摘要：Zinc and its alloys provide a scalable alternative to the list of biodegradable metals due to its moderate degradation rates and biocompatible degradation ***,one of the challenges impeding their clinical applications is the uncontrollable and unstable interfacial reactions between zinc implants and the corrosive *** this study,we report a facile synthesis of metal-organic framework(MOF)nanocrystal coating with tunable thickness on the high-strength Zn-0.8Li alloy matrix for controlled *** as-obtained dense and uniform MOF nanocrystals form a strong connection with the zinc matrix via coordination bond so as to maintain the mechanical properties,and meantime provide highly rough surfaces exhibiting tunable *** varied MOF coating thus regulate the interface structure between the zinc matrix and corrosive media to control the degradation *** antibacterial activity and biocompatibility are also achieved because of the unique topology morphologies,surface superhydrophilicity,as well as the dynamic Zn^(2+)*** study sheds valuable lights on the design of MOF-functionalized metal implants for practical use and also triggers extensive applications of MOF in biomaterials.

摘要：In recent years, image-based anti-aliasing techniques have been widely investigated in real-time computer graphics. Compared to traditional routine of anti-aliasing, image-based methods, which combined with deferred shading, can efficiently decouple anti-aliasing step from standard graphics pipeline. However, most of the existing image-based methods consume video memory, bandwidth and computation resources heavily. In this paper, we propose an optimized anti-aliasing method, which can efficiently reduce the multi-sampling rate by a multi-sampling mask. We carefully designed the rendering system to avoid serial execution on branch divergence, by utilizing both modern GPU’s features and latest shader model. Experimental results demonstrate that our method can achieve high-quality synthesized image with real-time performance.

摘要：Custom-made esthetic finger prostheses, which are used for rehabilitation of patients with missing or impaired fingers, have been fabricated manually. However, such fabrication is time-consuming and requires manual skill. Here we propose a computer-aided method for fabricating finger pros-theses to save time and allow fabrications that do not require considerable manual skill. In this method, the dimensions of a patient’s healthy finger on the contralateral hand are first measured using a caliper. Using these dimensions, a three-dimensional model is constructed for fabricating a prosthesis for the patient’s impaired finger. Using the 3D model, a mold is designed using 3D modeling tools and a computer-aided design system. The resulting mold is then fabricated using a 3D printer. A finger prosthesis is fabricated by pouring silicone resin into the mold. A finger prosthesis for a volunteer was experimentally fabricated according to the proposed method. To evaluate the size and shape of the finger prosthesis, the difference between the finger prosthesis and the original finger of the volunteer was analyzed. Because the average difference between them was 0.25 mm, it was concluded that the proposed method could be used to fabricate a finger prosthesis of adequate size and shape.

摘要：DNA methyl transferase(DNMT) and histone deacetylase(HDAC) are well recognized epigenetic targets for discovery of antitumor *** this study,we designed and synthesized a series of nucleoside base hydroxamic acid derivatives as DNMT and HDAC dual *** assays and enzymatic inhibitory activity tests indicated that compound 204 exhibited potent DNMT1 and HDAC1/6 inhibitory potency simultaneously in enzymatic levels and at cellular levels,inducing hypomethylation of p16 and hyperacetylation of histones H_(3) K9 and H4 ***,204 remarkably inhibited proliferation against cancer cells U937 by prompting G0/G1 cell cycle *** docking models explained the functional mechanism of 204 inhibiting DNMT1 and *** studies on metabolic profiles revealed that 204 showed desirable stability in liver *** study suggested that 204 inhibiting DNMT and HDAC concurrently can be a potential lead compound for epigenetic cancer therapy.

摘要：A series of Co-imbedded zeolite-based catalysts were synthesized following a facile solvent-free grinding *** catalytic performance for direct syngas conversion to gasoline range hydrocarbons was compared with their counterpart Co-impregnated zeolite-based *** transformation of solid raw materials to targeted zeolite was confirmed by XRD,SEM,STEM,and N2 physisorption *** in-depth study of acidic strength and acidic site distribution was conducted by NH3-TPD and Py-IR *** strength showed a pivotal role in defining product ***@S1,with the weakest acidic strength of silicalite-1 among three types of zeolites,evaded over-cracking of product and exhibited the highest gasoline and isoparaffin selectivity(≈70%and 30.7%,respectively).Moreover,the solvent-free raw material grinding route for zeolite synthesis accompanies several advantages like the elimination of production of wastewater,high product yield within confined crystallization space,and elimination of safety concerns regarding high pressure due to the absence of the *** and easiness of the solvent-free synthesis route together with promising catalytic performance strongly support its application on the industrial scale.

