摘要：Background: Ablative skin resurfacing with carbon dioxide (CO2) and erbium:YA G lasers is still considered the gold standard for treating rhytides, photodamag e, and acne scars. However, the prolonged downtime and undesired concomitant eff ects that are involved have sent dermatologists looking for less invasive nonabl ative laser techniques to rejuvenate skin. Objective: To combine cold-air cool ing with single-pass CO2 laser skin resurfacing to generate as much benefit as possible while minimizing the spectrum of adverse effects. Study Design: The ef ficacy of single-pass CO2 laser skin resurfacing on perioral and periorbital w rinkles was examined prospectively during a 6- month follow-up period. In a s ide-by-side comparison, the influence of simultaneous cold-air cooling on concomitant effects, pain tolerance, therapeutic success, and patient satisfacti on was also studied. Eight patients with perioral and/or periorbital wrinkles un derwent the procedure. During laser treatment, only the right half of each facew as cooled using a cold-air system. Results: Six months after treatment, a mild improvement of the wrinkles was observed in all cases. The use of cold-air co oling did not have any impact on the longterm results, although in a direct comp arison between sides, it was observed that