摘要：AIM： To compare clinical results between toric and spherical periphery design orthokeratology（ortho-k） in myopic children with moderate-to-high corneal astigmatism. METHODS： This retrospective study enrolled 62 eyes of 62 subjects using toric ortho-k lenses. These subjects were assigned to the toric group. Based on the one-to-one match principle（same age, proximate spherical equivalence and corneal astigmatism）, 62 eyes of 62 subjects were enrolled and included in the spherical group. At one-year followup visit, visual acuity, corneal astigmatism, treatment zone decentration, axial elongation and adverse reaction were compared between these two groups. RESULTS： At the one-year visit, corneal astigmatism was significantly lower in the toric group（1.22±0.76 D） than in the spherical group（2.05±0.85 D）（P=0.012）. The mean magnitude of the treatment zone decentration was 0.62±0.42 mm in the toric group and 1.07±0.40 mm in the spherical group（P=0.004）. Axial elongation was significantly slower in the toric group（0.04±0.13 mm） than in the spherical group（0.09±0.13 mm）（P=0.001）. The oneyear axial elongation was significantly correlated with initial age（r=-0.487, P〈0.001） and periphery design of ortho-k lens（r=0.315, P〈0.001）. The incidence of corneal staining was lower in the toric group（8.1%） than in the spherical group（19.4%）（P〈0.001）. CONCLUSION： Toric periphery design ortho-k lenses may provide lower corneal astigmatism, better centration, slower axial elongation and lower incidence of corneal staining in myopic children with moderate-to-high corneal astigmatism.

摘要：Purpose:To summarize the design and methodology of a multi-center *** the existed ethnic differences of glaucoma,this survey will explore the differences with regard to anterior and posterior ocular segment parameters between Caucasians and ***:In this study,four cohorts including American Caucasians and American Chinese from San Francisco,southern mainland Chinese from Guangzhou,and northern mainland Chinese from Beijing were prospectively enrolled for a series of eye examinations and tests from May 2008 to December 2010.A total of 120 subjects including 15 of each gender in each age decade from 40s to 70s were recruited for each *** of the following tests were collected:a questionnaire eliciting systemic and ocular disease history,blood pressure,presenting and best corrected visual acuity,auto-refraction,Goldmann applanation tonometry,go nioscopy,A-scan,anterior segment optical coherence tomography (ASOCT),ultrasound biomicroscopy (UBM),visual field (VF),Heidel berg retinal tomography (HRT),OCT for optic nerve,and digital fundus ***:this study will provide insights to the etiologies of glaucoma especially PACG through inter-ethnic comparisons of relevant ocular anatomic and functional parameters.

摘要：目的:全麻中两种以上的药物合并应用比单一麻醉剂更为有效。本研究是为确定中国成年患者全麻期间合并应用七氟醚与瑞芬太尼时药物相互作用的方式,并以反应曲面模型法对其进行表述。方法:1.试验设计:研究采用平行实验设计,65例病人(ASAI级,各项指标正常,无长期服用阿片类药物史)入选本次试验,随机选定并维持一定的呼末七氟醚浓度[≤2MAC(0.3 %-3.4 %)] ,逐渐增加靶控输注的瑞芬太尼浓度(≤10 ng/mL) ,观察不同浓度组合时患者对喉镜置入刺激的反应以确定麻醉是否完全。2.反应曲面模型法进行药物动力学/药效动力学分析:两药合用的效果通过对喉镜置入时的反应进行评估,0和1分别代表有或没有体动反应。以下面的药效学模型表述体动反应消失的概率(P)其中Us ,Ur分别为标准化的七氟醚与瑞芬太尼水平;U50为达最大效应一半时的药物综合标准化水平;r为形状因子;I(Q)为药物相互作用的强度函数。模型通过作图、目标函数改变以及参数的生理/临床学的合理性等几方面进行评价。P=[U50/I((QU)s]+r+U(r)Urs+Ur)r结果与结论:研究表明瑞芬太尼与七氟醚合用时为协同式相互作用,上述反应曲面模型与实际观测值有较好的拟合。应用NONMEM得到喉镜置入刺激时的参数(RSE%)为U50=6.62(10.6) ,C50 ,sevo=1.71 %(12.9) ,C50 ,remi=12.4 ng/mL(19.0) ,Imax=2.31 ,Qmax=0.706。所得数值的加权残差均小于3。结果表明与传统方法相比,反应曲面模型法可以得到较好的拟合质量,为药物相互作用的研究提供了一种新颖思路和有效手段。

摘要：Atrial fibrillation is an “invisible killer” of human health. It often induces high-risk diseases, such as myocardial infarction, stroke, and heart failure. Fortunately, atrial fibrillation can be diagnosed and treated early. Low-level vagus nerve stimulation(LL-VNS) is a promising therapeutic method for atrial fibrillation. However, some fundamental challenges still need to be overcome in terms of flexibility,miniaturization, and long-term service of bioelectric stimulation devices. Here, we designed a closedloop self-powered LL-VNS system that can monitor the patient’s pulse wave status in real time and conduct stimulation impulses automatically during the development of atrial fibrillation. The implant is a hybrid nanogenerator(H-NG), which is flexible, light weight, and simple, even without electronic circuits,components, and batteries. The maximum output of the H-NG was 14.8 V and 17.8 μA(peak to peak). In the in vivo effect verification study, the atrial fibrillation duration significantly decreased by 90% after LLVNS therapy, and myocardial fibrosis and atrial connexin levels were effectively improved. Notably, the anti-inflammatory effect triggered by mediating the NF-κB and AP-1 pathways in our therapeutic system is observed. Overall, this implantable bioelectronic device is expected to be used for self-powerability,intelligentization, portability for management, and therapy of chronic diseases.