摘要：A novel type of quinazoline derivatives,which were designed by the combination of quinazoline as the back-bone and oxazole scaffold as the substituent,have been synthesized and their biological activities were evaluated for anti-proliferative activities and EGFR inhibitory *** 12b demonstrated the most potent inhibi-tory activity(IC_(50)=0.95μmol/L for EGFR),which could be optimized as a potential EGFR inhibitor in the further *** structures of the synthesized quinazoline analogs and all intermediates were comfirmed by 1H and 13C NMR,2D NMR spectra,IR spectra and MS spectra.

摘要：As a prominent journalist and entrepreneur living in Shanghai from 1911 to 1937,the“China Hand”Carl Crow(1884-1945)wrote a lot of works on Chinese newspapers,business,religion and *** advertising agency Carl Crow,*** four editions of Newspaper Directory of China in the year of 1921,1931,1932 and 1935 respectively,and the most popular was the edition of 1935,which had a positive impact on the commercialization and development of the China’s newspaper industry.