摘要：Due to their special anatomical and physiological features,central nervous system diseases still presented challenges,despite the fact that some advances have been made in early diagnosis and precision *** of the complexities in treating tumors is the tumor microenvironment,which includes mesenchymal stem cells(MSCs)that exhibit tumor tropism and can be used for cell ***,whether MSCs promote or suppress gliomas is still unclear,especially in glioma *** this study,a coaxial microfiber was designed to mimic the tumor microenvironment and to reveal the effect of MSCs on glioma *** fiber shell was composed of MSCs and alginate,and the core was filled with U87 MG(glioblastoma)cells and gelatin *** Shell-MSC/Core-U87 MG microenvironment improved the proliferation,survival,invasion,metastasis,and drug resistance of glioma cells,while simultaneously maintaining the stemness of glioma *** summary,coaxial extrusion bioprinted Shell-MSC/Core-U87 MG microfiber is an ideal platform for tumor and stromal cell coculture to observe tumor biological behavior in vitro.

摘要：The need for reducing the wear in mechanical parts used in the industry makes self-lubricant films one of the sustainable solutions to achieve long-term protection under different environmental *** purpose of this work is to study the influence of C additions on the tribological behavior of a magnetron-sputtered TiN film in air,water,and *** results show that the addition of C into the TiN binary film induced a new amorphous phase,and the films exhibited a dual phase of fcc(face-centered cubic)-TiN and amorphous *** antifriction and wear-resistance properties were enhanced in air and water by adding 19.1at%***,a further increase in the C concentration improved anti-frictional properties but also led to higher wear *** the amorphous phase induced microbatteries and accelerated the corrosion of TiN phases in seawater,the negative abrasion state was detected for all Ti-C-N films due to the adhesion of the tribocorrosion debris on the wear track.

摘要：Sweat,as a biofluid with the potential for noninvasive collection,provides profound insights into human health conditions,because it contains various chemicals and information to be utilized for the monitoring of well-being,stress levels,exercise,and ***,wearable sweat sensors have been developed as a promising substitute to conventional laboratory sweat detection *** sensors are promising to realize low-cost,real-time,in situ sweat measurements,and provide great opportunities for health status evaluation analysis based on personalized big *** review first presents an overview of wearable sweat sensors from the perspective of basic components,including materials and structures for specific sensing applications and *** strategies and specific methods of the fabrication of wearable power management are also ***,current challenges and future directions of wearable sweat sensors are discussed.

摘要：The significance of bioink suitability for the extrusion bioprinting of tissue-like constructs cannot be ***,derived from the hydrolysis of collagen,not only can mimic the extracellular matrix to immensely support cell function,but also is suitable for extrusion under certain ***,gelatin has been recognized as a promising bioink for extrusion ***,the development of a gelatin-based bioink with satisfactory printability and bioactivity to fabricate complex tissue-like constructs with the desired physicochemical properties and biofunctions for a specific biomedical application is still in its ***,in this review,we aim to comprehensively summarize the state-of-the-art methods of gelatin-based bioink application for extrusion ***firstly outline the properties and requirements of gelatin-based bioinks for extrusion bioprinting,highlighting the strategies to overcome their main limitations in terms of printability,structural stability and cell ***,the challenges and prospects are further discussed regarding the development of ideal gelatin-based bioinks for extrusion bioprinting to create complex tissue-like constructs with preferable physicochemical properties and biofunctions.

摘要：在 CDQ (科克干燥熄灭) 柄，有复杂结构的发泄帽子在冷却室下面在锥形的漏斗被安装。它行动介绍冷却气体并且在房间支持下降焦炭。设计和发泄帽子目的安装，到得到相对一致的煤气的分发在插头减少焦炭的温度变化并且认识到 CDQ 的稳定的操作仪器。在这篇论文，在 1:7 规模 CDQ 试验性的柄的发泄帽子的气体的狂暴的流动被使用 CFD (计算液体动力学) 数字地模仿软件， CFX。速度地，插头流动分发和在三种发泄帽子(叫的高发泄帽子，低发泄帽子和椭圆形的发泄帽子) 下面的每个插头的压力落下因素被分析并且比较。结果生产椭圆形的发泄帽子的压力落下因素比另外的二发泄帽子大，并且高发泄帽子和低发泄帽子的压力落下因素几乎有一样的价值。当时为一顶指定发泄帽子，没有压，有压砖的压力落下因素比那大砖。在这篇论文的工作为为大规模 CDQ 柄设计发泄帽子是珍贵的。

