摘要：A new compound based on immobilizing of Pd6(RuL3)8(BF4)28 (L=2-(pyridin-3-yl)-1H-imidazo [4,5-f][1,10]-phenanthroline) cage (MOC-16) on g-C3N4 was synthesized. Infrared spectrum and powder X-ray diffraction were used to characterize structure of hybrid MOC-16/g-C3N4, as well as UV-vis absorption spectrum and X-ray photoelectron spectroscopy were carried out to unveil photocatalytic mechanism. With the introduction of MOC-16, the absorption edge of MOC-16/g-C3N4 in UV-vis spectrum extended apparently to long-wavelength region compared with pristine g-C3N4. H2 evolution yielded with MOC-16/g-C3N4 in aqueous solution containing TEOA was much higher than that with RuL3/g-C3N4, Pd/RuL3/g-C3N4 and mixture of MOC-16 and g-C3N4, showing that the octahedral cage structure with high-efficient electron transfer and the interface interaction between MOC-16 and g-C3N4 were significant for improvement of H2 evolution.

摘要：High interfacial energy Li^(0)-electrolyte interface contributes to larger Li^(0) nucleation embryos and a more stable interface,so the interfacial energy is essential for highly reversible Li^(0) deposition/***,a high interfacial-energy artificial solid electrolyte interphase(SEI)with rich LiF embedded in lithiated poly-2-acrylamido-2-methylpropane sulfonic acid(PAMPS-Li)network is designed to realize favorable Li^(0) nucleation and rapid desolvation of Li+*** Li-F bonds in LiF(001)exhibit stronger ion-dipole interactions with Li atoms,offering higher interfacial *** the growth surface energy and total interfacial energy of Li^(0) are balanced,the high interfacial energy SEI with abundant LiF can promote the formation of larger Li^(0) nucleation *** addition,the PAMPS-Li with immobilized anions presents weaker interaction with Li^(0) and possesses higher polymer-Li interfacial energy,and its amide and sulfonic acid groups exhibit higher binding energies with Li^(+).Therefore,PAMPS-Li can easily promote the Li+to escape from the solvent sheath and weaken the desolvation energy *** highly reversible Li^(0) deposition behavior with restricted side reactions is achieved based on the synergistic modification of high interfacial energy SEI with *** importantly,lifespan of multi-layered Li^(0) pouch cell(330 Wh kg-1)with a low N/P ratio(1.67)is over 100 cycles,verifying its potential practical application.

摘要：Human noroviruses(HuNoVs)are major foodborne pathogens that cause nonbacterial acute gastroenteritis *** the tissue-culture system for HuNoVs is not mature enough for routine detection of the virus,detection is mainly dependent on molecular approaches such as reverse transcription polymerase chain reaction(RT-PCR)and reverse transcription quantitative real-time polymerase chain reaction(RTqPCR).The widely used primers and probes for RT-qPCR were established in the early *** HuNoVs are highly variant viruses,viral genome mutations result in previously designed primers and/or probes that were perfectly matched working less efficiently over *** this study,a new duplex RT-qPCR(ND-RT-qPCR)was designed for the detection of genogroup Ⅰ(GⅠ)and genogroup Ⅱ(GⅡ)HuNoVs based on an analysis of viral sequences added in the database after *** long transcribed viral RNAs,the results demonstrate that the sensitivity of ND-RT-qPCR is as low as one genomic copy for both GⅠ and GⅡ *** performance of ND-RT-qPCR was further evaluated by a comparison with the commonly used Kageyama primer/probe sets for RT-qPCR(Kageyama RT-qPCR)for 23 HuNoV-positive clinical *** five GⅠ samples were registered as positive by ND-RT-qPCR,whereas only two samples were registered as positive by Kageyama *** 18 GⅡ samples were registered as positive by ND-RT-qPCR,while 17 samples were registered as positive by Kageyama *** sensitivity reflected by the quantification cycle(Cq)value was lower in ND-RT-qPCR than in Kageyama *** data suggest that ND-RT-qPCR could be a good fit for the detection of current strains of HuNoVs.

