摘要：Ensuring a sufficient oxygen supply is pivotal for the success of bioprinting applications since it fosters tissue integration and natural *** in oxygen concentration among diverse tissues necessitates the precise recreation of tissue-specific oxygen levels in imprinted constructs to support the survival of targeted *** oxygen-releasing biomaterials,such as oxygen-generating microparticles(OMPs),have shown promise for enhancing the oxygen supply of microenvironments in injured tissues,whether this approach is scalable for large tissues and whether tissue-specific bioinks with varying OMP concentrations remain printable remain *** study addresses this critical gap by introducing an innovative class of engineered oxygenated bioinks that combine colloidal-based microgels with *** report that incorporating nanosized calcium peroxide(nCaO_(2))and manganese oxide nanosheets(nMnO_(2))into hydrophobic polymeric microparticles enables precise modulation of oxygen release while controlling hydrogen peroxide ***,the fabrication of oxygenating and cytocompatible colloidal gels is achieved using an aqueous two-phase *** study thoroughly evaluates the fundamental characteristics of the resulting bioink,including its rheological behaviors,printability,shape fidelity,mechanical properties,and oxygen release ***,this study demonstrates the macroscopic scalability and cytocompatibility of printed constructs produced via cell-laden oxygenating colloidal *** showcasing the effectiveness of extrusion-based bioprinting,this study underscores how it can be used to fabricate biomimetic tissues,indicating its potential for new *** findings presented here advance the bioprinting field by achieving scalability with both high cell viability and the possibility of mimicking specifically oxygenated *** work thereby offers a promising avenue for the development of functional tissues with e

摘要：Oxygen(O_(2))-sensing matrices are promising tools for the live monitoring of extracellular O_(2) consumption levels in long-term cell *** this study,ratiometric O_(2)-sensing membranes were prepared by electrospinning,an easy,low-cost,scalable,and robust method for fabricating ***(ε-caprolactone)and poly(dimethyl)siloxane polymers were blended with tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II)dichloride,which was used as the O_(2)-sensing probe,and rhodamine B isothiocyanate,which was used as the reference *** functionalized scaffolds were morphologically characterized by scanning electron microscopy,and their physicochemical profiles were obtained by Fourier transform infrared spectroscopy,thermogravimetric analysis,and water contact angle *** sensing capabilities were investigated by confocal laser scanning microscopy,performing photobleaching,reversibility,and calibration curve studies toward different dissolved O_(2)(DO)*** sensing nanofibers showed a high response to changes in DO concentrations in the physiological-pathological range from 0.5%to 20%and good stability under ratiometric *** addition,the sensing systems were highly biocompatible for cell growth promoting adhesiveness and growth of three cancer cell lines,namely metastatic melanoma cell line SK-MEL2,breast cancer cell line MCF-7,and pancreatic ductal adenocarcinoma cell line Panc-1,thus recreating a suitable biological environment in *** O_(2)-sensing biomaterials can potentially measure alterations in cell metabolism caused by changes in ambient O_(2)content during drug testing/validation and tissue regeneration processes.

摘要：随着废水零排放的标准与要求不断深化,高效可持续的膜分离水处理技术成为研究热点,但面临着水通量低、易污染等问题。本研究通过石墨相氮化碳(g-C_(3)N_(4))、细菌纤维素(BC)和硫化铋(Bi_(2)S_(3))三者的有机结合,经真空辅助抽滤法制备得到光催化自清洁复合膜。通过一系列表征手段对粉末及膜材料进行物相结构与元素能态分析,研究了g-C_(3)N_(4)和Bi_(2)S_(3)不同添加量对复合膜染料分离性能的影响规律,探讨了两者在光催化下对染料的降解机制。结果表明,60wt%的g-C_(3)N_(4)、10wt%的BC、30wt%的Bi_(2)S_(3)与复合膜的综合性能最佳,水通量和截留率分别为23.48 L·m^(−2)·h^(−1)和100%,长时间过滤中依然保持16.65 L·m^(−2)·h^(−1)的水通量和90%左右的染料截留,在光照下浸泡3 h后通量恢复率达到96.5%,表明了该膜具有良好的光催化自清洁性能。该研究为高通量、可持续分离膜的设计提供了新的思路及基础探索。

