摘要：The development of natural biomaterials applied for hard tissue repair and regeneration is of great importance,especially in societies with a large elderly ***-assembled peptide hydrogels are a new generation of biomaterials that provide excellent biocompatibility,tunable mechanical stability,injectability,trigger capability,lack of immunogenic reactions,and the ability to load cells and active pharmaceutical agents for tissue ***-based hydrogels are ideal templates for the deposition of hydroxyapatite crystals,which can mimic the extracellular ***,peptide-based hydrogels enhance hard tissue repair and regeneration compared to conventional *** review presents three major self-assembled peptide hydrogels with potential application for bone and dental tissue regeneration,including ionic self-complementary peptides,amphiphilic(surfactant-like)peptides,and triple-helix(collagen-like)*** attention is given to the main bioactive peptides,the role and importance of self-assembled peptide hydrogels,and a brief overview on molecular simulation of self-assembled peptide hydrogels applied for bone and dental tissue engineering and regeneration.