摘要：The global demand for effective skin injury treatments has prompted the exploration of tissue engineering *** three-dimensional(3D)bioprinting has shown promise,challenges persist with respect to achieving timely and compatible solutions to treat diverse skin *** situ bioprinting has emerged as a key new technology,since it reduces risks during the implantation of printed scaffolds and demonstrates superior therapeutic ***,maintaining printing fidelity during in situ bioprinting remains a critical challenge,particularly with respect to model layering and path *** study proposes a novel optimization-based conformal path planning strategy for in situ bioprinting-based repair of complex skin *** strategy employs constrained optimization to identify optimal waypoints on a point cloud-approximated curved surface,thereby ensuring a high degree of similarity between predesigned planar and surface-mapped 3D ***,this method is applicable for skin wound treatments,since it generates 3D-equidistant zigzag curves along surface tangents and enables multi-layer conformal path planning to facilitate the treatment of volumetric ***,the proposed algorithm was found to be a feasible and effective treatment in a murine back injury model as well as in other complex models,thereby showcasing its potential to guide in situ bioprinting,enhance bioprinting fidelity,and facilitate improvement of clinical outcomes.

摘要：As surgical procedures transition from conventional resection to advanced tissue-regeneration technologies,human disease therapy has witnessed a great leap *** particular,three-dimensional(3D)bioprinting stands as a landmark in this setting,by promising the precise integration of biomaterials,cells,and bioactive molecules,thus opening up a novel avenue for tissue/organ *** by the editorial board of Bio-Design and manufacturing,this review brings together a cohort of leading young scientists in China to dissect the core functionalities and evolutionary trajectory of 3D bioprinting,by elucidating the intricate challenges encountered in the manufacturing of transplantable *** further delve into the translational pathway from scientific research to clinical application,emphasizing the imperativeness of establishing a regulatory framework and rigorously enforcing quality-control ***,this review outlines the strategic landscape and innovative achievements of China in this field and provides a comprehensive roadmap for researchers worldwide to propel this field collectively to even greater heights.

摘要：Higher requirements for the accuracy of relevant models are put throughout the transformation and upgrade of the iron and steel sector to intelligent *** has been difficult to meet the needs of the field with the usual prediction model of mechanical properties of hotrolled *** data and difficult parameter adjustment limit deep learning models based on multi-layer networks in practical applications;besides,the limited discrete process parameters used make it impossible to effectively depict the actual strip processing *** order to solve these problems,this research proposed a new sampling approach for mechanical characteristics input data of hot-rolled strip based on the multi-grained cascade forest(gcForest)*** to the characteristics of complex process flow and abnormal sensitivity of process path and parameters to product quality in the hot-rolled strip production,a three-dimensional continuous time series process data sampling method based on time-temperature-deformation was *** basic information of strip steel(chemical composition and typical process parameters)is fused with the local process information collected by multi-grained scanning,so that the next link’s input has both local and global ***,in the multi-grained scanning structure,a sub sampling scheme with a variable window was designed,so that input data with different dimensions can get output characteristics of the same dimension after passing through the multi-grained scanning structure,allowing the cascade forest structure to be trained ***,actual production data of three steel grades was used to conduct the experimental *** results revealed that the gcForest-based mechanical property prediction model outperforms the competition in terms of comprehensive performance,ease of parameter adjustment,and ability to sustain high prediction accuracy with fewer samples.

摘要：Autologous bone marrow-derived mesenchymal stem cells(BMSCs)have been shown to promote osteogenesis;however,the effects of allogeneic BMSCs(allo-BMSCs)on bone regeneration remain ***,we explored the bone regeneration promotion effect of allo-BMSCs in 3D-printed autologous bone particle(ABP)***,we concurrently printed scaffolds with polycaprolactone,ABPs,and allo-BMSCs for appropriate support,providing bioactive factors and seed cells to promote *** vitro studies showed that ABP scaffolds promoted allo-BMSC osteogenic *** vivo studies revealed that the implantation of scaffolds loaded with ABPs and allo-BMSCs into canine skull defects for nine months promoted *** experiments suggested that only a small portion of implanted allo-BMSCs survived and differentiated into vascular endothelial cells,chondrocytes,and *** implanted allo-BMSCs released stromal cell-derived factor 1 through paracrine signaling to recruit native BMSCs into the defect,promoting bone *** study contributes to our understanding of allo-BMSCs,providing information relevant to their future application.

摘要：Kirigami, the ancient Japanese paper cutting technique, has been applied to achieve high stretchability and low energy loss of designed metallic glass. Despite the exploration of the underlying deformation mechanism of kirigami-inspired structures from the energy point of view, the morphable responses of the kirigami patterns and the origin of the kirigami response are yet to be fully understood. This study reveals the mechanical driven-forms of the kirigami structure with the corresponding deformation stages. Based on the beam deflection theory, the elastic buckling behavior of kirigami metallic glass is manifested and a critical force prediction model is developed. Moreover, a force concentration parameter is introduced in the rigid-plastic deformation stage, predicting the nominal ultimate force. The kirigami-inspired facture force is firstly proposed. The findings of these models are in good agreement with the experimental sizedependent kirigami responses, and expected to provide significant insights into the understanding of the deformation behavior and the design of kirigami metallic glasses.

