摘要：Functionalized hydrogels stimulate the migration and morphogenesis of endothelial cells(ECs)and are useful substrates for wound *** present study investigates the feasibility of covalent conjugation of taurine(Tau)on a gelatin-based *** hydrogel is expected to maintain positive charged growth factors such as basic fibroblast growth factor(bFGF)and vascular endothelial growth factors(VEGFs)near ECs within the hydrogel *** gelatin was conjugated with hydroxyl phenol(Ph)and Tau moieties,and in following that Ph residues were crosslinked through a horseradish peroxidase-catalyzed *** migration characteristics of ECs were analyzed by scratch migration assay and microparticle-based cell migration *** morphology and amounts of angiopoietin 1(Ang 1),bFGF,and VEGF proteins were evaluated for encapsulated *** potential of synthesized hydrogels in wound healing was assessed by the percentage of reduction from the original wound size and histopathological analyses of rat *** incorporated Tau molecules within the hydrogel remained stable through covalent bonds during *** extended incubation,the gelatin-based hydrogel conjugated with Tau improved the migration distance and number of existing migrated *** Tau within the gelatin-based hydrogel induced high motility of ECs,accompanied by robust cytoskeleton extension and a cell subpopulation that expressed CD44 and CD31 receptors as well as enhancement of Ang 1,bFGF,and *** found that injectable Gel-Ph-Tau effectively improves wound-healing parameters.

摘要：针对铝合金钨极惰性气体保护电弧焊(tungsten inert gas arc welding,TIG焊)过程中,焊接工艺参数的实时状态与焊缝熔池三维尺寸间的非线性对应关系,研究建立一种基于信息物理融合的多传感器TIG焊过程熔池状态协同感知计算方法.首先,构建由红外温度传感器、电弧形态传感器、电弧能量传感器和焊接位置传感器组成的TIG焊过程熔池状态信息物理融合系统架构.其次,考虑焊接过程中焊枪电弧的运动特性和测量噪声影响,设计基于温度、位置、能量传感器信息交互的熔池长宽深三维参数状态感知策略,并基于多传感器数据的异步和异构特性,提出了基于无迹卡尔曼滤波的焊接过程中熔池状态的多传感器数据协同感知算法.针对7075超硬铝合金TIG焊过程进行熔池参数在线测量与辨识试验,结果表明,所提算法能够根据TIG焊过程多传感器数据实时计算熔池参数结果,焊缝宽度和焊缝高度计算结果误差基本上控制在10%以内,该算法响应时间基本控制在0.3 s内,能够较为准确地评估焊接过程中熔池的实时状态.

摘要："早期成长与发展研究"(EGDS)是一个前瞻性的养子女研究计划。此项目包括了360组相连的生身父母、养父母以及刚出生就被收养的子女。此项目从婴儿3个月就开始跟踪这些被试,现在又加上200组被试,从遗传与环境的关联与互动着手,本项目将研究家庭环境和养育方式如何影响遗传因素的表达。所有被试均需要是在美国国内收养的婴儿。该研究收集了儿童的心理特征、生身父母与养父母的心理特征、养育方式、父母的生活状况等数据,以及唾液和DNA,初步分析发现,遗传与环境的互动在婴儿期就已经开始。本文也从干预的角度讨论了未来行为遗传学的走向。

摘要：An optimized formulation of a sustained release tablet of Gliclazide was developed. The use of Doptimal design with a polynomial statistical model to analyze dissolution data reduced the number of laboratory tests required to obtain an optimal dosage form. The final formulation contained 22 mg of Methocel&regE15LV, 16.5 mg Methocel&regE15 and 10.0 mg of Dibasic Calcium Phosphate per 30 mg Gliclazide sustained release tablet. Dissolution studies performed on tablets from 5000 tablet test batches released greater than 90 percent of loaded drug in eight hours. Drug release from the optimized tablets followed a pattern more closely similar to zero-order than other mechanisms of drug release tested. Storage of tablets in accelerated and ambient conditions for 6 and 12 months respectively did not alter any of the physico-chemical properties, drug release or the drug release rate compared to initial observations and dissolution data of the prepared tablets. The addition of potassium phosphate and monosodium phosphate to the tablet reduced the effect pH has on Gliclazide dissolution compared to the commercially available product.

