摘要：The coronary artery calcification score and pericardial fat volume have recently been reported to be strongly associated with the severity and presence of coronary atherosclerosis. However, no studies have explored the outcome of phased progression of atherosclerosis by non-contrast computed tomography in asymptomatic people in China. The population-based cohort study in outcome of phased progression of atherosclerosis in China （PERSUADE）, an observational, longitudinal and prospective cohort study in a target population of healthy sub- jects based in Jidong Oilfield （China）, prospectively analyzes the outcome of phased progression of atherosclerosis by non-contrast computed tomography in healthy population. The results of this study are expected to be of value for utilizing noninvasive imaging combine with tradi- tional cardiovascular risk factors to create a risk stratification and find pertinent biomarkers associated with the outcome of phased progres- sion of atherosclerosis in healthy people, thereby could help to establish a more personalized treatment of clinical practice.

摘要：Introducing chimeric antigen receptor into immune cells against malignancies has contributed to a revolutionary innovation in cancer immunotherapy. As an important type of adaptive immune cells, T cells first caught researchers' attention and became great success in chimeric antigen receptor-based immunotherapy. However, engineered T cells seem to hit their bottleneck when resistance of cancerous cells, less encouraging responses in solid tumors and unwanted toxicities to the host remain to be ***, innate immune cells get to join the race. Representatives such as natural killer cells, natural killer T cells, γδT cells and macrophages also prove to be well redirected with chimeric antigen receptors. Compared to chimeric antigen receptor engineered T cells, these engineered innate immune cells may possess multiple targeting and killing mechanisms, have the potential to crack the barrier of solid tumors and have less side effects in the host. Besides, possible universal access to cell resources and improvements in expansion and transduction techniques make these cells promising candidates with huge potential in translational medicine. Therefore, innate immune cells claim a brand-new dimension and are likely to supplement T cells greatly in the field of chimeric antigen receptor-based immunotherapy.

摘要：Objective:This study aimed to assess the perception of caring behaviors and associated factors among nurses and midwives who provided maternal health care services at Sidama region public hospitals,Hawassa,***:An institutional-based cross-sectional study design was used on a sample of 269 nurses and midwives working in maternity wards in Sidama region public hospitals.A self-administered questionnaire was used to collect *** and multivariable logistic regression analysis was used to identify factors associated with nurses’and midwives’perceptions of caring ***:Totally 261 nurses and midwives participated the *** on the mean score,participants’perception of caring behavior was classified as higher and *** to this study,75.1%(196/261)of nurses and midwives demonstrated a higher perception of caring ***’age,professional satisfaction,personal satisfaction,midwife/nurse-doctor relationship and workload were significantly associated with their perception of caring ***:Assessing the nurses’and midwives’perception of caring behavior and related factors is crucial for providing high-quality nursing and midwifery *** is suggested to create a positive and conducive caring behavior in the organization by reducing excessive workload of nurses and midwives,as well as enhancing nurse/midwife-doctor relationship,and increasing their job satisfaction by providing recognition and reward will improve nurses’and midwives’caring behavior.

摘要：Acute kidney injury(AKI),has become the focus of increasing attention due to its high risk of *** early diagnosis and treatment of AKI significantly reduce the risk of renal tissue damage and kidney ***,the efficient early diagnosis and treatment approach for AKI remains a *** screening via precise nanomaterial theranostics is a new alternative *** study summarizes the recent advances in functional nanomaterials in the early detection and treatment of *** challenges and problems in the use of nanomaterials for AKI in clinical applications are also *** is anticipated that highlighting these new advances will lay the foundation for further translational research on the promising application of nanomaterials for AKI.

摘要：In modern terminology,“organoids”refer to cells that grow in a specific three-dimensional(3D)environment in vitro,sharing similar structures with their source organs or *** themorphology or growth characteristics of organoids through a microscope is a commonly used method of organoid ***,it is difficult,time-consuming,and inaccurate to screen and analyze organoids only manually,a problem which cannot be easily solved with traditional *** intelligence(AI)technology has proven to be effective in many biological and medical research fields,especially in the analysis of single-cell or hematoxylin/eosin stained tissue *** used to analyze organoids,AI should also provide more efficient,quantitative,accurate,and fast *** this review,we will first briefly outline the application areas of organoids and then discuss the shortcomings of traditional organoid measurement and analysis ***,we will summarize the development from machine learning to deep learning and the advantages of the latter,and then describe how to utilize a convolutional neural network to solve the challenges in organoid observation and ***,we will discuss the limitations of current AI used in organoid research,as well as opportunities and future research directions.