摘要：本文提出了一种新的设计模式——人辅助设计,以取代传统的计算机辅助设计。在人辅助设计中,计算机可以通过一种新的等几何拓扑优化自动完成整个产品设计,而人类仅需协助轻微修改设计以满足要求。文中提出了一种嵌入域等几何拓扑优化用于设计具有不规则设计域的复杂模型,并且可以基于分层等几何拓扑优化结果自动生成优化结果的可编辑几何模型。测试了三个算例以验证所提出的等几何拓扑优化模式,包括一个具有规则设计域的3D悬臂梁,一个具有不规则设计域的汽车零件和一个具有多尺度结构的MBB梁。结果表明,所提出的等几何拓扑优化模式可以自动生成高质量的优化模型。因此,该技术具有成为革命性技术的巨大潜力,将当前设计模式由计算机辅助设计转变为人辅助设计。

摘要：Exploring the production and application of clean energy has always been the core of sustainable *** a clean and sustainable technology,electrocatalysis has been receiving widespread *** is crucial to achieve efficient,stable and cheap ***,the traditional“trial and error”method is time-consuming,laborious and *** recent years,with the significant increase in computing power,computations have played an important role in electrocatalyst ***,it is still difficult to search for advanced electrocatalysts in the vast chemical space through traditional density functional theory(DFT)***,the development of machine learning and interdisciplinary integration will inject new impetus into targeted design of *** learning is able to predict electrochemical performances with an accuracy close to *** we provide an overview of the application of machine learning in electrocatalyst design,including the prediction of structure,thermodynamic properties and kinetic *** also discuss the potential of explicit solvent model combined with machine learning molecular dynamics in this ***,the favorable circumstances and challenges are outlined for the future development of machine learning in *** studies on electrochemical processes by machine learning will further realize targeted design of high-efficiency electrocatalysts.

摘要：Rotational atherectomy is an effective treatment for severe vascular calcification obstruction,and relies on high-speed grinding(typically 130,000–210,000 r/min)with miniature grinding tools to remove calcified tissue and restore blood ***,reports of intraoperative complications are common because of the grinding force,temperature,and debris directly acting on the body during the grinding process,which can easily cause damage to *** this study,three novel grinding tools were designed and fabricated and a series of experiments have been conducted to analyze the effects of tool geometry and parameters on grinding performance,that is,force,temperature,and specimen surface *** results show that these tools can effectively remove simulated calcified tissue and that they have two motions,rotation and revolution,in the *** higher rotational speeds,grinding force and temperature increase noticeably,while the amount of debris decreases *** addition,by observing the surface morphology of the specimens,we concluded that the material removal rate per unit time is influenced by both rotational speed and tool geometry,and that high rotational speed and a rough tool surface can improve the material removal rate efficiently.

摘要：This paper reports a synergistic design of high-performance BCC high-entropy alloy based on the combined consideration of the principles of intrinsic ductility of elements,maximum atomic size difference for solid solution strengthening and the valence electron concentration criterion for *** single-phase BCC HfNbTaTiV alloy thus designed exhibited a high compressive yield strength of 1350 MPa and a high compressive ductility of>45%at the room *** represents a 50%increase in yield strength relative to a HfNbTaTiZr *** is attributed to the maximized solid solution strengthening effect caused by lattice distortion,which is estimated to be 1094 *** alloy was also able to retain 53%of its yield strength and 77%of its ductility at 700℃.These properties are superior to those of most refractory BCC high-entropy alloys reported in the literature.

摘要：Daily exposure under solar ultraviolet(UV)and infrared(IR)is prone to cause skin cancer and ***-time monitoring of the environmental UV index and IR radiation temperature during outdoor activities can enhance awareness and strengthen personal *** is a challenge to design flexible,wearable devices(with measurement capabilities)that can be integrated with ***,microfluidic spinning technology(MST)was used for the continuous and large-scale fabrication of eco-friendly coresheath Janus fibers with a well-defined axially symmetric Janus *** side of the core was sensitive to UV light and the opposite was sensitive to IR *** woven with Janus fibers showed excellent independent reversible color responses to dual-wavelength *** textiles switched among four colors under UV and IR irradiation,both individually and in *** color gradient of the textiles changed significantly with increasing UV intensity(UV index).After 60 cycles of UV/IR stimulation and 50 washes,the change rate of the comprehensive chromatic aberration(ΔE_(ab)^(*))of the textiles under different conditions was only 0.42%-4.71%.This was attributed to the unique structure of the *** three-line striped textiles demonstrated the potential of the fibers to be used as wearable energy-free realtime visual monitors of the UV index and IR radiation temperature.