摘要：Three-dimensional(3D)printing has attracted increasing research interest as an emerging manufacturing technology for devel-oping sophisticated and exquisite architecture through hierarchical *** has also been employed in various advanced industrial *** development of intelligent biomedical engineering has raised the requirements for 3D printing,such as flexible manufacturing processes and technologies,biocompatible constituents,and alternative ***,state-of-the-art 3D printing mainly involves inorganics or polymers and generally focuses on traditional industrial fields,thus severely limiting applications demanding biocompatibility and *** this regard,peptide architectonics,which are self-assembled by programmed amino acid sequences that can be flexibly functionalized,have shown promising potential as bioinspired inks for 3D ***,the combination of 3D printing and peptide self-assembly poten-tially opens up an alternative avenue of 3D bioprinting for diverse advanced ***,a small but innovative nation,has significantly contributed to 3D bioprinting in terms of scientific studies,marketization,and peptide architectonics,including modulations and applications,and ranks as a leading area in the 3D bioprinting *** review summarizes the recent progress in 3D bioprinting in Israel,focusing on scientific studies on printable components,soft devices,and tissue *** paper further delves into the manufacture of industrial products,such as artificial meats and bioinspired supramolecular architectures,and the mechanisms,physicochemical properties,and applications of peptide ***,Israel contributes significantly to the field of 3D bioprinting and should thus be appropriately recognized.

摘要：Commercially pure titanium and titanium alloys have been among the most commonly used materials for biomedical applications since the 1950 *** to the excellent mechanical tribological properties,corrosion resistance,biocompatibility,and antibacterial properties of titanium,it is getting much attention as a biomaterial for ***,titanium promotes osseointegration without any additional adhesives by physically bonding with the living bone at the implant *** properties are crucial for producing high-strength metallic alloys for biomedical *** alloys are manufactured into the three types ofα,β,andα+β.The scientific and clinical understanding of titanium and its potential applications,especially in the biomedical field,are still in the early *** review aims to establish a credible platform for the current and future roles of titanium in *** first explore the developmental history of ***,we review the recent advancement of the utility of titanium in diverse biomedical areas,its functional properties,mechanisms of biocompatibility,host tissue responses,and various relevant antimicrobial *** research will be directed toward advanced manufacturing technologies,such as powder-based additive manufacturing,electron beam melting and laser melting deposition,as well as analyzing the effects of alloying elements on the biocompatibility,corrosion resistance,and mechanical properties of ***,the role of titania nanotubes in regenerative medicine and nanomedicine applications,such as localized drug delivery system,immunomodulatory agents,antibacterial agents,and hemocompatibility,is investigated,and the paper concludes with the future outlook of titanium alloys as biomaterials.

摘要：Significant advancements in various research and technological fields have contributed to remarkable findings on the physiological dynamics of the human *** closely mimic the complex physiological environment,research has moved from two-dimensional(2D)culture systems to more sophisticated three-dimensional(3D)dynamic *** bioreactors or microfluidic-based culture models,cells are typically seeded on polymeric substrates or incorporated into 3D constructs which are mechanically stimulated to investigate cell response to mechanical stresses,such as tensile or *** review focuses on the working principles of mechanical stimulation devices currently available on the market or custom-built by research groups or protected by patents and highlights the main features still open to *** are the features which could be focused on to perform,in the future,more reliable and accurate mechanobiology studies.

