摘要：Cancer is the most common cause of human mortality and has created an unbridgeable health gap due to its unrestrained aberrant proliferation,rapid growth,metastasis,and high *** two-dimensional cell culture and animal models for tumor diagnostic and therapeutic studies have extremely low clinical translation rates due to their intrinsic *** tumor models are therefore required for cancer *** human three-dimensional(3D)cancer models stand out for their ability to better replicate the spatial organization,cellular resources,and microenvironmental features(e.g.,hypoxia,necrosis,and delayed proliferation)of actual human ***,the fabrication of these models can be achieved by an emerging technology known as 3D bioprinting,which allows for the fabrication of living structures by precisely regulating the spatial distribution of cells,biomolecules,and matrix *** aim of this paper is to review the current technologies and bioinks associated with 3D bioprinted cancer models for glioma,breast,liver,intestinal,cervical,ovarian,and neuroblastoma,as well as,advances in the applications of 3D bioprinted-based tumor models in the fields of tumor microenvironment,tumor vascularization,tumor stem cells,tumor resistance and therapeutic drug screening,tumorimmunotherapy,and precision medicine.

摘要：This paper aims to explore the ability of genetic programming(GP)to achieve the intelligent prediction of tunnelling-induced building deformation considering the multifactor impact.A total of 1099 groups of data obtained from 22 geotechnical centrifuge tests are used for model development and analysis using *** volume loss,building eccentricity,soil density,building transverse width,building shear stiffness and building load are selected as the inputs,and shear distortion is selected as the *** suggest that the proposed intelligent prediction model is capable of providing a reasonable and accurate prediction of framed building shear distortion due to tunnel construction with realistic conditions,highlighting the important roles of shear stiffness of framed buildings and the pressure beneath the foundation on structural *** has been proven that the proposed model is efficient and feasible to analyze relevant engineering problems by parametric analysis and comparative *** findings demonstrate the great potential of GP approaches in predicting building distortion caused by *** proposed equation can be used for the quick and intelligent prediction of tunnelling induced building deformation,providing valuable guidance for the practical design and risk assessment of urban tunnel construction projects.

摘要：The cultural customs of compiling genealogy for 5,000 years are an integral part of the Chinese *** the new socialist era,compiling new genealogy is a continuation and development of old genealogy,a cultural phenomenon adapting to social and public *** paper examines how Chinese genealogies transformed,and then explores how new genealogies have the new cultural function of serving the socialist *** paper concludes with comments on how new compilations play a positive role in the construction of a harmonious society.

摘要：In this review, we retrospect our progress in biological active naphthalimide and analogues as antitumor agents in the past 20 years. On one hand, various derivations in naphthalimide pharmacophores were developed to enhance their DNA binding affinity and antitumor property thereby. Heterocyclic fused naphthalimides, bis-naphthalimides, non-fused substituted naphthalimides and the carboxamide derivatives were synthesized. For example, thio-heterocyclic fused-naphthalimides were designed and evaluated in comparison with their oxo-heterocyclic fused analogues. Extended or created heterocyclebased skeleton were also developed as antitumor agents. On the other hand, we broaden the design strategy of naphthalimide antitumor agents besides DNA intercalation and topo II poison. We have introduced more drug design methods, such as prodrugs, multitarget drugs, computer-aided drug design,photodynamic therapy. For example, we have got naphthalimide derivatives which inhibited topo II and induced LMP by introducing long alkyl chain and polyamines. Several representative compounds were clarified of their antitumor mechanism of action. In all, our research improves the structure diversity of naphthalimide antitumor agents and distinct variances of antitumor targets and mechanism of action.

摘要：At present, from the aspect of promoting consumers＇ pro-social consumption behaviors, the public service ads has a clearly insufficient persuasive problem. In order to make a theoretical explanation and provide suggestions for this phenomenon, this article compares the effect of different orientations of public service ads＇ appeals on the tendency of individual＇ s pro-social consumption behaviors experiment. The experimental results prove that comparatively speaking, altruism orientation of public service ads＇ appeals can make the individual to produce higher levels of pro-social consumption behaviors. Based on the above research results, the author respectively puts forward some advices about public service ads for the management of profit and non-profit organizations.

