摘要：As surgical procedures transition from conventional resection to advanced tissue-regeneration technologies,human disease therapy has witnessed a great leap *** particular,three-dimensional(3D)bioprinting stands as a landmark in this setting,by promising the precise integration of biomaterials,cells,and bioactive molecules,thus opening up a novel avenue for tissue/organ *** by the editorial board of Bio-Design and Manufacturing,this review brings together a cohort of leading young scientists in China to dissect the core functionalities and evolutionary trajectory of 3D bioprinting,by elucidating the intricate challenges encountered in the manufacturing of transplantable *** further delve into the translational pathway from scientific research to clinical application,emphasizing the imperativeness of establishing a regulatory framework and rigorously enforcing quality-control ***,this review outlines the strategic landscape and innovative achievements of China in this field and provides a comprehensive roadmap for researchers worldwide to propel this field collectively to even greater heights.

摘要：Near net-shape production of complex parts with higher mechanical properties is one of the most important final goals of the recent researches on the semi-solid *** the knowledge of the influence of every parameter on the properties of final parts is the key in the production of high quality complex *** these parameters forming temperature and velocity,and reheating and holding times have the greatest effects on the final mechanical properties of the *** influence of the parameters of non-dendritic billet production,forming speed,temperature and holding time on the properties of semi-solid extruded parts were ***-slope method was employed in order to produce non-dendritic *** material used was A356 aluminum *** the number of the parameters influencing the final properties of the parts was high(these parameters include:cooling slope angle,ram velocity,temperature and holding time),the final number of the experiments required would be n4,in which n is the number of the states of the parameters(5 in our case).In order to reduce this amount,design of experiments Tachuchi method was employed(design L25).Using this method the number of required experiments was reduced to *** the experiments the prepared semi-solid samples were extruded under isothermal condition and with 5 different ram *** tensile tests were conducted on the extruded parts and the mechanical properties of the parts were *** obtained results analyzed with MiniTab and the influence of each of the parameters and also the percentage of its influence were *** an optimum region for the parameters was *** temperature,ram speed,slope angle and holding time have more important effects descendingly.

摘要：Tissue curvature has long been recognized as an important anatomical parameter that affects intracellular behaviors,and there is emerging interest in applying cell-scale curvature as a designer property to drive cell fates for tissue engineering *** neural cells are known to undergo dramatic and terminal morphological changes during development and curvature-limiting behaviors have been demonstrated in neurite outgrowth studies,there are still crucial gaps in understanding neural cell behaviors,particularly in the context of a three-dimensional(3D)curvature landscape similar to an actual tissue engineering *** this study,we fabricated two substrates of microcurvature(curvature-substrates)that present a smooth and repeating landscape with focuses of either a concave or a convex *** these curvature-substrates,we studied the properties of morphological differentiation in N2a neuroblastoma *** contrast to other studies where two-dimensional(2D)curvature was demonstrated to limit neurite outgrowth,we found that both the concave and convex substrates acted as continuous and uniform mechanical protrusions that significantly enhanced neural polarity and differentiation with few morphological changes in the main cell *** enhanced differentiation was manifested in various properties,including increased neurite length,increased nuclear displacement,and upregulation of various neural *** demonstrating how the micron-scale curvature landscape induces neuronal polarity,we provide further insights into the design of biomaterials utilizing the influence of surface curvature in neural tissue engineering.

摘要：A computer-aided method to design a hybrid layout--tree-shape planar flowlines is presented. In newtype fiowshop layout, the common machines shared by several flowlines could be located together in functional sections. The approach combines traditional cell formation techniques with sequence alignment algorithms. Firstly, a sequence analysis based cell formation procedure is adopted; then the operation sequences for parts are aligned to maximize machines adjacency in hyperedge representations; finally a tree-shape planar flowline will be obtained for each part family. With the help of a sample of operation sequences obtained from industry, this algorithm is illustrated.

摘要：By changing the air gap to a via-typed air gap, the height of the air gap is reduced up to about 50% compared to the height of the trench-typed air gap. The controllable （1 ≤h 〈 2.9） ultra low-k is also easily fabricated by adjusting the space of the via-typed air gap. The via-typed air gap makes the design margin better due to its lower height in the dense and narrow lines.

