摘要：Malaria still threatens global health seriously *** the current discoveries of antimalarials are almost totally focused on single mode-of-action inhibitors,multi-targeting inhibitors are highly desired to overcome the increasingly serious drug ***,we performed a structure-based drug design on mitochondrial respiratory chain of Plasmodium falciparum and identified an extremely potent molecule,RYL-581,which binds to multiple protein binding sites of *** simultaneously(allosteric site of type Ⅱ NADH dehydrogenase,Q_(o) and Q_(i) sites of cytochrome bc_(1)).Antimalarials with such multiple targeting mechanism of action have never been reported ***-581 kills various drug-resistant strains in vitro and shows good solubility as well as in vivo *** structurebased strategy for designing RYL-581 from starting compound may be helpful for other medicinal chemistry projects in the future,especially for drug discovery on membrane-associated targets.

摘要：Structural colors,derived from existing natural creatures,have aroused widespread attention in the materials regulation for different ***,inspired by the color adjusting mechanism of hummingbird,we present a novel shape-memory structural color hydrogel film by introducing shape memory polymers(SMPs)into synthetic inverse opal scaffold *** excellent flexibility as well as the inverse opal structure of the hydrogel films imparts them with stable stretchability and brilliant structural *** from the transient structural anisotropy of copolymers,the hybrid films are possessed with shape-morphing behaviors *** on the shape transformations and color responsiveness performance,we have demonstrated diverse structural color actuators with complex shapes for different ***,as the photothermal responsive graphene quantum dots were integrated into the hydrogel,the hybrid films could also be endowed with the feature of light-controlled reversible deformation with synchronous structural color *** features demonstrate that the presented shape-memory structural color hydrogel film is valuable for soft robotics with multifunctions of sensing,communication and disguise.

摘要：Shape memory materials possess programmable complex and large deformations towards external stimuli,which are particularly essential for their potential *** the transformation of planar two-dimensional(2D)structures into complex 3D structures,the design of asymmetric or bilayer thin sheets is usually *** this paper,we propose a facile strategy to achieve these complex 3D structures that can be transformed to various pre-determined shapes sequentially by laser-triggered site-specific *** response of shape memory polycaprolactone(PCL)to laser is realized by physically dopingW18O49 nanowires into the cross-linked PCL diacrylate *** irradiated by 98 mW cm^(−2)laser,the pre-stretched PCL/W_(18)O_(49)film shows an out-of-plane bending deformation due to the temperature gradient and single-domain orientation on the thickness between the upper layer and lower *** bending rates and amplitudes of the film can be tailored by adjusting the parameters of irradiation time,the film thickness as well as the pre-stretch ***,the pre-stretched film can automatically bend in more intricate complex deformations by integration with kirigami cuts in ***,we demonstrate that by activating the dynamic transesterification reaction within the same film,it can also achieve the 2D-to-3D *** these decent features,this kind of novel PCL//W_(18)O_(49)film shows great potential in the field of biomedical devices or soft robotics.

摘要：肿瘤微环境中的血管生成是肿瘤细胞对放化疗不敏感的主要原因.在本项研究中,我们设计了一种微环境响应型的纳米颗粒,利用ZrMOF的分解产物抑制肿瘤细胞中的PI3K/AKT/mTOR/VEGF通路,从而克服A549R细胞对顺铂的耐药性.我们将顺铂包裹在Zr-MOF中,并在表面修饰BSA,形成了CDDP@Zr-MOF-BSA纳米复合体,该复合体在肿瘤微环境中有良好的响应性,有助于在肿瘤区域蓄积,展现出卓越的血管生成抑制能力,并能明显降低药物的外排.此外,CDDP@Zr-MOFBSA能显著抑制多药耐药相关蛋白1(MRP1)的表达,从而逆转A549R细胞的耐药性.总体而言,CDDP@Zr-MOF-BSA对A549R有细胞毒性,能抑制肿瘤微环境中的血管生成,最终有效提高顺铂耐药肿瘤的治疗效果.CDDP@Zr-MOF-BSA为放化疗治疗耐药肿瘤提供了一种多功能协同的方法.

摘要：Biocompatible and biodegradable ε-poly-L- lysine （EPL）/poly （ε-caprolactone） （PCL） copolymer was designed and synthesized. The amphiphilic EPL-PCL copolymer could easily self-assembled into monodispersed nanoparticles （NPs）, which showed a broad-spectrum antibacterial activity against Escherichia coli, Staphylococcus aureus and Bacillus subtilis. Interestingly, the antibacterial efficacy of the novel NPs is more potent than the cationic peptide EPL. To explore the underlying mechanism of the biodegradable cationic NPs, various possible antibacterial pathways have been validated. The NPs have been found that they can disrupt bacterial walls/ membranes and induce the increasing in reactive oxygen species and alkaline phosphatase levels. More importantly, the self-assembled NPs induced the changes in bacterial osmotic pressure, resulting in cell invagination to form holes and cause the leakage of cytoplasm. Taken together, our results suggest that the EPL-PCL NPs can be further developed to be a promising antimicrobial agent to treat infectious diseases as surfactants and emulsifiers to enhance drug encapsulation efficiency and antimicrobial activity.