摘要：局部电荷的强离域和强偶极矩是影响共价有机框架(COFs)基光催化剂催化析氢性能的两个关键因素.然而,基于精确的调控结构模型来系统研究这种构效关系的报告相对较少.本研究提出了一种新的策略,通过合理的设计,制备了三种三芴酮基COFs,通过在分子水平上调控单体的结构和偶极来提高局部电荷离域指数.我们重点研究这三种三芴酮基COF的局部电荷离域与光催化性能之间的构效关系.在不同三芴酮基COF中,1,3,5-三(对甲酰基苯基)苯基COF(TeTpb-COF)展现出21.6 mmol g^(-1)h^(-1)的最高析氢速率,与2,4,6-三(4-醛基苯基)-1,3,5-三嗪基COF(TeTt-COF,0.2mmol g^(-1)h^(-1))相比,光催化析氢性能提高了108倍.这种性能的增强可归因于其强大的分子内置电场提高了供体-受体嵌段单元中光生电荷的有效分离效率.这项工作证实了调整构建块可以极大增强三芴酮基COFs中的局部偶极矩,从而显著改善光催化析氢性能.构建模块的调控策略为创建高效的新型COF基光催化析氢平台提供了新机会.

摘要：Objective:Osteoradionecrosis of the jaws(ORNJ)is among the most serious oral complications of head and neck cancer treatment with radiation *** study aimed to examine the level of symptom distress and interference of ORNJ in head and neck cancer patients in ***:A cross-sectional study was conducted to profile patient reported symptom *** hospitalized ORNJ patients were *** completed the MD Anderson Symptom Inventory-Head and Neck Module-Chinese ***:The percentage of participants who reported that they experienced at least one type of symptom was 97.9%,and 85.2%patients reported *** 10 most severe symptoms were as follows:limited mouth opening,problem with teeth/gums,difficulty swallowing/chewing,dry mouth,oral malodor,difficulty with voice/speech,dental ulcer,tinnitus/ear obstruction,skin pain/burning/rash,and difficulty *** problem of limited mouth opening was more severe in patients with longer time to onset of ORNJ after *** interference of patients positively correlated with core symptoms(r=0.612),head and neck symptoms(r=0.709),and ORNJ symptoms(r=0.440)(P<0.01).The longer time to the onset of ORNJ after radiotherapy was positively and significantly correlated with symptom distress(r=0.479,P<0.001),and mouth opening correlated negatively with symptom distress(r=-0.298,P=0.003).Conclusions:ORNJ patients suffered mainly from limited mouth opening and other maxillofacial *** problem of limited mouth opening was more severe in patients with longer time to onset of ORNJ after *** patients commonly had symptom distress,which influenced their quality of life.

摘要：A pot experiment was conducted to study the effects of biochar on physiological characteristics and accumulation of Cd and Pb of Lonicera japonica in Cd and Pb contaminated *** results showed that adding 2%~16%biochar could significantly increase the net photosynthetic rate,chlorophyll content and root activity of Lonicera japonica,and significantly reduce its SOD *** 6%~16%biochar was added,the contents of Cd and Pb in roots and stems of Lonicera japonica decreased significantly;when 2%~16%biochar was added,the contents of Cd and Pb in the leaves and flowers of Lonicera japonica decreased *** more than 8%biochar can reduce the content of Cd and Pb in Lonicera japonica to a safe range level.

