摘要：Arrhythmogenic right ventricular cardiomyopathy(ARVC)is a progressive disease characterized by adipose and fibrous replacement of the *** elevated testosterone levels have been implicated in the pathological process of ARVC,its exact contribution to cardiac fibrosis in ARVC remains *** this study,we analyzed the potential contribution of gender-based differences on the distribution of the low-voltage area in an ARVC cohort undergoing an electrophysiological study,which was indicated by feature ***,we established engineered cardiac spheroid models in vitro using patient-specific induced pluripotent stem cell(iPSC)-derived cardiomyocytes(iPSC-CMs)and iPSC-derived cardiac fibroblasts(icFBs).We elucidated the pathogenicity of abnormal splicing in the plakophilin-2(PKP2)gene caused by an intronic ***,pathogenic validation of the desmoglein-2(DSG2)point mutation further confirms the reliability of the ***,testosterone exacerbated the DNA damage in the mutated cardiomyocytes and further activated myofibroblasts in a chain *** conclusion,we designed and constructed an in vitro three-dimensionally-engineered cardiac spheroid model of ARVC based on clinical findings and provided direct evidence of the fibrotic role of testosterone in ARVC.

摘要：Solid oxide cells(SOCs)are emerging devices for efficient energy storage and ***,during SOC operation,gaseous chromium(Cr)species released from Fe-Cr alloy interconnect can lead to Cr deposition and poisoning of air electrodes,causing substantial degradation in electrochemical performance and compromising the longterm stability of *** mini-review examines the mechanism of Cr deposition and poisoning in air electrodes under both fuel-cell and electrolysis ***,emphasis is placed on the recent advancements in strategies to mitigate Cr poisoning,offering insights into the rational design and development of active and Cr-tolerant air electrodes for SOCs.

摘要：Several methods of interval mapping of QTLs underlying endosperm traits based on random hybridization designs and the triploid genetic model are proposed. The basic idea is: plants (or lines) from a population with known marker genotype information are randomly hybridized to generate a population of hybrid lines for endosperm QTL mapping; a mixture of seeds of each hybrid line is measured for the en- dosperm trait to get the mean of the line; then en- dosperm QTL mapping and effect estimation is per- formed using the endosperm trait means of hybrid lines and the marker genotype information of parental plants (or lines). The feasibility and efficiency of the methods are examined by computer simulations. Results show that the methods can precisely map endosperm QTLs and unbiasedly and efficiently es- timate the three effects (additive effect, first dominant effect, second dominant effect) of endosperm QTLs.

摘要：Rotational atherectomy is an effective treatment for severe vascular calcification obstruction,and relies on high-speed grinding(typically 130,000–210,000 r/min)with miniature grinding tools to remove calcified tissue and restore blood ***,reports of intraoperative complications are common because of the grinding force,temperature,and debris directly acting on the body during the grinding process,which can easily cause damage to *** this study,three novel grinding tools were designed and fabricated and a series of experiments have been conducted to analyze the effects of tool geometry and parameters on grinding performance,that is,force,temperature,and specimen surface *** results show that these tools can effectively remove simulated calcified tissue and that they have two motions,rotation and revolution,in the *** higher rotational speeds,grinding force and temperature increase noticeably,while the amount of debris decreases *** addition,by observing the surface morphology of the specimens,we concluded that the material removal rate per unit time is influenced by both rotational speed and tool geometry,and that high rotational speed and a rough tool surface can improve the material removal rate efficiently.

摘要：In recent years,actuators based on carbon nanotube（CNT） or graphene demonstrate great potential applications in the fields of artificial muscles,smart switches,robotics,and so *** electrothermal and photothermal bending actuators based on CNT/graphene and polymer composites show large bending actuations,which are superior to traditional thermaldriven ***,the influence of material parameters（thickness,temperature change,etc.） on the actuation performance needs to be further studied,because it is a critical point to the design and fabrication of high-performance *** this work,finite element analysis（EEA） is employed to simulate the actuation performance of CNT/polymer actuator,which has a bilayer *** main focus of this work is to design and to optimize material parameters by using computational *** simulation results show that each layer thickness of actuator has an important influence on the actuation deformation.A maximum curvature of 2.7 cm^（-1） is obtained by simulation,which is much larger than most of the actuator curvature reported in previous *** is more,larger temperature change and larger difference of coefficient of thermal expansion（CTE） between two layers will result in larger bending *** study is expected to provide valuable theoretical reference for the design and realization of CNT-based thermal actuator with ultra-large actuation performance.

