摘要：The low temperature,high salt content,and bacterial composition of a seawater environment can induce severe infections in open wounds,thus impeding wound *** date,numerous wound dressings have been developed for injuries and various antibacterial ***,ordinary antibacterial strategies could not provide long-term resistance to infections and could not promote wound ***,we proposed a strategy for enhancing resistance to seawater immersion wound infection by killing bacteria and delivering bacterial antigens in ***,MXene-embedded tannin-Eu^(3+)(M@TA-Eu)particles were constructed to effectively alleviate injuries infected through seawater immersion and persistently fight infection by forming in situ bacterial vaccines and immune *** the particle,the platform composed of TA and Eu3+exhibited provascularization and antigen presentation *** with near-infrared photothermal effect were introduced to kill the bacteria,promote the recruitment of antigen presentation cells,and ultimately enhance vaccination *** results showed that the particles not only effectively accelerated the healing of injuries by relieving wound inflammation and inhibiting bacteria but also produced a potent vaccination by forming in situ bacterial ***,the M@TA-Eu particles are novel materials for high-grade anti-infection dressing.

摘要：Immune evasion behavior and immunosuppressive characteristics of tumor extensively impedethe immune initiation effect of therapy triggered immunogeniccell death (ICD). In this work, a carrier-adjuvantedimmunostimulator (designated as CoCeC) is developed toboost photodynamic immunotherapy by downregulatingprogrammed death ligand 1 (PD-L1) and impairing adenosinetriphosphate (ATP) hydrolysis. Among these, the crosslinkedchitosan oligosaccharide is applied as the drug carrier fordelivery of Ce6 and Ceritinib, which also serves as an immuneadjuvant to downregulate PD-L1. Meanwhile, the robustphotodynamic therapy (PDT) of CoCeC exhibits lethal toxicityagainst tumor cells to induce ICD and release damage-associated molecular patterns (DAMPs), which can also impairATP hydrolysis by blocking CD39. In vitro and in vivo resultsdemonstrate the robust therapeutic efficacy of CoCeC tosuppress primary tumor growth and activate a superior immune elimination against lung metastasis by amplifying theimmune initiation of ICD with the assistance of immune *** work provides a self-adjuvanted strategy to enhance the immune response of therapy induced ICD, which ispromising to activate systemic antitumor immunity in consideration of the complicated immunosuppressive factors.

摘要：The sensing capabilities of a soft arm are ofparamount importance to its overall performance as they allow precise control of the soft arm and enhance its interactionwith the surrounding environment. However, the actuationand sensing of a soft arm are not typically integrated into amonolithic structure, which would impede the arm’s movement and restrict its performance and application scope. Toaddress this limitation, this study proposes an innovativemethod for the integrated design of actuator structures andsensing. The proposed method combines the art of kirigamiwith soft robotics technology. In the proposed method, sensorsare embedded in the form of kirigami structures into actuatorsusing laser cutting technology, achieving seamless integrationwith a soft arm. Compared to the traditional amanogawakirigami and fractal-cut kirigami structures, the proposedmiddle-cut kirigami (MCK) structure does not buckle duringstretching and exhibits superior tensile performance. Based onthe MCK structure, an advanced interdigitated capacitivesensor with a high degree of linearity, which can significantlyoutperform traditional kirigami sensors, is developed. Theexperimental results validate the effectiveness of the proposedsoft arm design in actual logistics sorting tasks, demonstratingthat it is capable of accurately sorting objects based on sensorsignals. In addition, the results indicate that the developedcontinuum soft arm and its embedded kirigami sensors havegreat potential in the field of logistics automation *** work provides a promising solution for high-precisionclosed-loop feedback control and environmental interaction ofsoft arms.

摘要：Wireless millirobots engineered to infiltrate intricate vascular networks within living organisms,particularly within constricted and confined spaces,hold immense promise for the future of medical ***,with their multifaceted and intricate designs,some robots often grapple with motion and functionality issues when confronted with tight spaces characterized by small cross-sectional *** this study,drawing inspiration from the high aspect ratio and undulating swimming patterns of snakes,a millimeter-scale,snake-like robot was designed and fabricated via a combination of extrusion-based four-dimensional(4D)printing and magnetic-responsive intelligent functional inks.A sophisticated motion control strategy was also developed,which enables the robots to perform various dynamic movements,such as undulating swimming,precise turns,graceful circular motions,and coordinated cluster movements,under diverse magnetic field *** a potential application,the snake robot can navigate and release drugs in a model coronary intervention vessel with tortuous channels and fluid *** novel design and promising applications of this snake robot are invaluable tools in future medical surgeries and interventions.

