摘要：The three-dimensional (3D)bioprinting technology has progressed tremendously over the past *** controlling the size, shape,and architecture of the bioprinted constructs,3D bioprinting allows for the fabrication of tissue/organ-like constructs with strong structural-functional similarity with their in vivo counterparts at high *** bioink,a blend of biomaterials and living cells possessing both high biocompatibility and printability,is a critical component of *** particular, gelatin methacryloyl (GelMA)has shown its potential as a viable bioink material due to its suitable biocompatibility and readily tunable physicochemical *** GelMA-based bioinks and relevant bioprinting strategies for GelMA bioprinting are briefly reviewed.

摘要：Designing an excellent original topology not only improves the accuracy of routing, but also improves the restoring rate of failure. In this paper, we propose a new heuristic topology generation algorithm—GA-PODCC (Genetic Algorithm based on the Pareoto Optimality of Delay, Configuration and Consumption), which utilizes a genetic algorithm to optimize the link delay and resource configuration/consumption. The novelty lies in designing the two stages of genetic operation: The first stage is to pick the best population by means of the crossover, mutation, and selection operation;The second stage is to select an excellent individual from the best population. The simulation results show that, using the same number of nodes, GA-PODCC algorithm improves the balance of all the three optimization objectives, maintaining a low level of distortion in topology aggregation.

摘要：The thermal conduction of suspended few-layer hexagonal boron nitride （h-BN） sheets was experimentally investigated using a noncontact micro-Raman spectroscopy method. The first-order temperature coefficients for monolayer （1L）, bilayer （2L） and nine-layer （9L） h-BN sheets were measured to be -（3.41 ± 0.12）× 10-2, -（3.15 ± 0.14） × 10-2 and -（3.78 ±0.16）× 10-2 cm-1.K-1, respectively. The room-temperature thermal conductivity of few-layer h-BN sheets was found to be in the range from 227 to 280 W.m-1-K-1, which is comparable to that of bulk h-BN, indicating their potential use as important components to solve heat dissipation problems in thermal management configurations.

摘要：Patterning ultrathin MoS2 layers with regular edges or controllable shapes is appealing since the properties of MoS2 sheets are sensitive to the edge structures. In this work, we have introduced a simple, effective and well-controlled technique to etch layered MoS2 sheets with well-oriented equilateral triangular pits by simply heating the samples in air. The anisotropic oxidative etching is greatly affected by the surrounding temperature and the number of MoS2 layers, whereby the pit sizes increase with the increase of surrounding temperature and the number of MoS2 layers. First-principles computations have been performed to explain the formation mechanism of the triangular pits. This technique offers an alternative avenue to engineering the structure of MoS2 sheets.

摘要：本文提出了全面学习和相量粒子群相结合的方法用于解决限定固有频率约束下的空间结构优化问题.通过将相量理论和全面学习策略相结合以提高粒子群算法的效率.在优化的过程中,一个所谓的相角采用了周期正弦和余弦函数给定义速度的关键参数建模使得速度可以从所有粒子前一步的最佳位置中选取.这个方法不但实现了粒子们可以快速学习并且在少量的计算中进行了在作用力和固有频率约束下结构杆件的安全性评估和优化尺寸分布.提出的优化设计方法成功解决了一些工程应用结构的基准设计问题,这证明了本文方法相对于最新元启发方法的准确性和稳定性.

摘要：This vertically self‐pillared(VSP)structure extends the application range of traditional porous materials with facile mass/ion transport and enhanced reaction ***,we prepare a single crystal metal‐organic framework(MOF),employing the ZIF‐67 structure as a proof of concept,which is constructed by vertically self‐pillared nanosheets(VSP‐MOF).We further converted VSP‐MOF into VSP‐cobalt sulfide(VSP‐CoS2)through a sulfidation *** plays an important role in almost all battery technologies;for metallic batteries,lithium anodes exhibit a high theoretical specific capacity,low density,and low redox ***,during the half‐cell reaction(Li++e=Li),uncontrolled dendritic Li penetrates the separator and solid electrolyte interphase *** employed as a composite scaffold for lithium metal deposition,there are many advantage to using this framework:1)the VSP‐CoS2 substrate provides a high specific surface area to dissipate the ion flux and mass transfer and acts as a pre‐catalyst,2)the catalytic Co center favors the charge transfer process and preferentially binds the Li+with the enhanced electrical fields,and 3)the VSP structure guides the metallic propagation along the nanosheet 2D orientation without the protrusive *** these features enable the VSP structure in metallic batteries with encouraging performances.