摘要：Based on the 1,3-dipolar cycloaddition of azomethine ylide generated in situ from aldehyde and sarcosine attached to C60,two novel benzo-15-crown-5/C60 dyads with a different linking chain in each were designed and synthesized in yields of 30％ and 38％,*** was found that their UV-Vis absorption spectra could be regulated hypsochromically by metal ions *** long and soft linking chain was favorable for cooperate interaction of crown ether unit and C60 unit.

摘要：Considering that the controller parameters are of additive norm-bounded uncertainties when realized, a design method of robust non-fragile H-infinity controller for uncertain systems based on Delta operator theory is illustrated in this paper. A sufficient and necessary condition of the existence for the controller is given, which is presented in LMI forms. Finally, the designed method is used in the speed control system of a permanent magnet linear synchronous motor （PMLSM）. With the designed controller, the resulting speed closed-loop system is still stable and has the expected Hinfinity performance even if the sample period is reduced and the parameters of the controller and the controlled object are varied. The results show that the designed method is effective.

摘要：Selective hydrodeoxygenation of lignin derivatives into aromatic compounds is a promising route for the upgrading of lignin *** carbide catalysts have exhibited excellent selectivity in hydrodeoxygenation reactions,while their structure-activity relationship is still in ***,a liquid-phase atomic layer deposition method was employed to synthesize W_(2)C/SiO_(2) catalysts with uniform and size-controllable W_(2)C *** gas-phase hydrodeoxygenation of lignin-derived m-cresol at 350℃,these W_(2)C/SiO_(2) catalysts showed superior toluene selectivities(>95%)regardless of the W_(2)C particle *** optimal W_(2)C particle size of~7 nm was obtained for achieving the highest W_(2)C-based hydrodeoxygenation *** contrast,the turnover rate per surface W site increased almost monotonously as the W_(2)C particle size increased within 0.7-15 nm,attributable to high-index planes appeared on the larger W_(2)C *** effects of m-cresol and H_(2),taken together with temperature-programmed desorption of probe molecules and theoretical treatments,further indicate that the W_(2)C surface is nearly saturated by adsorbed m-cresol or its derivates under the reaction condition and the H-addition of the C7H7*intermediate to form toluene,instead of the initial C-O cleavage in m-cresol,acts as the rate-determining step.A side-by-side comparison between W_(2)C(102)and W_(2)C(001)catalyst surfaces in theoretical simulations of m-cresol hydrodeoxygenation verifies that high-index planes can stabilize kinetically-relevant transition states more effectively than the low-index ones,as a result of more available less-coordinated active sites on the *** above findings bring new mechanistic insights into the site requirements of supported W_(2)C nanocatalysts,distinct from those metal-catalyzed hydrodeoxygenation of oxygenates.

摘要：In this work, the intra-EDA method, which is a recently developed energy decomposition analysis scheme for intramolecular non-covalent interaction is extended from gas phase to solvated environment. It is the first analysis scheme that performs analysis for intramolecular interaction in solution. By fragmentation scheme, a molecule is divided into intramolecular interacting fragments and environmental fragments via single bond homolysis breaking. The solvent effect is taken into account by implicit solvation model. Intramolecular interaction free energy is estimated as the separated treatment of inter-fragment interactions in dielectric environment. The analysis results highlight the importance of solvent effects to intramolecular non-covalent interaction.

摘要：We evaluate the hydrogen depletion ability of the hydrogen depletion system for Chinese Pressurized Reactor 1000(CPR1000), which has been applied in nuclear power plants with pressurized water reactors;moreover, we introduce a new device that can continuously monitor hydrogen concentration inside the CPR1000 containment building. Experimental studies show that a moveable hydrogen autocatalytic recombiner alone can sufficiently deplete hydrogen under the condition of a design-basis accident, and 33 passive autocatalytic recombiners placed in the areas of high hydrogen concentration satisfy the hydrogen depletion requirements under the condition of a beyond-design-basis ***, the hydrogen concentration monitoring system is designed and installed based on the approach of detecting the temperature increase caused by the catalytic reaction of hydrogen. In conclusion, the hydrogen depletion capacity of the CPR1000 meets the requirements, and the system's safety can be enhanced by the improved hydrogen concentration monitoring system.