摘要：As two promising biomaterials for bone implants,biomedical metals have favorable mechanical properties and good machinability but lack of bioactivity;while bioceramics are known for good biocompatibility or even bioactivity but limited by their high ***,a kind of composites composing of bioceramics and biomedical metals,have been developed as an effective solution by combining their complementary *** paper focused on the recently studied biocermets for bone implant ***,biocermets were divided into ceramic-based biocermets and metal-based biocermets according to the phase *** characteristics were systematically summarized,and the fabrication methods for biocermets were reviewed and *** were put on the interactions between bioceramics and biomedical metals,as well as the performance improvement *** importantly,the main methods for the interfacial reinforcing were summarized,and the corresponding interfacial reinforcing mechanisms were *** addition,the in vitro and in vivo biological performances of biocermets were also ***,future research directions were proposed on the advancement in component design,interfacial reinforcing and forming mechanisms for the fabrication of high-performance biocermets.

摘要：Hydroxyapatite(HA)nanoparticles and silver(Ag)nanoparticles are expected to enable desirable bioactivity and antibac-terial properties on biopolymer ***,interfacial adhesion between HA/Ag and the biopolymer is poor due to the large physicochemical differences between these *** this study,poly L-lactic acid(PLLA)powder was first surface-modified with bioactive polydopamine(PDA)in an alkaline ***,HA and Ag nanoparticles were grown in situ on the PDA-coated PLLA powder,which was then adhered to the porous bone scaffold using a selective laser-sintering *** showed that HA and Ag nanoparticles were homogenously distributed in the matrix,with enhanced mechanical *** body fluid bioactivity tests showed that the in situ grown HA-endowed scaffold shows excellent *** vitro tests confirmed that the scaffold exhibits favorable biocompatibility with human umbilical cord mesenchymal stem cells,as well as strong antibacterial activity against Gram-negative Escherichia ***,in vivo assays indicated that the scaffold promoted bone generation,with a new bone area fraction of 71.8%after 8 weeks’implantation,without inflammation.