摘要：Multicellular microtissues of primary human hepatocytes(PHHs)co-cultured with other supporting cell types are a promis-ing model for drug screening and toxicological ***,these liver microtissues(LMs)rapidly lose their functions during ex vivo ***,in order to mimic the cellular and structural hepatic microenvironment,we co-cultured PHHs with human mesenchymal stromal cells(MSCs)and human umbilical vein endothelial cells(HUVECs)in the presence of cell-sized microparticles(MPs)derived from liver extracellular matrix(LEMPs).The microwell culture platform enabled biofabrication of size-controlled multicellular microtissues(PHH:HUVEC:MSC=3:2:1)with efficient LEMP incorporation(about 70%at a 2:1 ratio of cells:MP).The biofabricated liver microtissues(BLMs)were cultured ex vivo for 14 days and compared to the cell-only LM in terms of gene and protein expression,functional activity,cytochrome P450(CYP450)enzyme inducibility,and drug *** results supported superior hepatic-related gene expression,functional activity,and polarity for PHH in BLM compared to ***450 enzyme inducibility and dose-responsive sensitivity to toxic drugs were significantly higher in the BLM *** conclusion,microtissue engineering by incorporation of tissue-specific microparticles within a multicellular microtissue can offer some advantages for drug discovery studies and cell transplantation *** the near future,this approach could generate a scalable platform of several functional biofabricated microtissues representing different organs.

摘要：Ankylosing spondylitis(AS) is a chronic inflammatory disease that affects 1% of the general population. As one of the most severe types of spondyloarthropathy, AS affects the spinal vertebrae and sacroiliac joints, causing debilitating pain and loss of mobility. The goal of this review is to provide an overview of AS, from the pathophysiological changes that occur as the disease progresses, to genetic factors that are involved with its onset. Considering the high prevalence in the population, and the debilitating life changes that occur as a result of the disease, a strong emphasis is placed on the diagnostic imaging methods that are used to detect this condition, as well as several treatment methods that could improve the health of individuals diagnosed with AS.

摘要：Global demand for food and bioenergy production has increased rapidly,while the area of arable land has been declining for decades due to damage caused by erosion,pollution,sea level rise,urban development,soil salinization,and water scarcity driven by global climate *** order to overcome this conflict,there is an urgent need to adapt conventional agriculture to water-limited and hotter conditions with plant crop systems that display higher water-use efficiency(WUE).Crassulacean acid metabolism(CAM)species have substantially higher WUE than species performing C3 or C4 *** plants are derived from C3 photosynthesis ***,it is extremely unlikely that the C3 or C4 crop plants would evolve rapidly into CAM photosynthesis without human ***,there is growing interest in improving WUE through transferring CAM into C3 ***,engineering a major metabolic plant pathway,like CAM,is challenging and requires a comprehensive deep understanding of the enzymatic reactions and regulatory networks in both C3 and CAM photosynthesis,as well as overcoming physiometabolic limitations such as diurnal stomatal *** advances in CAM evolutionary genomics research,genome editing,and synthetic biology have increased the likelihood of successful acceleration of C3-to-CAM ***,we first summarize the systems biology-level understanding of the molecular processes in the CAM ***,we review the principles of CAM engineering in an evolutionary ***,we discuss the technical approaches to accelerate the C3-to-CAM transition in plants using synthetic biology toolboxes.

摘要：Recent advances in non-radiative wireless power transfer(WPT)technique essentially relying on magnetic resonance and near-field coupling have successfully enabled a wide range of ***,WPT systems based on double resonators are severely limited to short-or mid-range distance,due to the deteriorating efficiency and power with long transfer *** systems based on multi-relay resonators can overcome this problem,which,however,suffer from sensitivity to perturbations and fabrication ***,we experimentally demonstrate a concept of topological wireless power transfer(TWPT),where energy is transferred efficiently via the near-field coupling between two topological edge states localized at the ends of a one-dimensional radiowave topological *** a TWPT system can be modelled as a parity-time-symmetric Su-Schrieffer-Heeger(SSH)chain with complex boundary ***,the coil configurations are judiciously designed,which significantly suppress the unwanted cross-couplings between nonadjacent coils that could break the chiral symmetry of the SSH *** tuning the inter-and intra-cell coupling strengths,we theoretically and experimentally demonstrate high energy transfer efficiency near the exceptional point of the topological edge states,even in the presence of *** combination of topological metamaterials,non-Hermitian physics,and WPT techniques could promise a variety of robust,efficient WPT applications over long distances in electronics,transportation,and industry.