self-assembled nanomedicines are *** categorize MSN-based nanomedicines by their unique heterostructures,including core-shell,yolk-shell,core-satellite,heterodimer and core-shell-satellite structures,and discuss the controlled assembly approaches as well as the intriguing applications for disease ***,a perspective on the challenges in the clinical translation of self-assembled theranostic nanomedicines is highlighted.