摘要：Dermal substitutes have provided a template for the regeneration and reconstruction of the ***,the healed skin tissue often exhibits abnormal morphology and functionality,including scarring and *** this study,a composite bioink composed of methacrylated gelatin(GelMA)and chitosan oligosaccharide(COS)was proposed for printing a dermal scaffold using digital light processing(DLP)*** GelMA/COS bioink exhibited suitable porosity,swelling,degradation rate,and mechanical *** inclusion of COS demonstrated antibacterial effects against both Gram positive and Gram-negative bacteria,while simultaneously fostering the proliferation of human dermal fibroblasts(HDFs).Additionally,the application of COS could effectively reduce the expression levels of fibrosis-related genes,such as collagen I,collagen III,and fibronectin *** three-dimensionally printed cell-laden dermal scaffold exhibited excellent shape fidelity and high cellular viability,facilitating the extension of HDFs along the scaffold and the simultaneous secretion of extracellular matrix ***,the HDF-laden dermal scaffold transplanted into full-thickness skin defect sites in nude mice was shown to accelerate wound closure,reduce inflammation,and improve wound ***,the DLP-printed dermal scaffold provides an appealing approach for effectively treating full-thickness skin defects in clinical settings.

摘要：We numerically demonstrate a high-nonlinearity single-mode holey fiber with flattened dispersion around the Ti-Za laser band at 800 nm. The dispersion profile of the fiber has the shape of a quadratic curve, which reaches its maximum 5.96 ps·km^-1·nm^-1 at 800hm and its minimum -0.897 ps·km^-1·nm^-1 at both 750 and 850 nm. The nonlinear coefficient is 170 W^-1 km^-1 at 800nm and no higher order modes exit. A six-layer air-hole cladding ensures a loss less than 0.067 db/m in the 750 to 850 nm range. Two more air-hole rings will reduce the loss to below 0.1 db/km.

摘要：A novel design of nearly zero dispersion flattened photonic crystal fiber （PCF） with double cladding is proposed. To employ traditional stack and draw technology, the cladding is composed of a traditional triangular lattice of air-holes and silica. The dispersion of the fiber is mainly engineered by the small air holes in the inner cladding, which are easily preserved in the fiber drawing procedure. The large air-holes in the outer cladding are mainly for light confinement. Thus, the dispersion property of the PCF is insensitive to the deformation of the air holes in the outer cladding. Using 8 layers of air-hole ring, the loss of the fundamental mode for the PCF is as low as 0.13dB/km at 1.55μm. The dispersion of the PCF fluctuates from -0.023 to 0.021ps·km^-1nm^-1 in the range 1.45-1.625 μm.

摘要：Different types of fiber-optic sensors based on glass or polymeric fibers are used to evaluate material behavior or to monitor the integrity and long-term stability of load-bearing structure components. Fiber-optic sensors have been established as a new and innovative measurement technology in very different fields, such as material science, civil engineering, light-weight structures, geotechnical areas as well as chemical and high-voltage substations. Very often, mechanical quantities such as deformation, strain or vibration are requested. However, measurement of chemical quantities in materials and structure components, such as pH value in steel reinforced concrete members also provides information about the integrity of concrete structures. A special fiber-optic chemical sensor for monitoring the alkaline state （pH value） of the cementitious matrix in steel-reinforced concrete structures with the purpose of early detection of corrosion-initiating factors is described. The paper presents the use of several fiber-optic sensor technologies in engineering. One example concerns the use of highly resolving concrete-embeddable fiber Fabry-Perot acoustic emission （AE） sensors for the assessment of the bearing behaviour of large concrete piles in existing foundations or during and after its installation. Another example concerns fiber Bragg grating （FBG） sensors attached to anchor steels （micro piles） to measure the strain distribution in loaded soil anchors. Polymer optical fibers （POF） can be -- because of their high elasticity and high ultimate strain - well integrated into textiles to monitor their deformation behaviour. Such ＂intelligent＂ textiles are capable of monitoring displacement of soil or slopes, critical mechanical deformation in geotechnical structures （dikes, dams, and embankments） as well as in masonry structures during and after earthquakes.

摘要：For human beings of different ages and physical abilities, the inherent balance control system is ubiquitous and active to prevent falling, especially in motion states. A hybridized electromagnetic-triboelectric nanogenerator (HETNG) is prepared to harvest biomechanical energy during human balance control processes and achieve significant monitoring functions. The HETNG is composed of a symmetrical pendulum structure and a cylinder magnet rolling inside. Four coils are divided into two groups which form into two electromagnetic generators (EMGs). Besides, two spatial electrodes attached to the inner wall constitute a freestanding mode triboelectric nanogenerator (TENG). With a rectification circuit, the HETNG presents a high output power with a peak value of 0.55 W at a load of 160 Ω. Along with human balance control processes during walking, the HETNG can harvest biomechanical energy at different positions on the trunk. Moreover, the HETNG applied in artificial limb has been preliminarily simulated with the positions on thigh and foot, for monitoring the actions of squat and stand up, and lifting the leg up and down. For the elder that walks slowly with a walking aid, the HETNG equipped on the walking aid can help to record the motions of forwarding and unexpected falling, which is useful for calling for help. This work shows the potential of biomechanical energy-driven HETNG for powering portable electronics and monitoring human motions, also shows significant concerns to people lacked action capability or disabled.