摘要：为了研究以海绵作填料进行厌氧氨氧化反应的可行性,在某上流式厌氧固定床反应器中利用人工配制高NH4-N水进行了实验研究.结果表明,利用人工配制废水作为实验用水,在水力停留时间为3.1 h,容积负荷为3.5 kg/(m3.d)时,总氮的去除率可达到75%.稳态运行时,反应器内部呈碱性,NH4-N去除量、NO2-N去除量与NO3-N的生成量之间的比值为1∶1.21∶0.19.以海绵作填料,与其他填料(新型丙烯酸纤维、聚乙烯醇凝胶)相比,所需启动时间短,操作简便,并能在较短的水力停留时间内高效地处理高浓度的NH4-N废水.

摘要：In this paper, we report the design and moleculardocking study of analogues of antimycin A3 as inhibitors of anti-apoptotic Bcl-2 of breast cancer. Twenty designed compounds and the original antimycin A3 were docked based on their interaction with breast tumor receptor binding target Bcl-2. The docking resulted in the five top-ranked compounds, namely, compounds 11, 14, 15, 16, and 20, which have a lower G binding energy, better affinity and stronger hydrogen bonding interactions to the active site of Bcl-2 than antimycin A3. Among those five top-ranked compounds, analogue compounds 11 and 14, which have an 18-membered tetralactone core and 18-membered tetraol core, respectively, exhibited the strongest hydrogen bond interaction, formed high stability conformation, and demonstrated the greatest inhibitory activity on the catalytic site of Bcl-2.

摘要：In this paper, an approach of roads network extraction from high resolution satellite images is presented. First, the approach extracts road surface from satellite image using one-class support vector machine （SVM）. Second, the road topology is built from the road surface. The last output of the approach is a series of road segments which is represented by a sequence of points as well as the topological relations among them. The approach includes four steps. In the first step one-class support vector machine is used for classifying pixel of the satellite images to road class or non-road class. In the second step filling holes and connecting gaps for the SVM＇s classification result is applied through mathematical morphology close operation. In the third step the road segment is extracted by a series of operations which include skeletonization, thin, branch pruning and road segmentation. In the last step a geometrical adjustment process is applied through analyzing the road segment curvature. The experiment results demonstrate its robustness and viability on extracting road network from high resolution satellite images.

摘要：本文研究了一种新型低密度(~6.24 g cm^(-3))双相AlTiVCoNi高熵合金,其组织结构由有序L21高熵金属间化合物、无序体心立方结构和纳米L21相多层次结构构成.该合金在1200℃+24 h热处理下未发生相结构转变,在此条件下具有优异的高温相结构稳定性,其铸态和热处理态的压缩屈服强度相当,达到~1.6 GPa.另外,该合金在室温和600℃条件下表现出了优异的强塑性匹配和优异的比屈服强度,分别达到了约261和210 MPa g^(-1)cm^(3).该合金的超高强度主要源于有序L21相与体心立方相的半共格界面导致的一种强相结构稳定性和多层次结构的复合强化机制.该合金在800和1000℃压缩过程中出现了动态再结晶软化,使得其高温强度有所降低.这种“具有半共格界面L21+体心立方+纳米L21颗粒”的多层次结构设计为开发新型低密度耐高温高熵合金提供了一种新设计思路.

摘要：Solar-driven photoelectrochemical(PEC) water splitting is a promising technology for sustainable hydrogen production, which relies on the development of efficient and stable photoanodes for water oxidation reaction. The thickness and microstructure of semiconductor films are generally crucial to their PEC properties. Herein, three-dimensional(3D) interconnected nanoporous Ta3N5 film photoanodes with controlled thickness were successfully fabricated via galvanostatic anodization and NH3 nitridation. The porous Ta3N5 nanoarchitectures(NAs) of 900 nm in thickness showed the highest PEC performance due to the optimal lightharvesting and charge separation. Compared with the holeinduced photocorrosion, the electrochemical oxidation at high anodic potentials resulted in severer performance degradation of Ta3N5. Although the surface oxide layer on deteriorated Ta3N5 photoanodes could be removed by NH3 re-treatment,the PEC performance was only partially recovered. As an alternative, anchoring a dual-layer Co(OH)x/Co OOH co-catalyst shell on the porous Ta3N5 NAs demonstrated substantially enhanced PEC performance and stability. Overall, this work provides reference to controllably fabricate 3D nanoporous Ta3N5-based photoanodes for efficient and stable PEC water splitting via optimizing the light absorption, hole extraction,charge separation and utilization.