摘要：触摸感觉为我们的社会、环境的相互作用是批评的。在哺乳动物，很歧视的轻触摸感觉被 A 调停低阀值的 mechanoreceptors。低阀值的 mechanoreceptors 的细胞身体位于背面的根 ganglia 和三叉的 ganglia，它扩大刺激针的绳索和大脑茎的中央设计和刺激专业化 mechanosensory 结束器官的外部设计。这些专业化 mechanosensory 结束机关包括 Meissners 血球细胞， Pacinian 血球细胞，矛尖状的末端， Merkel 房间，和 Ruffini 血球细胞。形态学和这些 mechanosensory 结束机关和他们的刺激神经原的生理的性质被调查了为在一个世纪。另外，在鼠标遗传的最近的进展启用了位于低阀值的 mechanoreceptors 的开发下面的分子的机制的鉴定，它加亮神经营养的因素在这进程发信号和抄写因素活动的关键角色。这里，我们将考察哺乳动物的低阀值的 A 的解剖，生理的性质，和发展 mechanoreceptors。

摘要：Osteoconductive function is remarkably low in bone disease in the absence of bone tissue surrounding the grafting site,or if the bone tissue is in poor ***,an effective bone graft in terms of both osteoconductivity and osteoinductivity is required for clinical ***,the three-dimensional(3D)kagome structure has been shown to be advantageous for bone tissue regeneration due to its mechanical *** this study,a polycaprolactone(PCL)kagome-structure scaffold containing a hyaluronic acid(HA)-based hydrogel was fabricated using a 3D printing *** retention capacity of the hydrogel in the scaffold was assessed in vivo with a rat calvaria subcutaneous model for 3 weeks,and the results were compared with those obtained with conventional 3D-printed PCL grid-structure scaffolds containing HA-based hydrogel and bulk-type HA-based *** retained hydrogel in the kagome-structure scaffold was further evaluated by in vivo imaging system *** further reinforce the osteoinductivity of the kagome-structure scaffold,a PCL kagome-structure scaffold with bone morphogenetic protein-2(BMP-2)containing HA hydrogel was fabricated and implanted in a calvarial defect model of rabbits for 16 *** bone regeneration characteristics were evaluated with hematoxylin and eosin(H&E),Masson’s trichrome staining,and micro-CT image analysis.

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