摘要：Objective:This study aims to evaluate the effects of a symptom management intervention(SMI)based on symptom management group sessions combined with a mobile health(mHealth)application(app)on the knowledge of symptom management,the certainty of symptom self-management,symptom severity,symptom distress,medication adherence,social support,and quality of life among persons living with HIV(PLWH)in ***:A parallel randomized controlled trial with 61 PLWH was conducted in Shanghai,*** participants in the control group(n¼30)downloaded the Symptom Management(SM)app according to their needs and preferences,and received routine *** participants in the intervention group(n¼31)were guided to download and use the SM app,and received four tailored weekly group sessions at routine *** group session lasted for approximately 2 h and targeted one of the major modules of the SM *** the outcomes were assessed at baseline and *** study was registered with the Chinese Clinical Trial Registry(ChiCTR1900024821).Results:The symptom management knowledge and certainty of symptom self-management were significantly improved after the intervention(all P0.05).Conclusion:The SMI could improve PLWH’s symptom management knowledge and certainty of symptom ***-center studies with larger sample sizes and longer follow-ups are needed to further understand the effects of SM app on ameliorating symptom severity and symptom *** innovative strategies are also needed to promote and maintain the sustainability of the SM app.