摘要：Traditional tumor models do not tend to accurately simulate tumor growth in vitro or enable personalized treatment and are particularly unable to discover more beneficial targeted *** address this,this study describes the use of threedimensional(3D)bioprinting technology to construct a 3D model with human hepatocarcinoma SMMC-7721 cells(3DP-7721)by combining gelatin methacrylate(GelMA)and poly(ethylene oxide)(PEO)as two immiscible aqueous phases to form a bioink and innovatively applying fluorescent carbon quantum dots for long-term tracking of *** GelMA(10%,mass fraction)and PEO(1.6%,mass fraction)hydrogel with 3:1 volume ratio offered distinct pore-forming characteristics,satisfactorymechanical properties,and biocompatibility for the creation of the 3DP-7721 *** analysis and quantitative real-time fluorescence polymerase chain reaction(PCR)were used to evaluate the biological properties of the *** with the two-dimensional culture cell model(2D-7721)and the 3D mixed culture cell model(3DM-7721),3DP-7721 significantly improved the proliferation of cells and expression of tumor-related proteins and ***,we evaluated the differences between the three culture models and the effectiveness of antitumor drugs in the three models and discovered that the efficacy of antitumor drugs varied because of significant differences in resistance proteins and genes between the three *** addition,the comparison of tumor formation in the three models found that the cells cultured by the 3DP-7721 model had strong tumorigenicity in nude *** evaluation of the levels of biochemical indicators related to the formation of solid tumors showed that the 3DP-7721 model group exhibited pathological characteristics of malignant tumors,the generated solid tumors were similar to actual tumors,and the deterioration was *** research therefore acts as a foundation for the application of 3DP-7721 models in drug devel

摘要：采用氢气为辅助气体,在不同氢气流速下用微波等离子体辅助脉冲直流磁控溅射系统制备碳化硼薄膜。碳化硼薄膜的设计厚度为1200 nm,过渡层非晶硅的设计厚度为500 nm。所用的基板为载玻片、Ge、Si、Si wafer、GaAs和JGS3。之后,采用傅里叶红外光谱(FT-IR),X射线衍射(XRD)、维氏硬度计(Vicker indenter),分析了氢气流速(0、3、7和10 mL/min)对碳化硼薄膜的光学性质和机械性质的影响。结果表明,氢气流速的增加,可以明显提高红外光学透过率,降低红外光光吸收率。与此同时,氢气的增加还能降低薄膜应力,使薄膜易于附着在基底上。然而,氢气也会使得碳化硼薄膜硬度降低。

摘要：通过多重miRNA触发的原位siRNA递送治疗策略可以有效提高对癌细胞的精确治疗.基于DNA纳米结构的可编程性、特异性分子识别、易于功能化修饰和良好生物相容性的特点,我们设计了一个3D DNA纳米治疗平台,用于实现双miRNA触发响应的siRNA原位递送.这种3D DNA纳米结构(TY1Y2)是由DNA四面体支架、两组Y型DNA(Y1和Y2)和EpCAM核酸适体通过自组装构建而成的.TY1Y2被特异性内化至靶标癌细胞后,能够被两个内源性miRNA(miR-21和miR-122)触发,从而产生强的荧光共振能量转移信号,用于双miRNAs成像.同时,治疗性的siRNA(siSurvivin和siBcl2)也可以通过链置换反应从TY1Y2中产生并进行原位释放,实现癌细胞的协同基因治疗.这种3D DNA纳米结构将内源性生物标记物的特异性成像和治疗性基因的原位递送整合为一个多功能纳米平台,在癌症诊断和治疗方面显示出广阔的应用前景.

摘要：高铁的迅速发展为现有的高铁无线通信系统带来了一些新的挑战.一个准确描述隧道信道特性的信道模型,对高铁通信系统的设计和评估意义重大.由于隧道狭长的空间、隧道本身的边界性以及产生的波导效应等,高铁隧道中的信道特性不同于其他的高铁场景.此外,隧道信道的一些特性目前还没有被充分地研究.因此,考虑大尺度和小尺度衰落特性的准确的隧道信道模型是十分必要和重要的.本文全面地综述了已开展的隧道信道测量及采用不同方法建模的隧道信道模型,讨论了未来高铁隧道信道测量及建模的一些研究方向.