摘要：In this paper,the authors analyze the stability of a class of interconnected systems withsubsystem unmodeled dynamics and dynamic interactions employing decentralized adaptive controllersdesigned by Wen,Zhou,and Wang (2008) in the presence of actuator *** will be shown that theglobal stability of the remaining closed-loop system is still ensured and the outputs are also regulatedto zero when some subsystems break down.

摘要：纤维技术领域的最新突破促使具有紧密界面的功能材料能够在一维限域空间内精准组装成具有特定几何结构的单根纤维,可用于传感器、能量收集和存储、显示器和医疗设备等.其中,半导体是调节纤维器件性能的关键组件,因此,纤维内部半导体的选择.

摘要：Additive manufacturing(AM)has revolutionized the design and manufacturing of patient-specific,three-dimensional(3D),complex porous structures known as scaffolds for tissue engineering *** use of advanced image acquisition techniques,image processing,and computer-aided design methods has enabled the precise design and additive manufacturing of anatomically correct and patient-specific implants and ***,these sophisticated techniques can be timeconsuming,labor-intensive,and ***,the necessary imaging and manufacturing equipment may not be readily available when urgent treatment is needed for trauma *** this study,a novel design and AM methods are proposed for the development of modular and customizable scaffold blocks that can be adapted to fit the bone defect area of a *** modular scaffold blocks can be combined to quickly form any patient-specific scaffold directly from two-dimensional(2D)medical images when the surgeon lacks access to a 3D printer or cannot wait for lengthy 3D imaging,modeling,and 3D printing during *** proposed method begins with developing a bone surface-modeling algorithm that reconstructs a model of the patient’s bone from 2D medical image measurements without the need for expensive 3D medical imaging or *** algorithm can generate both patient-specific and average bone ***,a biomimetic continuous path planning method is developed for the additive manufacturing of scaffolds,allowing porous scaffold blocks with the desired biomechanical properties to be manufactured directly from 2D data or *** algorithms are implemented,and the designed scaffold blocks are 3D printed using an extrusion-based AM *** and instructions are also provided to assist surgeons in assembling scaffold blocks for the self-repair of patient-specific large bone defects.

摘要：具有生物力学和生化活性的敷料在伤口护理和皮肤组织再生中起着至关重要的作用.然而,机械失配和药物释放管理所涉及的问题限制了当前敷料的有效使用.在本工作中,我们报道了一种简单的策略,即采用聚偏二氟乙烯(PVDF)作为底物,通过嵌入不同尺寸的沸石咪唑酸盐框架(ZIF-8)种子,以推动具有均匀蜂窝结构的高柔性金属有机框架(MOF)复合膜的受控生长,用于药物负载和释放.以嵌入的种子为控制中心,形成的多孔膜具有约0.7-3μm的宽孔隙.这种可调节的微尺度孔与ZIF-8中的固有纳米孔不仅可以有效地提高抗炎类药物的负载(姜黄素,CCM),而且还能够快速并可控地释放药物,大大提高了抗菌活性,同时促进细胞生长.其中,在40 nm种子上生长的0.7μm多孔膜的表现优于其他蜂窝膜,与2μm多孔膜(相当于裸PVDF基质)相比,细胞增殖能力提高了约2倍,针对金黄色葡萄球菌(***)和大肠杆菌(***)的抗菌活性分别提高了5倍和2.4倍,是基底抗菌活性的5倍,这是因为这种最佳孔几何结构具有CCM和Zn2+释放特性的平衡效应.这种可控分层孔阵列膜的独特性质有望真正用于伤口愈合,同时也为生物医学设计提供了新的指导.

