摘要：Seven 2,6-disubstituted N-(2-phenoxy)ethyl imidazo[1,2-a]pyridine-3-carboxamide series co.taining various amine moieties were designed and synthesized as new anti-TB *** of them show excellent in vitro activity against both drug-sensitive MTB strain H37Rv and two MDR-MTB clinical isolates(MIC:<0.002-0.030 μg/mL).co.pounds 2f,5e and 5g display acceptable safety and pharmaco.inetic profiles,opening a new direction for further development.