摘要：背景:PPA(phenylpropanolam.ne,苯丙醇胺)常见于食欲抑制药和咳嗽感冒药中,以往病例报告表明含PPA的药物与出血性中风有关,通常发生在首次使用后。为阐明二者相关性,我们设计了一项病例对照研究。方法:18～49岁的男、女性研究病例来自美国43所医院,其合格标准包括在参与项目前30天内发生蛛网膜下腔出血或颅内出血,而既往并无确诊的脑损伤史。采用随机电话拨号,为每个病例安排2例对照进行面访。结果:调查人群包括702名病例和1376名对照。女性服用含PPA食欲抑制药和出血性中风危险之间相关联的调整比值比为16.58(95％可信区间1.51～182.21,P=0.02);女性首次服用含PPA药物与出血性中风危险之间关联的调整比值比3.13(95％可信区间0.86～11.46,P=0.08),所有首次服用的PPA皆为咳嗽感冒药。男、女性调查人群服用含PPA药物与出血性中风危险二者关联的调整比值比为1.49(95％可信区间0.84～2.64.P=0.17);男、女性调查人群服用含PPA的咳嗽感冒药与出血性中风危险二者关联的调整比值比为1.23(95％可信区间0.68～2.24,P=0.49),服用舍PPA的食欲抑制药与出血性中风危险关联的调整比值比为15.92(95％可信区间1.38～184.13,p=0.03)。对男性的分析结果表明:服用含PPA的咳嗽感冒药未引起出血性中风危险增加,男性无一例使用?

摘要：肿瘤药物的靶向治疗是以已知肿瘤发生中涉及的异常分子和基因为靶点而设计和研制的药物。实践证明,肿瘤靶向药物治疗为乳腺癌、肠癌、肺癌等多种恶性肿瘤的治疗提供了新的有效方法。肿瘤靶向药物分为肿瘤细胞单克隆抗体和抑制肿瘤细胞增殖的靶向药物,其中前者又包括抗肿瘤单抗药物和抗肿瘤单抗偶联物。本文对肿瘤抗体介导的靶向治疗药物的应用现状作一阐述。

摘要：This stud. was und.rtaken to evaluate knowled.e of cervical d.splasia and.hum.n papillom.virus (HPV) am.ng wom.n seen in a colposcopy clinic. Stud. d.sign. d.m.graphics, knowled.e, and.psychological d.stress were assessed.in structured.interviews with 175 wom.n before, d.ring, and.after colposcopy. Results. Respond.nts had.low knowled.e scores before and.after colposcopy; however, their overall knowled.e im.roved.slightly (P = 0.013) following the exam. When responses were exam.ned.by question, respond.nts d.m.nstrated.a significant increase of correct answers to only one question: d.es d.splasia, or precancerous cells on the cervix, always go away without treatm.nt? Pre-exam.knowled.e was positively associated.with ed.cational level and.was lower am.ng Hispanics and.patients recruited.at the clinic. Post-exam.knowled.e was positively associated.with pre-exam.knowled.e and.ed.cational level. Conclusion. Routine clinical ed.cation d.ring colposcopy can im.rove patients’ und.rstand.ng of cervical cancer; however, the low level of knowled.e that persisted.after colposcopy is a cause for concern.