摘要：The development of solid-state materials with switchable luminescence in response to stimuli remains a challenge,especially for organic *** crystal water significantly impacts the absorption spectra of organic crystals,it is unclear whether the emission spectra of organic luminescent materials can be systematically manipulated by *** this study,we successfully obtained curcumin monohydrate(Form X),a channel-type hydrate exhibiting crystallization-induced emission(CIE)at 608 nm(orange fluorescence),which contrasted with the conventional forms of aggregation-caused quenching(ACQ).Thermal treatment induced the release of hydration water,resulting in a new anhydrate(Form IV)that emitted yellow-green fluorescence with the emission peak at 575 ***,this approach can be used to track the absorption of curcumin crystals following subcutaneous or intramuscular *** hydratemediated single-crystal-to-single-crystal transition(SCSC)and its associated luminescence transition were reversible and responsive to temperature,offering a green approach for synthesizing and designing aggregation-induced-emission(AIE)-based intelligent luminescent devices for detecting air humidity or drug absorption.

摘要：Nucleocapsid(N) protein plays crucial roles in the life cycle of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2), including the formation of ribonucleoprotein(RNP) complex with the viral *** we reported the crystal structures of the N-terminal domain(NTD) and C-terminal domain(CTD) of the N protein and an NTD-RNA complex. Our structures reveal a unique tetramer organization of NTD and identify a distinct RNA binding mode in the NTD-RNA complex, which could contribute to the formation of the RNP complex. We also screened small molecule inhibitors of N-NTD and N-CTD and discovered that ceftriaxone sodium, an antibiotic, can block the binding of RNA to NTD and inhibit the formation of the RNP complex. These results together could facilitate the further research of antiviral drug design targeting N protein.

摘要：The purpose of this review is to provide medical researchers,especially those without a bioinformatics background,with an easy-to-understand summary of the concepts and technologies used in microbiome ***,we define primary concepts such as microbiota,microbiome,and ***,we discuss study design schemes,the methods of sample size calculation,and the methods for improving the reliability of *** emphasize the importance of negative and positive controls in this ***,we discuss statistical analysis methods used in microbiome research,focusing on problems with multiple comparisons and ways to compare β-diversity between ***,we provide step-by-step pipelines for bioinformatics *** summary,the meticulous study design is a key step to obtaining meaningful results,and appropriate statistical methods are important for accurate interpretation of microbiome *** step-by-step pipelines provide researchers with insights into newly developed bioinformatics analysis methods.

摘要：Dear Editor,Ginseng has been traditionally used as herbal medicine in Asia for thousands of years to enhance physical performance and to increase resistance to stress and aging,and has been developed into various kinds of dietary supplement with increasing market demand [1].Its active constituents are ginsenosides,a group of triterpene saponins (ca.2％ in Panax ginseng dried roots) [1].However,the main functional component detected in mammalian blood or organs after oral administration of ginseng or ginsenosides is compound K (CK) [2],which presents bioactivities of anti-inflammation,hepatoprotection,antidiabetes and anti-cancer in experiments of in vitro cell biology and/or in vivo animal models (Supplementary information,Table S1).Recently,CK was approved by the China Food and Drug Administration to commence clinical trials (CDEL20130379) for arthritis prevention and treatment.

摘要：The hydrogenation of CO_(2) into methanol has attracted much attention and In_(2)O_(3) is a promising *** metal elements into In_(2)O_(3)(M/In_(2)O_(3))is one of the main strategies to improve its ***,its mechanism and active sites remain unclear and need to be further ***,the noble‐metal‐free In_(x)‐Co_(y) oxides catalysts were ***‐improved performance and obvious product selectivity shift were *** optimized catalyst(In_(1)‐Co_(4))(9.7 mmol g_(cat)^(–1) h^(–1))showed five times methanol yields than pure In_(2)O_(3)(2.2 mmol g_(cat)^(–1) h^(–1))(P=4.0 MPa,T=300°C,GHSV=24000 cm^(3)_(STP) g_(cat)^(–1) h^(–1),H_(2):CO_(2)=3).And the cobalt‐catalyzed CO_(2) methanation activity was suppressed,although cobalt was most of the metal *** unravel this selectivity shift,detailed catalysts performance evaluation,together with several in‐situ and ex‐situ characterizations,were employed on cobalt and In‐Co for comparative *** results indicated CO_(2) hydrogenation on cobalt and In‐Co catalyst both followed the formate pathway,and In‐Co reconstructed and generated a surface In_(2)O_(3)‐enriched core‐shell‐like structure under a reductive *** enriched In_(2)O_(3) at the surface significantly enhanced CO_(2) adsorption capacity and well stabilized the intermediates of CO_(2) ***_(2) and carbon‐containing intermediates adsorbed much stronger on In‐Co than cobalt led to a feasible surface C/H ratio,thus allowing the*CH_(3)O to desorb to produce CH_(3)OH instead of being over‐hydrogenated to CH_(4).