摘要：本文提出了一种基于物理信息的神经网络(PINN)框架来分析在Winkler-Pasternak基础上的三维功能梯度FG多孔细长梁的非线性屈曲行为.使用简单的网络,PINNs只需要很少的训练数据来获得较高的精度.在这项工作中使用的强大工具可以处理任何类型的偏微分方程.我们使用深度学习平台TensorFlow和DeepXDE库来设计我们的网络.在本研究中,PINNs框架从梁系统的控制微分方程和边界条件中获取信息,并输出临界非线性屈曲载荷.利用哈密顿原理,考虑几何的非线性,建立了数学模型.通过将建模框架应用于各种边界条件情况以及三维功能梯度FG指标等物理参数对非线性力学行为的影响,仔细检验了建模框架的准确性.最后,利用广义微分求积法(GDQM)对PINNs结果进行了验证.研究结果表明,所提出的PINN框架能够较好地表征三维功能梯度FG多孔细长梁的非线性屈曲行为.此外,PINN预测梁的非线性屈曲行为的速度比数值方法快71倍.

摘要：In many circumstances,dissimilar metals have to be bonded together and the resulting joint interfaces must typically sustain mechanical and/or electrical forces without failure,which is not possible by fusion welding *** melting points of magnesium(Mg)and copper(Cu)have a significant difference(nearly 400℃)and this may lead to a large difference in the microstructure and joint performance of Mg-Cu ***,diffusion bonding can be used to join these alloys without much *** work analyses the effect of parameters on diffusion layer thickness,hardness and strength of magnesium-copper dissimilar *** experiments were conducted using three-factor,five-level,central composite rotatable design *** relationships were developed to predict diffusion layer thickness,hardness and strength using response surface *** is found that bonding temperature has predominant effect on bond *** fabricated at a bonding temperature of 450℃, bonding pressure of 12 MPa and bonding time of 30 min exhibited maximum shear strength and bonding strength of 66 and 81 MPa, respectively.

摘要：The design and fabrication processes of a novel scanner withminimized coupling motions for a high-speed atomic force microscope (AFM) were *** appropriate design modification was proposed through the analyses of the dynamic characteristics of existing linear motion stages using a dynamic analysis program,*** the scanning speed of each direction may differ,the linear motion stage for a high-speed scanner was designed to have different resonance frequencies for the modes,with one dominant displacement in the desired *** objective was achieved by using one-direction flexure mechanisms for each direction and mounting one stage for fast motion on the other stage for slow *** unsymmetrical configuration separated the frequencies of two vibration modes with one dominant displacement in each desired direction,and hence suppressed the coupling between motions in two directions.A pair of actuators was used for each axis to decrease the crosstalk between the two motions and give a sufficient force to actuate the slow motion stage,which carried the fast motion stage.A lossy material,such as grease,was inserted into the flexure hinge to suppress vibration problems that occurred when using an input triangular *** these design modifications and the vibration suppression method,a novel scanner with a scanning speed greater than 20 Hz is achieved.

摘要：Rotational atherectomy is an effective treatment for severe vascular calcification obstruction,and relies on high-speed grinding(typically 130,000–210,000 r/min)with miniature grinding tools to remove calcified tissue and restore blood ***,reports of intraoperative complications are common because of the grinding force,temperature,and debris directly acting on the body during the grinding process,which can easily cause damage to *** this study,three novel grinding tools were designed and fabricated and a series of experiments have been conducted to analyze the effects of tool geometry and parameters on grinding performance,that is,force,temperature,and specimen surface *** results show that these tools can effectively remove simulated calcified tissue and that they have two motions,rotation and revolution,in the *** higher rotational speeds,grinding force and temperature increase noticeably,while the amount of debris decreases *** addition,by observing the surface morphology of the specimens,we concluded that the material removal rate per unit time is influenced by both rotational speed and tool geometry,and that high rotational speed and a rough tool surface can improve the material removal rate efficiently.

摘要：In order to guarantee the overall production performance of the multiple departments in an air-condition production industry, multidisciplinary design optimization model for production system is established based on the multi-agent technology. Local operation models for departments of plan, marketing, sales, purchasing, as well as production and warehouse are formulated into individual agents, and their respective local objectives are collectively formulated into a multi-objective optimization problem. Considering the coupling effects among the correlated agents, the optimization process is carried out based on self-adaptive chaos immune optimization algorithm with mutative scale. The numerical results indicate that the proposed multi-agent optimization model truly reflects the actual situations of the air-condition production system. The proposed multi-agent based multidisciplinary design optimization method can help companies enhance their income ratio and profit by about 33% and 36%, respectively, and reduce the total cost by about 1.8%.