摘要：过渡金属氧化物(TMOs)用作电极材料时,会在循环过程中产生严重的体积变化,并且其自身的导电率也较低,因此它的电化学性能较差.设计和开发独特的TMOs纳米结构并将其与导电碳基底相结合是改善其电化学性能的有效策略.本工作中,我们设计了一种C/Cu多孔微球,并通过原位合成在碳壁上垂直生长Co_(3)O_(4)纳米片.作为导电基底,C/Cu多孔微球提供了多尺度孔隙网络和大的电极/电解质接触界面,显著改善了电子和离子扩散动力学.原位合成的Co_(3)O_(4)纳米片牢牢地固定在碳壁上,从而提高了复合微球在长期循环中的结构稳定性.得益于独特的结构特征,用作锂离子电池负极材料的C/Cu@Co_(3)O_(4)复合多孔微球表现出优异的倍率性能、高充电比容量和出色的循环稳定性.

摘要：Conductive and adhesive hydrogels are promising materials for designing *** satisfy the high conductivity of bioelectronic devices,metal nanomaterials have been used to fabricate composite ***,the fabrication of a conductive-nanomaterial-incorporated hydrogel with high performance is a great challenge because of the easy aggregation nature of conductive nanomaterials making processing ***,we report a kind of adhesive aero-hydrogel hybrid conductor(AAHC)with stretchable,adhesive and anti-bacteria properties by in situ formation of a hydrogel network in the aerogel-silver nanowires(AgNWs)*** AgNWs with good conductivity are wellintegrated on the inner-surface of shape-memory chitosan aerogel,which created a conductive framework to allow hydrogel *** by the aerogel-silver makes the hybrid hydrogel tough and *** groups from the hydrogel allow strong adhesion to wet tissues through molecular *** inherent bacteria-killing ability of silver ions endows the conductive hydrogel with excellent anti-bacteria *** proposed facile strategy of aerogel-assisted assembly of metal nanomaterials with hydrogel opens a new route to incorporate functional nanoscale building blocks into hydrogels.

摘要：In this paper, we report the design and moleculardocking study of analogues of antimycin A3 as inhibitors of anti-apoptotic Bcl-2 of breast cancer. Twenty designed compounds and the original antimycin A3 were docked based on their interaction with breast tumor receptor binding target Bcl-2. The docking resulted in the five top-ranked compounds, namely, compounds 11, 14, 15, 16, and 20, which have a lower G binding energy, better affinity and stronger hydrogen bonding interactions to the active site of Bcl-2 than antimycin A3. Among those five top-ranked compounds, analogue compounds 11 and 14, which have an 18-membered tetralactone core and 18-membered tetraol core, respectively, exhibited the strongest hydrogen bond interaction, formed high stability conformation, and demonstrated the greatest inhibitory activity on the catalytic site of Bcl-2.

摘要：目的本研究旨在确定护士对家属在场时实施复苏的自信心与实践之间的关系,并描述护士对相关情形的偏好。方法采用横断面调查方法,研究对象来自肯尼亚西阿亚县转诊医院内外科不同单元。采用匿名自填问卷进行调查,主要测量工具为Twibel等设计的家属在场自信量表(Family Presence Self-confi-dence Scale)。采用χ^(2)检验和二元回归分析进行统计学分析。结果护士对家属在场时实施复苏操作的自信心与实践存在关联(χ^(2)=8.060,P=0.01)。非常自信的护士在临床实践中实施家属在场情况下复苏操作的可能性是有点自信的护士的4.9倍(OR=4.94,95%CI 1.07~22.71)。结论护士对实施家属在场复苏操作的自信心差异较大。为成功实施家属在场复苏实践,护士还需通过更多专门培训和实践获得更高水平的自信心。

摘要：介绍了一个国外大学化学专业本科生有机化学实验'相转移催化剂的应用',介绍了实验设计与流程,分析了实验结果,并讨论其相关的问题。该实验涉及到整套的现代有机合成流程,如薄层层析色谱(TLC)技术与硅胶柱色谱分离技术,并通过半微量反应的设计,减少对环境有害物质的使用,体现了'绿色化学'的设计理念,值得国内本科生有机化学实验借鉴与学习。