摘要：For complex industrial processes with multiple operational conditions, it is important to develop effective monitoring algorithms to ensure the safety of production processes. This paper proposes a novel monitoring strategy based on fuzzy C-means. The high dimensional historical data are transferred to a low dimensional subspace spanned by locality preserving projection. Then the scores in the novel subspace are classified into several overlapped clusters, each representing an operational mode. The distance statistics of each cluster are integrated though the membership values into a novel BID (Bayesian inference distance) monitoring index. The efficiency and effectiveness of the proposed method are validated though the Tennessee eastman benchmark process.

摘要：在相同机器上安排工作是经常在各种各样的生产系统遇到的一种状况。在这份报纸，一新联合了短暂地混乱的神经网络(CTCNN ) 被提出解决相同平行机器安排。这个问题的一个混合整数编程模型被介绍一个排列矩阵表达式转变成 CTCNN 计算体系结构。新计算精力功能被建议除所有限制以外表示目的。特别地，在精力功能在惩罚术语之中存在的折衷问题被使用变化时间的惩罚参数克服。最后，结果与 100 个随机的起始的条件在 3 个不同规模问题上测试了证明网络收敛并且能在合理时间解决这些问题。

摘要：Interests in intracellular peptide delivery have continued to grow,significantly fueled by the importance of peptides and their mimetics in modern cell biology and pharmaceutical ***,efficient intracellular delivery of membrane-impermeable peptides of different polarities remains a challenging *** this study,we develop a general and robust strategy for intracellular peptide delivery by using a boronic acid-rich *** designed material is capable of transporting peptides with different polarities and charge properties into the cytosol of various cell lines without inducing additional *** transduction efficacy and proteolytic stability of cargo peptides delivered by the boronic acid-rich dendrimer are much superior to peptides conjugated with cell penetrant peptides such as *** addition,the bioactivities of pro-apoptotic peptides are maintained after intracellular *** study provides a versatile and robust platform for the intracellular delivery of membrane-impermeable peptides.

摘要：The creation of Cu^(0)/Cu^(+)interface over Cubased catalysts is known to facilitate the production of multicarbon(C_(2+))products during CO_(2)reduction reaction(CO_(2)RR).However,the Cu^(+)moieties exhibit high susceptibility towards reduction into Cu^(0)at a high current ***,a comprehensive understanding and rational shaping strategy for the construction and stabilization of Cu^(0)/Cu^(+)interface in Cu-based catalysts is ***,we proposed a controllable“nanoparticle assembly”strategy to obtain hollow spherical assemblies(HSA)composed of numerous Cu_(2)O nanoparticles(HSA-Cu_(2)O).The HSA-Cu_(2)O catalysts significantly enhance the selectivity of C_(2+)products,resulting in an impressive overall Faraday efficiency(FE)of 79.2%±0.7%at a partial current density of 317.1 mA cm−*** HSA-Cu_(2)O catalysts undergo in-situ electrochemically reconstruction during CO_(2)RR,achieving Cu^(0)/Cu^(+)interfacial sites with a high *** Auger electron spectra,in-situ Raman,and morphological evolution studies have confirmed that the combination of the Cu^(0)/Cu^(+)interface and hollow sphere architecture facilitated the concentration of*CO intermediates,thereby promoting C–C dimerization to boost C_(2+)selectivity in CO_(2)RR.

摘要：The relationship between the differentiated production and the differentiated film market system is paid more attention *** paper clarifies how to explore“extended screening”and“differentiated screening”,how to give art films a place to survive and thrive,and how to give audiences a variety of *** effective suggestions are given from three *** differentiated low and mid-budget films are tower base and *** is also necessary to comprehensively promote the development of a differentiated film market system in order to make differentiated,localized and genre-based productions that are competitive in the market.

摘要：The formal modelling and verification method has become an effective way of improving the reliability and correctness of complex,safety-critical embedded *** are widely used to formally model embedded applications,but they do not realise the reasonable separation of system concerns,which would result in code scattering and ***-Oriented Software Development(AOSD)technology could separate crosscutting concerns from core concerns and identify potential problems in the early phase of the software development life ***,the paper proposes aspect-oriented timed statecharts(extended timed statecharts with AOSD)to separately model base functional requirements and other requirements(e.g.,scheduling,error handling),thereby improving the modularity and development efficiency of embedded ***,the dynamic behaviours of embedded systems are simulated and analysed to determine whether the model satisfies certain properties(e.g.,liveness,safety)described by computation tree logic ***,a given case demonstrates some desired properties processed with respect to the aspect-oriented timed statecharts model.

