摘要：探索具有深紫外相位匹配能力的新型非线性光学材料是当前研究热点.本文从硼氧阴离子框架出发,发现由π共轭BO_(3)基团组成一维(BO_(2))∞链的电子离域导致了极化特性增强,可实现非线性光学性能的优化.据此,本文预测了以(BO_(2))∞链为阴离子框架的CaBO_(2)F体系.重点研究了三种能量最低的结构CaBO_(2)F-Ⅰ,CaBO_(2)F-Ⅱ和CaBO_(2)F-Ⅲ,设计了热力学上可进行的反应路径.第一原理计算表明,CaBO_(2)F-Ⅰ,CaBO_(2)-F-Ⅱ和CaBO_(2)F-Ⅲ具有较宽的带隙,合适的双折射(0.076–0.108@1064 nm)和较大的倍频系数(2.1–2.7×KDP).其中,计算得到CaBO_(2)F-Ⅰ的最短相位匹配波长在约为195 nm(基于HSE06带隙修正剪刀算符),证明了含有定向电子离域的(BO_(2))∞链是深紫外非线性光学材料的潜在阴离子框架.本文通过将机理研究与验证性的结构预测相结合实现了自上而下设计深紫外非线性光学结构模板,该研究为探索新型非线性光学材料提供了新的策略.

摘要：Limitations of monolayer culture conditions have motivated scientists to explore new models that can recapitulate the architecture and function of human organs more *** advances in the improvement of protocols have resulted in establishing three-dimensional(3D)organ-like architectures called‘organoids’that can display the characteristics of their corresponding real organs,including morphological features,functional activities,and personalized responses to specific *** discuss different organoid-based 3D models herein,which are classified based on their original germinal *** of organoids simulating the complexity of real tissues could provide novel platforms and opportunities for generating practical knowledge along with preclinical studies,including drug screening,toxicology,and molecular pathophysiology of *** paper also outlines the key challenges,advantages,and prospects of current organoid systems.

摘要：宽带有机光电探测器(OPDs)可以集成到各种可穿戴设备中,在健康监测等领域显示出巨大的应用潜力.这里,我们以酞菁铅(PbPc)和富勒烯(C70)小分子分别作为给体和受体,基于MoO_(3)俘获电子辅助空穴隧道注入的机制实现了高性能宽带倍增型有机光电探测器(PM-OPDs).为了控制PbPc分子的晶相结构,我们分别制备了PbPc:C70体异质结(BHJ)和PbPc/C70平面异质结(PHJ)器件.可以看出,PHJ器件表现出更强的近红外吸收特性,即更有利于PbPc分子形成三斜相结构.我们进一步使用具有吸收互补特性的材料(PbPc和SubPc)作为有源层,采用PHJ/BHJ混合异质结结构,制备了在300–1000 nm范围内平坦的全色PM-OPDs.在-8 V反向偏压下,制得的全色PM-OPDs在整个光谱响应范围内的外量子效率都超过1000%.最后,我们在聚对苯二甲酸乙二醇酯基板上制备了柔性全色PM-OPDs,并成功地实现了人体脉搏信号的检测.本文通过设计器件结构和选择合适的材料,为获得高性能全色PM-OPDs提供了一种新策略.

摘要：Multicellular microtissues of primary human hepatocytes(PHHs)co-cultured with other supporting cell types are a promis-ing model for drug screening and toxicological ***,these liver microtissues(LMs)rapidly lose their functions during ex vivo ***,in order to mimic the cellular and structural hepatic microenvironment,we co-cultured PHHs with human mesenchymal stromal cells(MSCs)and human umbilical vein endothelial cells(HUVECs)in the presence of cell-sized microparticles(MPs)derived from liver extracellular matrix(LEMPs).The microwell culture platform enabled biofabrication of size-controlled multicellular microtissues(PHH:HUVEC:MSC=3:2:1)with efficient LEMP incorporation(about 70%at a 2:1 ratio of cells:MP).The biofabricated liver microtissues(BLMs)were cultured ex vivo for 14 days and compared to the cell-only LM in terms of gene and protein expression,functional activity,cytochrome P450(CYP450)enzyme inducibility,and drug *** results supported superior hepatic-related gene expression,functional activity,and polarity for PHH in BLM compared to ***450 enzyme inducibility and dose-responsive sensitivity to toxic drugs were significantly higher in the BLM *** conclusion,microtissue engineering by incorporation of tissue-specific microparticles within a multicellular microtissue can offer some advantages for drug discovery studies and cell transplantation *** the near future,this approach could generate a scalable platform of several functional biofabricated microtissues representing different organs.