摘要：In previous studies, N,O-carboxymethyl chitosan has been shown to decrease the incidence and intensity of abdominal adhesions. In the present study, adhesions were induced in 220 rabbits using a double uterine horn model. Rabbits were randomized to receive an operation only or an operation+medical chitosan intraperitoneally. Twenty-two rabbits from each group were euthanized at one of five different times(Day 3, 7, 14, 28, or 42), and adhesion formation was given gross and histopathological scores. Reductions were observed in adhesion extent(P=0.0337) and tenacity(P=0.0271) as well as inflammation(P<0.0001) on Day 3 when medical chitosan was applied. Prior to Day 14, fibrosis was less obvious in the medical chitosan group(P<0.0005). The tenacity scores were significantly lower in the medical chitosan group following Day 14(P<0.05), while the type scores were lower in the medical chitosan group following Day 28(P<0.03). Thus, medical chitosan decreased both the gross and the histopathological scores of the induced adhesions.

摘要：目的:阐明二氧化碳(CO2)激光眼睑皮肤再铺平(resurfacing)后机体内的愈合情况。设计:要求做上眼睑成形术的患者,同意在不同间隔时间切除一部分先前经受过CO2激光皮肤再铺平的上睑皮肤。睑成形术后,其皮肤标本由2位互不了解的病理学家进行组织病理学分析。患者:8例为FitzpatrickⅠ型和Ⅱ型皮肤的患者。手术:在计划上眼睑成形术前1、2、4或12周进行上睑CO2激光再铺平。主要结果测量:表皮:厚度,极性,轮廓和结构。真皮:修复区厚度,血管和炎症类型,胶原沉积,和弹力纤维变化。结果:7-10天内表皮再生。至3个月时,表皮显示出变平的表皮突伴有极性,角化细胞和黑素细胞的恢复。3个月的真皮显示有纤维修复区(500-700μm)、新的弹力纤维和扩张的毛细血管。结论:眼睑皮肤的愈合类似于其他部位皮肤经CO2激光再铺平后的愈合情况。这种皮肤的愈合与以前报道的使用化学脱皮术的皮肤愈合类似。组织学的改变可以解释临床所见的皮肤变光滑和皱纹减少。