摘要：As a bone scaffold,meeting all basic requirements besides dealing with other bone-related issues-bone cancer and accelerated regeneration-is not expected from traditional scaffolds,but a newer class of scaffolds called *** a clinical point of view,being a multifunctional scaffold means reducing in healing time,direct costs-medicine,surgery,and hospitalization-and indirect costs-loss of mobility,losing job,and *** main aim of the present review is following the multifunctional bone scaffolds trend to deal with both bone regeneration and cancer *** consideration is given to different fabrication techniques which have been applied to yield these materials spanning from traditional to modern ***,the hierarchical structure of bone plus bone cancers and available medicines to them are introduced to familiarize the potential reader of review with the pluri-disciplinary essence of the ***,a brief discussion relating to the future trend of these materials is provided.

摘要：Of late, the relevance of silk in a myriad of material science and biotechnological realms has been realized, as attested by the incessantly clambering number of reports and patents in the scienti fic repositories. The write-up is geared off with a scrutiny into the pertinence of the basic nano-structural features of silk, christened as the ‘queen of textile’ for exemplary bioengi- neering applications including designing and fabrication of devices for micro fluidics, opto fluidics, chemo/bio sensing, etc. Then, the major thrust of this short review is directed towards comprehending the prospects of using silk-based biomaterials (e.g. sca ffolds, electrospun membranes, films, hydrogels, bioinks) for tissue engineering and regenerative medicine as well as targeted delivery of various biomolecular cargoes/therapeutic agents, etc., as vouched by few avant-garde endeavours of the recent years. The write-up is entwined with a discussion on the various factors that could plausibly hinder the realization of silk as the next-generation nanobiomaterial, suggestions for some approaches to dodge and deal with the practical snags and what lies ahead!

摘要：具有高比表面积及规则孔道结构的离子型共价有机框架(COF)材料表现出广泛的应用前景.本文设计合成了一种基于联吡啶嗡盐的阳离子型COF材料(PS-COF-1).PS-COF-1比表面积为2703 m^(2) g^(-1),高于目前报道的其他离子型COF材料.PS-COF-1具有固定的一维通道(~4.5 nm)、良好的化学稳定性和耐辐照稳定性,表现出优异的吸附ReO_(4)^(-)(最大吸附量为1262 mg g^(-1))和^(99)TcO_(4)^(-)性能.进一步研究表明,PS-COF-1在高离子强度下表现出快速吸附动力学、高吸附容量和对^(99)TcO_(4)^(-)和ReO_(4)^(-)的高选择性,在模拟美国汉福德低活性废物流条件下成功选择性去除了^(99)TcO_(4)^(-).此外,PS-COF-1能够在10 min内将ReO_(4)^(-)和^(99)TcO_(4)^(-)污染水净化至饮用水级别.密度泛函理论计算表明,PS-COF-1对低电荷密度阴离子ReO_(4)^(-)和^(99)TcO_(4)^(-)具有强的亲和力(优于其他常见阴离子,如Cl^(-),NO_(3)^(-),SO_(4)^(2-),CO_(3)^(2-)),阐明了PS-COF-选择性吸附^(99)TcO_(4)^(-)的机理.本文展示了一种用于选择性捕获放射性核素新型阳离子COF吸附剂,为放射性污染治理提供了重要的理论依据和指导.

摘要：The development of natural biomaterials applied for hard tissue repair and regeneration is of great importance,especially in societies with a large elderly ***-assembled peptide hydrogels are a new generation of biomaterials that provide excellent biocompatibility,tunable mechanical stability,injectability,trigger capability,lack of immunogenic reactions,and the ability to load cells and active pharmaceutical agents for tissue ***-based hydrogels are ideal templates for the deposition of hydroxyapatite crystals,which can mimic the extracellular ***,peptide-based hydrogels enhance hard tissue repair and regeneration compared to conventional *** review presents three major self-assembled peptide hydrogels with potential application for bone and dental tissue regeneration,including ionic self-complementary peptides,amphiphilic(surfactant-like)peptides,and triple-helix(collagen-like)*** attention is given to the main bioactive peptides,the role and importance of self-assembled peptide hydrogels,and a brief overview on molecular simulation of self-assembled peptide hydrogels applied for bone and dental tissue engineering and regeneration.