摘要：Among the different bioprinting techniques,the drop-on-demand(DOD)jetting-based bioprinting approach facilitates contactless deposition of pico/nanoliter droplets ofmaterials and cells for optimal cell–matrix and cell–cell *** bioinks play a critical role in the bioprinting process,there is a poor understanding of the influence of bioink properties on printing performance(such as filament elongation,formation of satellite droplets,and droplet splashing)and cell health(cell viability and proliferation)during the DOD jetting-based bioprinting *** inert polyvinylpyrrolidone(PVP360,molecular weight=360 kDa)polymerwas used in this study to manipulate the physical properties of the bioinks and investigate the influence of bioink properties on printing performance and cell *** experimental results showed that a higher bioink viscoelasticity helps to stabilize droplet filaments before rupturing from the nozzle *** highly stretched droplet filament resulted in the formation of highly aligned“satellite droplets,”which minimized the displacement of the satellite droplets away from the predefined ***,a significant increase in the bioink viscosity facilitated droplet deposition on the wetted substrate surface in the absence of splashing and significantly improved the accuracy of the deposited main *** analysis showed that cell-laden bioinks with higher viscosity exhibited higher measured average cell viability(%),as the presence of polymer within the printed droplets provides an additional cushioning effect(higher energy dissipation)for the encapsulated cells during droplet impact on the substrate surface,improves the measured average cell viability even at higher droplet impact velocity and retains the proliferation capability of the printed *** the influence of bioink properties(e.g.,bioink viscoelasticity and viscosity)on printing performance and cell proliferation is important for the formulation

摘要：Bone cancer is a critical health problem on a global scale,and the associated huge clinical and economic burdens are still *** many clinical approaches are currently used for bone cancer treatment,these methods usually affect the normal body functions and thus present significant ***,advanced materials and additive manufacturing have opened up promising avenues for the development of new strategies targeting both bone cancer treatment and post-treatment bone *** paper presents a comprehensive review of bone cancer and its current treatment methods,particularly focusing on a number of advanced strategies such as scaffolds based on advanced functional materials,drug-loaded scaffolds,and scaffolds for photothermal/magnetothermal ***,the main research challenges and future perspectives are elaborated.

摘要：由于机器学习智力和能力有限,它目前仍无法处理各种情况,因此不能在现实应用中完全取代人类。因为人类在复杂场景中表现出稳健性和适应性,所以将人类引入人工智能(AI)的训练循环并利用人类智慧进一步提升机器学习算法变得至关重要。本研究开发了一种基于实时人工指导(Hug)的深度强化学习(DRL)方法,用于端到端自动驾驶案例中的策略训练。通过新设计的人类与自动化之间的控制转移机制,人类能够在模型训练过程中实时干预和纠正智能体的不合理行为。基于这种人机回环的指导机制,本研究开发一种基于修正策略和价值网络的改良的动作-评价架构(actor-critic architecture)。所提出的Hug-DRL的快速收敛允许实时的人工指导行为融合到智能体的训练循环中,进一步提高了DRL的效率和性能。本研究通过40名受试者的人机回环实验对开发的方法进行了验证,并与其他最先进的学习方法进行了比较。结果表明,该方法可以在人工指导下有效地提高DRL算法的训练效率和性能,且对参与者的专业知识或经验没有硬性要求。

摘要：Solar-driven catalysis represents a promising strategy and an important approach to provide clean energy and renewable *** decades of research on solar-driven catalysis,scientists are now focusing on module design,mechanistic study,and practical application along with catalyst design[1–6].In the

摘要：A nonmetal transportation port with soft soil foundation of Tianjin New Harbor failed during construction in 1997. The soil properties and geological changes before and after landslide were in- vestigated by in situ test means. The stability of the slope was estimated with several calculation methods, such as the simplified Bishop method and the non-circle analysis method. According to the investigation and analysis results, the factors that may cause the slope failure can be deter- mined as follows: excessive excavating, violating the normal construction procedure, excessive pore water pressure during earlier piling and sudden water-level fluctuation in front of the slope. Measures to improve the soil foundation for reconstructing the port include strengthening the failed slope with vibro sand piles, filling up the crushed stone layer, dividing the excavation into four steps and driving piles by larger intervals. The port now has been successfully reconstructed and begun operation.

摘要：A growing number of three-dimensional(3D)-print- ing processes have been applied to tissue engineering. This paper presents a state-of-the-art study of 3D-printing technologies for tissue-engineering applications, with particular focus on the development of a computer-aided scaffold design system; the direct 3D printing of functionally graded scaffolds; the modeling of selective laser sintering(SLS) and fused deposition modeling(FDM) processes; the indirect additive manufacturing of scaffolds, with both micro and macro features; the development of a bioreactor; and 3D/4D bioprinting. technological limitations will be discussed so as to highlight the possibility of future improvements for new 3D-printing methodologies for tissue engineering.