摘要：Background:Handan eye Study (HES),a large population-based cohort study in rural area of northern China,was one of the few studies focusing on the major eye diseases of rural Chinese *** aim of this study was to introduce the design,methodology and to assess the data quality of the follow-up phase of ***:All participants were recruited in Yongnian county of Handan city between 2012 and *** outcomes were measured by visual quality scales and ocular *** performed the Chi-square test to make comparison of categorical data among groups,One-way analysis of variance and Kruskal-Wallis test was applied to make comparison of continuous data among groups,a post-hoc test was done to make further pairwise ***-class correlation coefficients (ICCs) and Kappa coefficients were used to evaluate the consistency between different *** regression was used to explore the influence factors of death,odds ratio (OR) and 95% confidence interval (CI) were used to estimate the effect size of each influence ***:The follow-up rate was 85.3%.Subjects were classified into three groups:the follow-up group (n =5394),the loss to follow-up group (n =929),and the dead group (n =507),comparison of their baseline information was *** with the other two groups,age of the dead group (66.52 ± 10.31 years) was the oldest (Z =651.293,P < 0.001),male proportion was the highest (59.0 %)(x2 =42.351,P < 0.001),only 65.9 % of the dead finished middle school education (Z =205.354,P < 0.001).The marriage percentage,body mass index (BMI),best-corrected visual acuity (BCVA),and intra-ocular pressure of the dead group was the lowest *** equivalent error (SER) of the dead group was the ***,history of smoking,hypertension,diabetes,and heart disease were more common in the dead *** analysis showed that age (OR =1.901,95% CI:1.074-1.108),gender (OR =0.317,95% CI:0.224-0.448),and BCVA (OR =0.282,95%