摘要：Recently,the First Youth Forum of Bio-design&Manufac-turing(BDM)was held in Hangzhou on July 3,***-emician Huayong Yang,Editor-in-Chief of BDM,acted as the Chairman and this conference was jointly sponsored by the School of Mechanical engineering,Zhejiang Univer-sity,as well as the State Key laboratory of fluid Power and Mechatronic Systems.A total of 11 prestigious pro-fessors and researchers from all over the world presented at the conference either online or offline,while more than 150 researchers and students from different universities and research institutes attended and heatedly discussed their research in the fields of bio-design and manufacturing from various perspectives.

摘要：Dilemmas of current drug screening Recently,multiple technological advancements have been involved in the process of drug research and *** addition,the spending on the relevant projects has doubled in the last 20 years,cumulatively increasing 28%from 2014 to ***,these improvements have not led directly to an obvious increase in feasible drug candidates that successfully passed the clinical *** to the increased spending and stagnant clinical success rate of 10–20%,the efficiency of this project drastically decreased from around 40 drugs per billion in 1950 to 0.6 drugs in 2012.

摘要：The beam transport design of a novel proton dielectric wall accelerator is introduced in this paper. The protons will be accelerated from 40 keV to nearly 1 MeV under an accelerating gradient that is as high as 20 MV/m. A consideration of the beam line as well as the transport simulation is presented. The influences of the injection timing jitter and the accelerating pulse timing jitter are also discussed.

摘要：Vectored non-covalent interactions—mainly hydrogen bonding and aromatic interactions—extensively contribute to(bio)-organic self-assembling processes and significantly impact the physicochemical properties of the associated ***,vectored non-covalent interaction-driven assembly occursmainly along one-dimensional(1D)or three-dimensional(3D)directions,and a two-dimensional(2D)orientation,especially that of multilayered,graphene-like assembly,has been reported *** this present research,by introducing amino,hydroxyl,and phenyl moieties to the triazine skeleton,supramolecular layered assembly is achieved by vectored non-covalent *** planar hydrogen bonding network results in high stability,with a thermal sustainability of up to about 330°C and a Young’s modulus of up to about 40 *** introducing wrinkles by biased hydrogen bonding or aromatic interactions to disturb the planar organization,the stability ***,the intertwined aromatic interactions prompt a red edge excitation shift effect inside the assemblies,inducing broad-spectrum fluorescence covering nearly the entire visible light region(400–650 nm).We show that bionic,superhydrophobic,pillar-like arrays with contact angles of up to about 170°can be engineered by aromatic interactions using a physical vapor deposition approach,which cannot be realized through hydrogen *** findings show the feasibility of 2D assembly with engineerable properties by modulating vectored non-covalent interactions.

摘要：Aerodynamic performance of low-Reynolds-number high-lift airfoil makes a great impact on designing a high-efficiency propeller for low-dynamic vehicles in stratosphere. At high altitude,low-Reynolds-number airfoils are supposed to have high lift-drag ratio or high endurance factor at cruising attack angle along with good stall characteristics. To design such a high-performance low-Reynolds-number high-lift airfoil,the paper established a hierarchical multi-objective optimization platform by combing direct search optimization algorithm EXTREM and airfoil flow field solver XFOIL to automatically and quickly calculate aerodynamic performance function of airfoil by computer. It provides an effective solution to multi-point design problem of low-speed low-Reynolds-number airfoil. It can be seen from the results of three typical optimization examples,the new airfoil E387_OPT2,FX63-137_OPT2 and S1223_OPT2 based on hot low-Reynolds-number high-lift airfoils (Eppler 387 airfoil,Wortmann FX63-137 airfoil and S1223 airfoil) can meet the optimization design requirements and have very good aerodynamic characteristics in both design state and non-design state. Thus,the applicability and effectiveness of hierarchical multi-objective optimization platform are verified.