摘要：Developing novel electrode materials for li-thium-ion batteries （LIBs） with rapid charge/discharge cap- ability and high cycling stability remains a big challenge to date. Herein, we demonstrate the design and synthesis of ul- trathin MoS2 nanosheets in-situ grown on sponge-like carbon nanospheres by a simple diffusion-controiled process. The unique sponge-like carbon nanosphere core can be used as ＂reservoir＂ of electrolyte by adsorbing to shorten the ion- diffusion path, and meanwhile as ＂elastomer＂ to alleviate the structural change of the MoS2 nanosheets during the charge/ discharge processes. Furthermore, the vertical ultrathin MoS2 nanosheets with broadened interlayer space greatly enrich the electrochemical active sites. Consequently, the as-obtained MoS2/C nanospheres exhibit increased specific capacities at various rates with superior cycling stability compared to the MoS2/C floccules. It is reckoned that the present concept can be extended to other electrode materials for achieving high- rate and stable LIBs.

摘要：Future climate change is usually projected by coupled earth system models under specific emission sce- narios designed by integrated assessment models （IAMs）, and this offline approach means there is no interaction between the coupled earth system models and the IAMs. This paper introduces a new method to design possible future emission scenarios and corresponding climate change, in which a simple economic and climate damage component is added to the coupled earth system model of Beijing Normal university （BNU-ESM）. With the growth of population and technological expertise and the declining emission-to-output ratio described in the Dynamic Inte- grated Climate-Economy model, the projected carbon emission is 13.7 Gt C, resulting in a 2.4℃ warming by the end of the twenty-first century （2080-2099） compared with 1980-1999. This paper also suggests the importance of the land and ocean carbon cycle in determining the CO2 con- centration in the atmosphere. It is hoped that in the near future the next generation of coupled earth system models that include both the natural system and the social dimension will be developed.

摘要：A series of novel 5-（trifluoromethyl）-1H-pyrazole-4-carboxamide derivatives（6a–6n, 7a, 7b, and 8a-8f）were synthesised by placing the amide bond at the 4-position of the pyrazole ring. These derivatives differed from the structure of chlorantraniliprole analogues with the amide bond at the 5-position of the pyrazole ring. Preliminary bioassay results revealed that a few title compounds exhibited good insecticidal activities against lepidopteran pests, such as Plutella xylostella, Mythimna separate, Heliothis armigera, and Ostrinia nubilalis. Some title compounds also elicited broad-spectrum insecticidal activities against dipterous insects including Culex pipiens pallens after altering the amide position. Similar to pyrazole-5-carboxamide analogues, compounds 6b and 6e showed 100% insecticidal activity against P. xylostella, C. pipiens pallens, and M. separate at concentrations of 200, 2, and 200 mg/m L, *** finding suggested that 5-（trifluoromethyl）-1H-pyrazole-4-carboxamide derivatives are potential alternative insecticides for management of agriculture pests.

摘要：Resistance to malaria parasites has quickly developed to almost all used antimalarial drugs. Cysteine protease falcipain-2(FP-2) and Plasmodium falciparum dihydrofolate reductase(PfDHFR) have crucial roles, which are absolutely necessary, in the parasite life cycle. In this study, based on the uniform pharmacophores of reported PfDHFR inhibitors and the first-generation dual inhibitors against FP-2 and PfDHFR, we identified a novel series of dual inhibitors through fragments assembly. Lead optimization led to the identification of 14, which showed potent inhibition against FP-2 and PfDHFR enzyme(IC_(50)= 6.8 + 1.8 mmol/L and IC_(50)= 8.8 + 0.3 mmol/L) and P. falciparum 3D7 strain(IC50= 2.9mmol/L).Additionally, 14 exhibited more potent inhibition to the proliferation of chloroquine-resistant *** Dd2 strain(IC_(50)= 1.1 mmol/L) than pyrimethamine(IC_(50)>10 mmol/L), and 14 displayed micromolar inhibitory activities against two clinical isolated strains Fab9(IC_(50)= 2.6 mmol/L) and GB4(IC_(50)= 1.0 mmol/L). Collectively, these data demonstrated that 14 might be a good lead compound for the treatment of malaria.