摘要：In this paper,we investigate two competing pay-tv platforms or free-to-air media platforms that consist of two groups of agents:viewers and *** pay-tv platforms can receive revenues from charging viewers pay-per-view prices and advertising,while the free-to-air platforms can only obtain all incomes from *** discuss and compare advertising intensities and program content provisions of the two competing media *** findings show that if the extent to which viewers dislike advertising(the nuisance for advertising)is more massive than the marginal benefit that advertisers receive from an additional viewer,the pay-tv stations tend to maximally differentiate their program content and charge the viewers higher pay-per-view *** the nuisance approaches to the marginal benefit,however,both stations should offer similar program content,and charge the viewers lower prices under certain ***,if both platforms provide duplicated content,they should subsidize the *** contrast,we show that the free-to-air media platforms never duplicate program content with a positive nuisance for advertising,and tend to offer maximal differentiated content if the nuisance is sufficiently ***,we reveal that if the viewers greatly dislike advertising(care less about advertising),the advertising volume of the pay-tv platforms is lower(higher)than that of the free-to-air ***,we extend our base model to the case in which a pay-tv platform competes against a free-to-air station,and numerically show that the profit of the pay-tv platform may be larger or smaller than that of the free-to-air station.

摘要：The A–D–A′–D–A-type non-fused ring electron acceptors(NFREAs),consisting of electron-donating unit(D)as the bridge to link electron-accepting units(A and A′),have emerged as promising electron acceptors for organic solar cells(OSCs)and organic photodetectors(OPDs).As the units are linked by the carbon–carbon single bonds,these electron acceptors generally possess feasible synthesis and tunable optoelectronic ***,the recent progress of A–D–A′–D–A-type NFREAs is reviewed,including molecular design,device performance,structure–property relationships,and their applications in OSCs and ***,we discuss the challenges and propose the perspectives for the further development of A–D–A′–D–A-type NFREAs.

摘要：The recently emerging laser-induced graphene(LIG)technology,with one-step processing and designable features,has been widely used in the fabrication of wearable/portable ***,by taking inspiration from kirigami,we designed a stretchable supercapacitor(SC)step by step through controlling laser induction and cutting process on the polyimide(PI)film,with the use of one single CO_(2) laser ***,the carbonized basic geometric units of lines were produced on PI films to investigate the processing-structure ***,the complex photothermal conversion and heat transfer progress involved in the carbonized process were simulated by a photothermal *** experimental and theoretical results suggested that the laser power,scan rate and focus condition have great influence on the size,shape and morphology of the carbonized ***,we optimized the parameters of laser induction and cutting process to fabricate the kirigami-inspired SCs with reliable electrochemical properties and editable mechanical flexibility,showing great potential in the field of flexible electronics.

摘要：In this paper, we extend a novel unconstrained multiobjective optimization algorithm, so-called multiobjective extremal optimization （MOEO）, to solve the constrained multiobjective optimization problems （MOPs）. The proposed approach is validated by three constrained benchmark problems and successfully applied to handling three multiobjective engineering design problems reported in literature. Simulation results indicate that the proposed approach is highly competitive with three state-of-the-art multiobjective evolutionary algorithms, i.e., NSGA-11, SPEA2 and PAES. Thus MOEO can be considered a good alternative to solve constrained multiobjective optimization problems.

摘要：Fail-safe topology optimization is valuable for ensuring that optimized structures remain operable even under damaged *** selectively removing material stiffness in patches with a fixed shape,the complex phenomenon of local failure is modeled in fail-safe topology *** this work,we first conduct a comprehensive study to explore the impact of patch size,shape,and distribution on the robustness of fail-safe *** findings suggest that larger sizes and finer distribution of material patches can yield more robust fail-safe ***,a finer patch distribution can significantly increase computational costs,particularly for 3D *** keep computational efforts tractable,an efficient fail-safe topology optimization approach is established based on the framework of multi-resolution topology optimization(MTOP).Within the MTOP framework,the extended finite element method is introduced to establish a decoupling connection between the analysis mesh and the topology description *** examples demonstrate that the developed methodology is 2 times faster for 2D problems and over 25 times faster for 3D problems than traditional fail-safe topology optimization while maintaining similar levels of robustness.

摘要：With the convergence of high-performance computing(HPC),big data and artificial intelligence(AI),the HPC community is pushing for"triple use"systems to expedite scientific ***,supporting these converged applications on HPC systems presents formidable challenges in terms of storage and data management due to the explosive growth of scientific data and the fundamental differences in I/O characteristics among HPC,big data and AI *** this paper,we discuss the driving force behind the converging trend,highlight three data management challenges,and summarize our efforts in addressing these data management challenges on a typical HPC system at the parallel file system,data management middleware,and user application *** HPC systems are approaching the border of exascale computing,this paper sheds light on how to enable application-driven data management as a preliminary step toward the deep convergence of exascale computing ecosystems,big data,and AI.