摘要：The advancement in the micro-/nanofabrication techniques has greatly facilitated the development of micromotors.A variety of micromotors have been invented with powerful functions,which have attracted a broad range of interests from chemistry, physics,mechanics,biology and *** this paper,we reviewed recent progress in micromotors and highlighted representative *** mechanisms of micromotors by internal and external energy sources were *** described general fabrication strategies of the popular micromotors (wire,tubular,helical and Janus)including bottom-up and top-down *** the application section,we primarily focused on the biological applications,such as biological cargo delivery, biosensing and *** last,we discussed the current challenges and provided future prospects.

摘要：研究目的:提出一种采样设备,可同时满足浅海和深海热液的取样要求。创新要点:提出一种电控热液气密采样器,具有灵活的工作模式,便于潜水员和深潜器机械手操作,满足浅海和深海不同使用场合。研究方法:在传统热液采样器的基础上集成了温度实时测量与显示系统,设计了适用于浅海和深海的温度显示和信号触发腔(见图5、6),可方便潜水员和深潜器机械手操作。使用结构紧凑的电控触发器来控制采样,而且具有多种控制模式,因而使采样器的使用更加灵活。重要结论:采样器在浅海热液区进行了成功海试,验证了温度实时测量与显示系统能确保采样器获取高纯度的热液样品。

摘要：Introduction Why 3D cell culture urgently needed?Tissue engineering has extremely influenced the development process of basic biological studies and biomedical *** quite a long time,the vast majority of these researches have been relying on the experimental results of conventional two-dimensional(2D)cell culture in flask,petri dish or well ***,these 2D culture results could be very different with or even totally opposite to the actual situations in vivo where cells grow inside a 3D extracellular matrix(ECM).Therefore,3D cell culture has been playing a more and more significant role because of its higher accuracy and authenticity[1–4].

摘要：Biomedical field has been seeking a feasible standard drug screening system consisting of 3D tumor model array for drug researching due to providing sufficient samples and simulating actual in vivo tumor growth situation,which is still a challenge to rapidly and uniformly establish ***,we propose a novel drug screening system,namely 3D tumor array chip with“layer cake”structure,for drug *** gelatin methacryloyl hydrogel droplets(~0.1μL)containing tumor cells can be automatically deposited on demand with electrohydrodynamic 3D *** conductive membrane is introduced as a chip basement for preventing charges accumulation during fabricating and convenient observing during *** chambers formed by stainless steel and silicon interlayer is convenient to be assembled and *** this chip is compatible with the existing 96-well culturing plate,the drug screening protocols could keep the same as *** properties of this chip,namely printing stability,customizability,accuracy,microenvironment,tumor functionalization,are detailly *** a demonstration,it is applied for screening of epirubicin and paclitaxel with breast tumor cells to confirm the compatibility of the proposed screening system with the traditional screening *** believe this chip will potentially play a significant role in drug evaluation in the future.

摘要：High-accuracy motion trajectory tracking control of a pneumatic cylinder driven by a proportional directional control valve was considered. A mathematical model of the system was developed firstly. Due to the time-varying friction force in the cylinder, unmodeled dynamics, and unknown disturbances, there exist large extent of parametric uncertainties and rather severe uncertain nonlinearities in the pneumatic system. To deal with these uncertainties effectively, an adaptive robust controller was constructed in this work. The proposed controller employs on-line recursive least squares estimation(RLSE) to reduce the extent of parametric uncertainties, and utilizes the sliding mode control method to attenuate the effects of parameter estimation errors, unmodeled dynamics and disturbances. Therefore, a prescribed motion tracking transient performance and final tracking accuracy can be guaranteed. Since the system model uncertainties are unmatched, the recursive backstepping design technology was applied. In order to solve the conflicts between the sliding mode control design and the adaptive control design, the projection mapping was used to condition the RLSE algorithm so that the parameter estimates are kept within a known bounded convex set. Extensive experimental results were presented to illustrate the excellent achievable performance of the proposed controller and performance robustness to the load variation and sudden disturbance.