摘要：This paper combines the theory of teams and data envelopment analysis（DEA） to design a mechanism to optimally allocate resources in public healthcare. A statutory authority and the public hospitals under its governance are interpreted as a team, the members of which seek to operate efficiently under the shared institutional constraint that public healthcare is a public good. The individual public hospital exploits DEA to maximize own-payoff, subject to the team-condition that the payoff of each other public hospital does not fall and thereby subtract from the external effects created by the public supply of healthcare. The resulting team-DEA solution, which is shown to be both an individuallyefficient and team-satisficing equilibrium and to be computable in terms of a convergent algorithm, can then be applied by the authority to determine the optimal allocation of resources in public healthcare.A case based on Chinese data is presented to illustrate the team-DEA model＇s ready operationalization and computation.

摘要：Objective The Jidong Women health Cohort Study is a prospective cohort study on female-specific characteristics and risks of chronic diseases in Chinese women and focuses on the potential association between menopause and risks of cardiovascular disease(CVD). Methods The study includes 4,179 female participants with an age of older than 18 years from Caofeidian district, Tangshan city, northern China. Baseline information on female-specific characteristics and potential cardiovascular risk factors was collected and all the participants underwent a physical examination with blood samples collected in 2013. To establish a better risk assessment tool of female CVD, updated information from questionnaire investigation, physical examinations and occurrence of outcome events will be collected through a longitudinal follow-up annually up to the year 2024. Results At baseline, Mean age of the participants was 42.3 ± 12.8 years. Reproduction occurred in 2,948 participants(70.5%), menopausal transition in 173(4.3%), and postmenopause in 1,058(25.3%). The incidence of arterial hypertension, dyslipidemia, and diabetes showed significant difference across different groups stratified by Stage of Reproductive Aging Workshop(STRAW) system(P < 0.05). Conclusion The Jidong Women health Cohort Study will contribute to the scientific evidence on association between female-specific characteristics and cardiovascular risks, and will also be helpful to provide a new path for early detection and prevention of CVD.

摘要：An investigation into the effect of several novel well-designed guanidinium salt ionic liquids（GILs） on inhibitting tumor growth is described. The GILs which have longer alkyl chain（6-18 carbon atoms） exhibit the high cytotoxicity to Hela299, B16 and SMMC-7721 cells so as to inhibit their proliferation. The inhibitory effect of the most effective GILl2 is about 10-fold higher than that of MMC（a common chemotherapy drug in clinic）.

摘要：Objectives:Many studies concerning the roles and functions of school nurses exist,however,such studies are very limited in Turkey and there is any research on a comprehensive measuring tool that can evaluate teachers'and parents'perceptions and expectations of school nurses *** purpose of this study is to develop a valid and reliable assessment tool that can be used to determine parents'and teachers'expectations of school nurse's ***:For the methodological research"Parents'and Teachers'Expectations of school Nurse's Roles"scale was designed and administered at primary and high schools in *** assess the data,assessment of item variability,internal consistency,factor analysis,correlations between the scale and subscales,and test-retest reliability were ***:The content validity index for the scale was *** a result of core components analysis varimax rotation,7 factors were obtained from 54 ***'sαcoefficient for the factors ranged from 0.82 to *** intra-class correlation coefficient for the test-retest reliability was 0.859,P<***:The scale was a rather valid and reliable assessment tool in determining the parents'and teachers'expectations of school nurses'roles.

摘要：Combination antiretroviral therapy(ART)reduced AIDS-related mortality and increased survival among patients living with HIV by interrupting HIV replication,enhancing immune recovery,and preventing the onset of opportunistic infections[1].In China,ART has rapidly been scaled up since the beginning of the National Free Antiretroviral Treatment Program(NFATP)in 2003[2].By the end of 2016,489,411 individuals diagnosed with HIV were receiving free antiretroviral treatment in *** is firmly committed to reducing overall AIDS-related mortality and HIV incidence within the ***,similar to other low-and middle-income countries,the NFATP is challenged by high mortality and attrition shortly after patients initiate ART[3].