摘要：Rapid formation of a continuous endothelial cell(EC)monolayer with healthy endothelium function on the luminal surface of vascular implants is imperative to improve the longtime patency of small-diameter vascular *** the present study,we combined the contact guidance effects of aligned nanofibers,which enhance EC adhesion and proliferation because of its similar fiber scale with native vascular basement membranes,and aligned microfibers,which could induce EC elongation effectively and allow ECs *** was followed by successive immobilization of collagen IV and laminin to fabricate a biomimetic basement membrane(BBM)with structural and compositional *** hemolysis assay and platelet adhesion results showed that the BBM exhibited excellent ***,the adhered human umbilical vein endothelial cells(HUVECs)onto theBBMaligned along the orientation of the microfibers with an elongated morphology,and the data demonstrated that the BBM showed favorable effects on EC attachment,proliferation,and *** oriented EC monolayer formed on the BBM exhibited improved antithrombotic capability as indicated by higher production of nitric oxide and prostacyclin(PGI2).Furthermore,fluorescence images indicated that HUVECs could infiltrate into the BBM,implying theBBM’s ability to enhance transmural ***,theBBMpossessed the properties to regulate ECbehaviors and allow transmural ingrowth,demonstrating the potential to be applied as the luminal surface of small-diameter vascular implants for rapid endothelialization.

摘要：本文设计合成了两种具有不同连接方式(亚胺键和sp^(2)-C-CN键)的三嗪基共价有机框架(COFs)材料.连接单元的微小变化导致可见光驱动制氢性能的巨大差异.具有sp^(2)碳连接方式的全π共轭二维COFs在450 nm波长处表现出13.48%的外量子效率,优于已报道的COFs光催化剂.而亚胺键的二维COFs几乎没有光活性.借助光电化学研究和量子化学计算进一步研究了二维COFs的催化机理,为太阳能转化高性能有机光催化剂的制备提供了新的见解.

摘要：The development of solid-state materials with switchable luminescence in response to stimuli remains a challenge,especially for organic *** crystal water significantly impacts the absorption spectra of organic crystals,it is unclear whether the emission spectra of organic luminescent materials can be systematically manipulated by *** this study,we successfully obtained curcumin monohydrate(Form X),a channel-type hydrate exhibiting crystallization-induced emission(CIE)at 608 nm(orange fluorescence),which contrasted with the conventional forms of aggregation-caused quenching(ACQ).Thermal treatment induced the release of hydration water,resulting in a new anhydrate(Form IV)that emitted yellow-green fluorescence with the emission peak at 575 ***,this approach can be used to track the absorption of curcumin crystals following subcutaneous or intramuscular *** hydratemediated single-crystal-to-single-crystal transition(SCSC)and its associated luminescence transition were reversible and responsive to temperature,offering a green approach for synthesizing and designing aggregation-induced-emission(AIE)-based intelligent luminescent devices for detecting air humidity or drug absorption.

摘要：As we navigate the transition from the Fourth to the Fifth Industrial Revolution,the emerging fields of biomanufacturing and biofabrication are transforming life sciences and *** sectors are benefiting from a synergy of synthetic and engineering biology,sustainable manufacturing,and integrated design *** techniques such as 3D bioprinting,tissue engineering,directed assembly,and self-assembly are instrumental in creating biomimetic scaffolds,tissues,organoids,medical devices,and biohybrid *** field of biofabrication in the United Kingdom and Ireland is emerging as a pivotal force in bioscience and healthcare,propelled by cutting-edge research and *** on the production of biologically functional products for use in drug delivery,in vitro models,and tissue engineering,research institutions across these regions are dedicated to innovating healthcare solutions that adhere to ethical standards while prioritising sustainability,affordability,and healthcare system benefits.

摘要：Multifunctional devices are of great interest for integration and miniaturization on the same platform, but simple addition of functionalities would lead to excessively large devices. Here, the photodetection and chemical sensing device is developed based on two-dimensional(2D) glassygraphene that meets similar property requirements for the two functionalities. An appropriate bandgap arising from the distorted lattice structure enables glassy graphene to exhibit comparable or even improved photodetection and chemical sensing capability, compared with pristine graphene. Due to strong interactions between glassy graphene and the ambient atmosphere, the devices are less sensitive to photoinduced desorption than the ones based on graphene. Consequently,the few-layer glassy graphene device delivers positive photoresponse, with a responsivity of 0.22 A W^(-1) and specific detectivity reaching ~10^(10) Jones under 405 nm ***, the intrinsic defects and strain in glassy graphene can enhance the adsorption of analytes, leading to high chemical sensing performance. Specifically, the extracted signalto-noise-ratio of the glassy graphene device for detecting acetone is 48, representing more than 50% improvement over the device based on graphene. Additionally, bias-voltage-and thickness-dependent volatile organic compound(VOC) sensing features are identified, indicating the few-layer glassy graphene is more sensitive. This study successfully demonstrates the potential of glassy graphene for integrated photodetection and chemical sensing, providing a promising solution for multifunctional applications further beyond.