摘要：A case is made for further developing a branch of systems engineering that focuses on problems and issues which arise in the service sector. We promulgate this special focus not only because of the size and importance of the service sector but also because of the unique opportunities that systems engineering can exploit in the design and joint production and delivery of services. We begin by considering the economic, technological and demographic contexts within which the service sector has flourished; we then address both services, especially emerging services, and systems engineering, followed by a discussion of how to advance the field of service systems engineering, and concluding with several remarks. In particular, a number of service systems engineering methods are identified to enhance the design and production/delivery of services, especially taking advantage of the unique features that characterize services - namely, services, especially emerging services, are information-driven, customer-centric, e-oriented, and productivity-focused.

摘要：This paper aims at the elastic buckling of multilayered thin-walled conical shells with power-law distributed material properties under the axial load and lateral pressure based on the experimental study of palm trunks. The material properties of the shells are assumed to vary continuously in the radial direction. Relations and analytical approaches for linear buckling response are presented by using the layer-wise shell theory. The buckling behaviors of the conical shells subjected to axial and transverse loads are investigated. Parametric study in geometry(relative thickness, relative stiffness and cone angle) is performed to enhance the overall buckling resistance and minimize the weight. Numerical results show the possibility to achieve larger load-carrying capacity by simultaneously optimizing the material and geometric parameters based on the structure of palm trunks.

摘要：This study presents a development of an advanced cyberbased database-enabled design module for low- rise buildings （DEDM-LR） which provides estimation of the wind-induced responses for main wind force resisting frames by making direct use of pressure time histories measured at a large number of pressure taps over a suite of building models. These responses may be considered in lieu of code-specified load effects in which the overall accuracy may be influenced by the inherent simplifications in codes. In addition, this new automated approach is particularly attractive and advantageous as it allows a web-based online analysis/design via intuitive user-friendly interfaces for both the input and output in terms of familiar web-style forms that are nowadays very common in most of web-based services. Presently, the DEDM-LR hosts an aerodynamic database developed by the Tokyo polytechnic University （TPU）, Japan for a variety of building configurations like flat, gable, and hip roofs under suburban terrain flow condition with immediate application to other databases. The paper shows the efficacy and validity of the DEDM-LR by walking through its details and examples on selected gable-roofed buildings. The architecture of DEDM-LR platform offers the ability to pool resources by hosting other databases that may become available in the near future.

摘要：High-accuracy motion trajectory tracking control of a pneumatic cylinder driven by a proportional directional control valve was considered. A mathematical model of the system was developed firstly. Due to the time-varying friction force in the cylinder, unmodeled dynamics, and unknown disturbances, there exist large extent of parametric uncertainties and rather severe uncertain nonlinearities in the pneumatic system. To deal with these uncertainties effectively, an adaptive robust controller was constructed in this work. The proposed controller employs on-line recursive least squares estimation(RLSE) to reduce the extent of parametric uncertainties, and utilizes the sliding mode control method to attenuate the effects of parameter estimation errors, unmodeled dynamics and disturbances. Therefore, a prescribed motion tracking transient performance and final tracking accuracy can be guaranteed. Since the system model uncertainties are unmatched, the recursive backstepping design technology was applied. In order to solve the conflicts between the sliding mode control design and the adaptive control design, the projection mapping was used to condition the RLSE algorithm so that the parameter estimates are kept within a known bounded convex set. Extensive experimental results were presented to illustrate the excellent achievable performance of the proposed controller and performance robustness to the load variation and sudden disturbance.

摘要：The radial deformation design of turbine disk seriously influences the control of gas turbine high pressure turbine(HPT) blade-tip radial running clearance(BTRRC). To improve the design of BTRRC under continuous operation, the nonlinear dynamic reliability optimization of disk radial deformation was implemented based on extremum response surface method(ERSM), including ERSM-based quadratic function(QF-ERSM) and ERSM-based support vector machine of regression(SR-ERSM). The mathematical models of the two methods were established and the framework of reliability-based dynamic design optimization was developed. The numerical experiments demonstrate that the proposed optimization methods have the promising potential in reducing additional design samples and improving computational efficiency with acceptable precision, in which the SR-ERSM emerges more obviously. Through the case study, we find that disk radial deformation is reduced by about 6.5×10–5 m; δ=1.31×10–3 m is optimal for turbine disk radial deformation design and the proposed methods are verified again. The presented efforts provide an effective optimization method for the nonlinear transient design of motion structures for further research, and enrich mechanical reliability design theory.