摘要：目的:以符合身体活动规范(MPAR)的中国留学生为研究对象,调查促进青年体育活动(YPAP)的影响因素。方法:649名中国留学生(女性320名,男性329名)参加此项研究。研究于2011年6-8月在美国进行。对参与者进行网络调查,内容包括人口统计学项目、身体活动、诱发因素、促进因素和强化因素。结果:嵌套回归分析显示在中国留学生中,如果体质指数、能力感、自信心、学习态度和欢愉度这几项指标高,加上性别指数为男,则其MPAR几率相应较高(p<0.001)。除语言障碍外,所有促进和强化因素均可通过诱发因素间接预测MPAR(p<0.001)。结论:了解中国留学生参加体育活动的影响因素,对促进他们的长期健康和幸福十分重要。若能设计出方案解决这些已被确定的关键因素,将具有现实指导意义。

摘要：介绍目前，在克拉马斯福尔斯（美国）地区的一些浅层水井中已安装了400多个钻孔换热器。主要用于提取地热能量。尽管在这些浅层水井中安装了许多钻孔换热器。以及确定了地换热器中的流体流量。但到目前为止，还没有确定地热换热器最佳的设计方案。图1所示为目前在克拇马斯福尔斯（美国）地区使用的典型钻孔换热器系统（用于从浅层、低温地热能源提取地热能量）。

摘要：Sustainable development contributes to the economic and social advancement of construction projects. Ignoring sustainability during the cost estimating process associated with evaluation phase develops many problems of conventional decision methodology used in construction industry in the most of developing countries. This research focuses on sustainability which is the key factor in all decision making in design and construction processes. Therefore, Iraqi construction industry should respond to sustainability as a leading indicator of its infrastructure rebuilding. The construction management and sustainability could help to manage the rebuilding of the destroyed public infrastructure during the disaster wars periods passed thru thirty years ago and also to modernize of private buildings and plants. Field study has been carried out by adopting personal interviews and questionnaires conducted with experts, experienced consultants and designers working in many design organizations. The data collected has been analyzed and the results obtained show a clear weakness in the field of sustainability understanding, practicing and implementation. Moreover, the design work in Iraq is suffering from a lack of scientific techniques and a lack in experience in the domain of sustainability field. This will take an integrated approach to study the impact of sustainability on construction management which encompasses both public and private sector perspectives for building and engineering construction, and the roles played by all the participants in the construction team (owners, contractors, design professionals, and other supporting professionals).

摘要：阶段变化模型于1998年首次引入我国,至今尚没有对基于该模型的身体活动研究成果进行过系统综述。对1998—2012年间,我国以此模型为基础进行的身体活动研究进行了综述;并论证了基于该模型,制订促进青少年每天锻炼一小时干预策略的可行性。在对知网等数据库的期刊论文进行计算机检索,并对符合检索条件论文的全文和参考文献进行人工检索后,114篇论文进入综述。论文被编码、分类,并使用半定量方法进行了分析。结果显示:阶段变化模型虽是我国锻炼心理学领域内备受关注的理论模型之一,但前期基于整体模型的研究和干预(或纵向)研究较少,模型在我国的适用性和应用性仍有待进一步检验。12项涉及青少年身体活动的研究中,基于整体模型的研究和干预研究各占不到一成,为后续研究提供的可参考结果极其有限。与青少年身体活动具有稳定关系的因素是性别、年级(年龄)和均衡决策。后续应考虑关注纵向设计、检验测量工具、针对不同性质被试以及基于整体模型进行研究;研究需明确界定身体活动和变化阶段的划分标准。基于阶段变化模型制定促进青少年参与体育锻炼干预策略的证据有限。

摘要：For decades,plants have been the subject of genetic engineering to synthesize novel,value-added ***(PHAs),a large class of biodegradable biopolymers naturally synthesized in eubacteria,are among the novel products that have been introduced to make use of plant acetyl-CoA metabolic *** was hoped that renewable PHA production would help address environmental issues associated with the accumulation of nondegradable plastic ***,after three decades of effort synthesizing PHAs,and in particular the simplest form polyhydroxybutyrate(PHB),and seeking to improve their production in plants,it has proven very difficult to reach a commercially profitable rate in a normally growing *** seems to be due to the growth defects associated with PHA production and accumulation in plant ***,we review major breakthroughs that have been made in plant-based PHA synthesis using traditional genetic engineering approaches and discuss challenges that have been ***,from the point of view of plant synthetic biology,we provide perspectives on reprograming plant acetyl-CoA pathways for PHA production,with the goal of maximizing PHA yield while minimizing growth ***,we suggest genetic elements that can be considered in genetic circuit design,approaches for nuclear genome and plastome modification,and the use of multiomics and mathematical modeling in understanding and restructuring plant metabolic pathways.