摘要：Inspired by MXene nanosheets and their regulation of surface functional groups,a series of Ti_(2)C‐based single‐atom electrocatalysts(TM@Ti_(2)CT_(x),TM=V,Cr,Mn,Fe,Co,and Ni)with two dif‐ferent functional groups(T=–O and–S)was *** CO_(2)RR catalytic performance was stud‐ied using well‐defined ab initio *** results show that the CO_(2) molecule can be more readily activated on TM@Ti_(2)CO_(2) than the TM@Ti_(2)CS_(2) *** charge analysis reveals that the Ti_(2)CO_(2) substrate is involved in the adsorption reaction,and enough electrons are injected into the 2π*u orbital of CO_(2),leading to a V‐shaped CO_(2) molecular configuration and partial negative charge *** V‐shaped CO_(2) further reduces the difficulty of the first hydrogenation reac‐tion *** calculatedΔG of the first hydrogenation reaction on TM@Ti_(2)CO_(2) was significantly lower than that of the TM@Ti_(2)CS_(2) ***,the subsequent CO_(2) reduction pathways show that the UL of the potential determining step on TM@Ti_(2)CS_(2) is smaller than that of TM@Ti_(2)CO_(2).Combining the advantages of both TM@Ti_(2)CS_(2) and TM@Ti_(2)CO_(2),we designed a mixed functional group surface with–O and–S to anchor TM *** results show that Cr atoms an‐chored on the surface of mixed functional groups exhibit high catalytic activity for the selective production of *** study opens an exciting new avenue for the rational design of highly selec‐tive MXene‐based single‐atom CO_(2)RR electrocatalysts.

摘要：β-Glucuronidase(GUS)plays a key role in tumor initiation,metastasis,and progression,and thus,has been proposed as a promising cancer *** this study,we designed an enzyme-activatable near-infrared(NIR)fluorescent probe(DCM-βGlcA)for the rapid and accurate detection of GUS activity in vitro,in vivo and ex *** DCM-βGlcA was prepared by linking a glucuronic acid residue to dicyanomethylene-4 H-pyran(DCM).This probe exhibited significant light-up NIR fluorescent signals at 680 nm after reacting with GUS and the Stokes shift could reach 150 *** DCM-βGlcA showed a high sensitivity toward GUS and an excellent linear relationship at concentrations ranging between 0 and 4 U L^(-1)(R^(2)=0.9974)with the limit of detection as low as 0.19 U L^(-1).We used the DCM-βGlcA to identify GUS serum levels in both cancer patients and healthy individuals with a similar accuracy as that of an enzyme-linked immunosorbent assay(ELISA)while being easier and faster to ***,the DCM-βGlcA was used for tracking endogenous GUS in living cells,thereby discriminating GUSoverexpressed liver cancer from normal ***,the DCM-βGlcA was able to detect and image endogenous GUS in liver cancer tissue and tumor-bearing mouse *** findings demonstrate the potential of the DCM-βGlcA as a promising tool for detecting and monitoring GUS activity in preclinical applications.

摘要：In contrast to heterogeneous network frameworks(e.g.,covalent organic frameworks and metal‐organic frameworks)and porous organic polymers,porous organic cages(POCs)are soluble molecules in common organic solvents that provide significant potential for homogeneous ***,we report a triphenylphosphine‐derived quasi‐porous organic cage(denoted as POC‐DICP)as an efficient organic molecular cage ligand for Rh/PPh_(3) system‐catalyzed homogeneous hydroformylation ***‐DICP not only displays enhanced hydroformylation selectivity(aldehyde selectivity as high as 97%and a linear‐to‐branch ratio as high as 1.89)but can also be recovered and reused via a simple precipitation method in homogeneous reaction *** speculate that the reason for the high activity and good selectivity is the favorable geometry(cone angle=123.88°)and electronic effect(P site is relatively electron‐deficient)of POC‐DICP,which were also demonstrated by density functional theory calculations and X‐ray absorption fine‐structure characterization.

摘要：The vicious cycle between tumor cell proliferation and bone resorption remarkably elevates the progression and metastasis of bone ***,we fabricated polyethylene glycol-conjugated alendronate-functionalized and chloroquine(CQ)-loaded polydopamine nanoparticles(PPA/CQ)for efficient treatment of bone tumors via breaking the vicious *** nanoparticles were efficiently accumulated to the bone tissues,especially the osteolytic lesions around *** released from PPA/CQ inhibited osteoclastogenesis via preventing the degradation of tumor necrosis factor(TNF)receptor-associated receptor 3 to attenuate the osteolysis in bone *** the other hand,CQ blocked the autophagy in cancer cells,resulting in improved photothermal killing of cancer ***,the in vivo experiment revealed that PPA/CQ-associated treatment efficiently inhibited both tumor growth and *** work suggests that autophagy inhibition-associated photothermal therapy could be a promising strategy for treating malignant bone tumors.