摘要：Glycerol is one of the most important biomass-based platform molecules,massively produced as a by-product in the biodiesel *** high purification cost from the crude glycerol raw material limits its application and demands new strategies for *** to the conventional thermocatalytic strategies,the electrocatalytic strategies can not only enable the selective conversion at mild conditions but also pair up the cathodic reactions for the co-production with higher *** this review,we summarize the recent advances of catalyst designs and mechanistic understandings for the electrocatalytic glycerol oxidation(GOR),and aim to provide an overview of the GOR process and the intrinsic structural-activity correlation for inspiring future work in this *** review is dissected into three *** will first introduce the recent efforts of designing more efficient and selective catalysts for GOR,especially toward the production of value-added ***,we will summarize the current understandings about the reaction network based on the ex-situ and in-situ spectroscopic studies as well as the theoretical ***,we will select some representative examples of creating real electrochemical devices for the valorization of *** summarizing these previous efforts,we will provide our vision of future directions in the field of GOR toward real applications.

摘要：The humanistic quality is one of the most important qualities for students to acquire in humanistic ***,the limited class time for tightly scheduled teaching tasks fails to guarantee a satisfying result for humanistic *** this paper,three strategies are proposed as the way out of this *** first,is to equip the College English teachers with rich professional and humanistic *** second is to change the traditional College English Teaching aim which is not suitable as a guide for current *** the last is to require all the English teachers to explore and clarify the humanistic connotation in the texts which helps shape students’view of the world and value of the life.

摘要：生物质是世界上广泛存在的可再生资源,可以转化成高价值燃料和化学品.基于可再生能源产生的电力,将生物质衍生的5-羟甲基糠醛(HMF)电催化转化为2,5-呋喃二甲醇(BHMF)具有重要的研究意义和应用价值.HMF在电转化过程中容易发生二聚反应,从而导致BHMF的选择性较低,产物分离难度大.因此,探索获得高选择性BHMF的高效催化体系极为重要.在此,本文报道了Rh掺杂的Cu纳米线催化剂,其在HMF电还原为BHMF反应中表现出较高的转化率,且有效抑制了二聚反应的发生.动力学实验和原位光谱研究表明,Rh的引入可以有效促进水解离形成活性氢物种,促进5-羟甲基糠醛电催化加氢并抑制其二聚.此催化剂设计策略可以拓展到其他生物质衍生分子的电催化转化过程中.

摘要：具有电化学变色功能的柔性电池在智能电子领域显示出巨大的应用潜力.然而,具有可视化电量预警功能的镍锌电池目前尚未见报道.在此,我们设计了一种用于柔性镍锌电池的电致变色镍钴氢氧化物/镍/氧化铟锡(NiCo BH/Ni/ITO)柔性电极.通过优化Ni层厚度,电极在电流密度为0.1 mA cm^(-2)时,着色效率为59.89 cm^(2)C^(-1),容量为7.15μA h cm^(-2).相应组装的电致变色镍锌电池功率密度为160μW cm^(-2)时,能量密度为12.69μW h cm^(-2),优于部分文献报道的透明柔性超级电容器和电致变色电池.值得注意的是,组装的镍锌电池在充放电过程中显示出可逆的颜色变化,提供了一种可视化监测电池剩余电量的新功能.

摘要：Au sites supported on Ti-containing materials(Au/Ti-containing catalyst)are currently considered as a promising catalyst for the propylene epoxidation owing to the synergistic effect that hydrogen peroxide species formed on Au sites diffuses to the Ti sites to form the Ti-hydroperoxo intermedi-ates and contributes to the formation of propylene oxide(PO).In principle,thermal treatment will significantly affect the chemical and physical structures of Ti-containing ***,the synergy between tailored Ti sites with different surface properties and Au sites is highly expected to enhance the catalytic performance for the ***,we systematically studied the intrinsic effects of different microenvironments around Ti sites on the PO adsorption/desorption and conversion,and then effectively improved the catalytic performance by tailoring the number of surface hydroxyl *** Ti^(Ⅵ) material with fewer hydroxyls stimulates a remarkable enhancement in PO selectivity and H_(2) efficiency compared to the Ti^(Ⅵ) material that possessed more hydroxyls,offering a 7-fold and 4-fold increase,*** expected,the Ti^(Ⅵ+Ⅳ) and Ti^(Ⅳ) materials also exhibit a similar phenomenon to the Ti^(Ⅵ) materials through the same thermal treatment,which strongly supports that the Ti sites microenvironment is an important factor in suppressing PO con-version and enhancing catalytic *** insights could provide guidance for the rational preparation and optimization of Ti-containing materials synergizing with Au catalysts for propylene epoxidation.