摘要：In the pragmatics literature the relationship between mitigation and pragmatic empathy remains largely an underexplored,or even worse,a controversial issue,giving rise to the formulation of divergent views of empathy in *** I treat empathy as a working mechanism providing a general explanation of how mitigation works,Caffi(1999;2007;2013)adopts a“paradox”view on *** purpose of this paper is to track down the sources of divergence by comparing and contrasting our conceptualizations of *** is found that the biggest difference lies in the treatment of ***,although I argue in favor of my empathic view,I see it as complementary,rather than contradictory,to Caffi’s *** relationship between mitigation and politeness is revisited with its implications for teaching pragmatics briefly discussed.

摘要：Electrochemical reduction from nitrate into ammonia is a chance for nitrate removal from drinking water,while at higher concentrations,this 8-electron reduction process could even become relevant for energy storage,high conversions and low onset potentials ***,we report the synthesis and analysis of a NiFe_(2)O_(4)/C-MS hybrid system made by a molten-salt strategy where the Ni-Fe oxide spinel nanoparticles act as the active center for electrochemical nitrate(NO_(3)−)reduction reaction,while the microporous carbon serves as a conductive support to form a cohesive electrode *** NiFe_(2)O_(4)/C-MS catalyst achieves a maximum NH3 yield rate of 5.4 mg mgcat.^(−1)h^(−1)and Faradaic efficiency of 98%at−0.6 V versus reversible hydrogen *** NiFe_(2)O_(4)nanoparticles buried into microporous carbon,the onset potential decreases *** propose that this reduction originates from charge redistribution in NiFe_(2)O_(4)in the electronic heterojunction with carbon,while enhanced electrolyte diffusion in microporous carbon facilitates high conversion *** functional theory calculations clarify the low energy barrier on NiFe_(2)O_(4),highlighting the essential role of Ni in activating Fe *** COMSOL Multiphysics simulations demonstrate that the microporous curled carbon accelerates NO_(3)−transport and enhances adsorption on the reactive *** work offers insights for designing carbon-based nanocomposites for efficient nitrate reduction electrocatalysis.

摘要：A series of novel coumarin-stilbenes hybrids called 3-arylcoumarins were synthesized via Perkin reaction and evaluated as potential antitumor *** results showed that some compounds exhibited in vitro activity against KB,KV,MCF-7,MCF-7/ ADR cell lines to some *** 3a showed remarkable effect against KB tumor cells with an IC50 value of 5.18μmol/L.

摘要：Microorganisms have been the main sources for the production of *** of chemicals requires the development of low-cost and higher-yield *** this goal,microbial strains with higher levels of production should be first *** engineering has been used extensively over the past two to three decades to increase production of these *** in omics technology and computational simulation are allowing us to perform metabolic engineering at the systems *** combining the results of omics analyses and computational simulation,systems biology allows us to understand cellular physiology and characteristics,which can subsequently be used for designing ***,we review the current status of metabolic engineering based on systems biology for chemical production and discuss future prospects.

摘要：Ideological-political construction in English curriculum is to integrate outlook on the world,outlook on life,outlook on values,*** English language teaching and *** recent years,studies on ideological-political construction in middle school English curriculum have made some progress,with an emphasis on its significance and the strategies for its ***,there is still room for expansion in the research methods,research contents,and research perspectives.

摘要：Refractory alloys such as tungsten and molybdenum based alloys with high strength,thermal/electrical conductivity,low coefficient of thermal expansion and excellent creep resistances are highly desirable for applications in nuclear facilities,critical components in aerospace and defense ***,the serious embrittlement limits the engineering usability of some refractory alloys.A lot of research results indicate that the performances of refractory alloys are closely related to the physical/chemical status,such as the interface dimension,interface type,interface composition of their grain boundaries(GBs),phase boundaries(PBs)and other interface *** paper reviewed the recent progress of simulations and experiments on interface design strategies that achieve high performance refractory *** strategies include GB interface purifying/strengthening,PB interface strengthening and PB/GB synergistic *** details are provided on the design/fabrication strategy such as GB interface controlling,PB interface controlling and synergistic control of multi-scaled *** corresponding performances such as the mechanical property,thermal conductivity,thermal load resistance,thermal stability,irradiation resistance,and oxidation resistance are reviewed in the aspect to the effect of *** addition,the relationships between these interfaces and material properties are ***,future developments and potential new research directions for refractory alloys are proposed.

摘要：As one of Shakespeare＇s four great tragedies, King Lear stands as a classic masterpiece firmly in world literary history. The Lear story goes through many retellings, among which Jane Smiley＇s A Thousand Acres proves to be a successful one. Though exhibited from different perspectives, the two stories have something in common the ironies arising from father-daughter conflicts. In the way of an intertextual comparison, the paper analyzes the ironies from father-daughter conflicts with an aim of digging out deep meaning from behind in a new angle. It f＇mds out that the ironies shared by the two works help to increase the tragic atmosphere and reveal a lot of truths underneath the lines.

摘要：This paper takes an integrative approach to the communication and comprehension of humor from the perspectives of the humorist’s manipulation and the recipient’s vigilance informed by relevance *** is proposed that,in order to communicate humor,the humorist manipulates the recipient’s expectation of relevance in the setup and in the punchline in two different but related ways:misleading and *** is also proposed that,in order to comprehend and appreciate humor,the recipient exercises vigilance against his/her own shallow processing in the setup and exercises vigilance for special cognitive effects in the *** this approach,humorous communication and comprehension is viewed as an interaction between manipulation and epistemic *** of manipulation and vigilance are described,and some essential issues arising from the relevance-theoretic approach to humor are reconsidered with some implications *** paper contributes to enhancing the explanatory power of relevance theory for the communication and comprehension of humor.

摘要：Dear Editor,Clustered regularly interspaced short palindromic repeats associated protein(CRISPR/Cas)systems are convenient and versatile tools for genome *** by a guide RNA(gRNA),the Cas nuclease produces double-strand break(DSB)at the target site,generally resulting in small base insertion/deletion mutations by the non-homologous end joining(NHEJ)DNA repair.

摘要：The Left Hand of Darkness （abbr. LHD） is composed by Ursula Le Guin as a ＂thought experiment＂ to explore the postgender world on the planet of Gethen. By eradication of sexual difference and embracing the biological fluidity and psychological androgeny, dualism is deconstructed, and a postgender intersubjective space is reconstructed between Genly Ai and Estraven, interluded by cyborg myth and postgenderism culture narratives. Moreover, Le Guin suggests a possible transformation mode ofyin-yang cycle from psychoanalytic light and shadow.