摘要：根据沿着重复轴的一种新动态 linearization 技术，双阶段的最佳的反复的学习控制为非线性、非仿射的分离时间的系统被介绍。双阶段显示二个最佳的学习阶段分别地被设计反复地改进控制输入顺序和学习获得。主要特征是控制器设计和集中分析仅仅取决于动态系统的 I/O 数据。换句话说，没有知道系统的任何另外的知识，我们能容易选择控制参数。模拟学习沿着重复轴说明介绍方法的几何集中，在哪个马路的一个例子控制为它的内在的工程重要性是引人注目的交通反复的学习。

摘要：Tracheal stents are an important form of treatment for benign or malignant central airway ***,the mechanical behavior of current tracheal stents is significantly different from that of the native trachea,which leads to a variety of serious *** this study,inspired by the structure of the native trachea,a wavy non-uniform ligament chiral tracheal stent is proposed,in which J-shaped stress-strain behavior and negative Poisson's ratio response are achieved by replacing the tangential ligament of tetrachiral and anti-tetrachiral hybrid structure with a wavy non-uniform *** the combination of theoretical analysis,finite element analysis and experimental tests,a wide range of desired J-shaped stress-strain curves are explored to mimic the native porcine trachea by tailoring the stent ***,the negative Poisson’s ratio and auxetic diameter curves versus axial strain of the stent are also studied in detail,thus contributing to the enhancement of cross-section ventilation and reducing the migration of the *** novel tracheal stent with a unique microstructure shows a potential to perfectly match the physiological activities of the native trachea and thereby reduce potential complications.

摘要：High-entropy alloys(HEAs)have attracted tremendous attention owing to their controllable mechanical properties,whereas additive manufacturing(AM)is an efficient and flexible processing route for novel materials ***,a profound appraisal of the fundamental material physics behind the strengthening of AM-printed HEAs upon low/intermediate-temperature annealing is *** this work,Co CrFe Ni Mn HEAs have been prepared using laser-engineered net shaping(LENS)and subsequently annealed at different *** Co Cr Fe Ni Mn HEA annealed at intermediate-temperature(873 K)exhibits a strong strain hardening capability,resulting in ultimate strength of 725 MPa and plasticity of 22%.A ternary heterogeneous strengthening mechanism is proposed to explain this phenomenon,in which equiaxed grains,columnar grains,andσprecipitates play different roles during tensile *** resultant excellent strength and ductility can be ascribed to the heterostructure-induced *** equiaxed grains provide adequate grain boundaries(GBs),which induce dislocation plugging-up and entanglement;the columnar grains induce the onset and arrest of the dislocations for plastic deformation;and theσprecipitates hinder the movement of slip *** results provide new insights into overcoming the strength-ductility trade-off of LENS-printed HEAs with complex geometries.

摘要：This paper proposes an additive nanomanufacturing approach to fabricate a personalized lab-on-a-chip fluorescent peptide nanoparticles （f-PNPs） array for simultaneous multi-biomarker detection that can be used in Alzheimer＇s disease （AD） diagnosis. We will discuss optimization techniques for the additive nanomanufacturing process in terms of reliability, yield and manufacturing efficiency. One contribution of this paper lies in utilization of additive nanomanufacturing techniques to fabricate a patient-specific customize-designed lab-on-a-chip device for personalized AD diagnosis, which remains a major challenge for biomedical engineering. Through the integrated bio-design and bio-manufacturing process, doctor＇s check- up and computer-aided customized design are integrated into the lab-on-a-chip array for patient-specific AD diagnosis. In addition, f-PNPs with targeting moieties for personalized AD biomarkers will be self-assembled onto the customized lab-on-a- chip through the additive nanomanufacturing process, which has not been done before. Another contribution of this research is the personalized lab-on-a-chip f-PNPs array for AD diagnosis utilizing limited human blood. Blood-based AD assessment has been described as ＂the holy grail＂ of early AD detection. This research created the computer-aided design, fabrication through additive nanomanufacturing, and validation of the f-PNPs array for AD diagnosis. This is a highly interdisciplinary research contributing to nanotechnology, biomaterials, and biomedical engineering for neurodegenerative disease. The conceptual work is preliminary with intent to introduce novel techniques to the application. Large-scale manufacturing based on the proposed framework requires extensive validation and optimization.

摘要：Non-intrusive measurement technology is of great interest for the electrical utilities in order to avoid an interruption in the normal operation of the supply network during diagnostics measurements and inspections. Inductively coupled electromagnetic sensing provides a possibility of non-intrusive measurements for online condition monitoring of the electrical components in a Medium Voltage (MV) distribution network. This is accomplished by employing Partial Discharge (PD) activity monitoring, one of the successful methods to assess the working condition of MV components but often requires specialized equipment for carrying out the measurements. In this paper, Rogowski coil sensor is presented as a robust solution for non-intrusive measurements of PD signals. A high frequency prototype of Rogowski coil is designed in the laboratory. Step-by-step approach of constructing the sensor system is presented and performance of its components (coil head, damping component, integrator and data acquisition system) is evaluated using practical and simulated environments. Alternative Transient Program-Electromagnetic Transient Program (ATP-EMTP) is used to analyze the designed model of the Rogowski coil. Real and simulated models of the coil are used to investigate the behavior of Rogowski coil sensor at its different stages of development from a transducer coil to a complete measuring device. Both models are compared to evaluate their accuracy for PD applications. Due to simple design, flexible hardware, and low cost of Rogowski coil, it can be considered as an efficient current measuring device for integrated monitoring applications where a large number of sensors are required to develop an automated online condition monitoring system for a distribution network.

摘要：We propose the concept of thermal demultiplexer, which can split the heat flux in different frequency ranges intodifferent directions. We demonstrate this device concept in a honeycomb lattice with dangling atoms. From the view ofeffective negative mass, we give a qualitative explanation of how the dangling atoms change the original transport *** first design a two-mass configuration thermal demultiplexer, and find that the heat flux can flow into different ports incorresponding frequency ranges roughly. Then, to improve the performance, we choose the suitable masses of danglingatoms and optimize the four-mass configuration with genetic algorithm. Finally, we give out the optimal configuration witha remarkable effect. Our study finds a way to selectively split spectrum-resolved heat to different ports as phonon splitter,which would provide a new means to manipulate phonons and heat, and to guide the design of phononic thermal devices inthe future.

摘要：Cryobioprinting has tremendous potential to solve problems to do with lack of shelf availability in traditional bioprinting by combining extrusion bioprinting and *** order to ensure the viability of cells in the frozen state and avoid the possible toxicity of dimethyl sulfoxide(DMSO),DMSO-free bioink design is critical for achieving successful cryobioprinting.A nontoxic gelatin methacryloyl-based bioink used in cryobioprinting is composed of cryoprotective agents(CPAs)and a buffer *** selection and ratio of CPAs in the bioink directly affect the survival of cells in the frozen ***,the development of universal and efficient cryoprotective bioinks requires extensive *** first compared two commonly used CPA formulations via experiments in this *** show that the effect of using ethylene glycol as the permeable CPA was 6.07%better than that of *** datasets were obtained and four machinelearning models were established to predict experimental *** predictive powers of multiple linear regression(MLR),decision tree(DT),random forest(RF),and artificial neural network(ANN)approaches were compared,suggesting an order of ANN>RF>DT>*** final selected ANN model was then applied to another *** reveal that this machine-learning method can accurately predict the effects of cryoprotective bioinks composed of different *** also suggest that the formulations presented here have *** findings are likely to greatly accelerate research and development on the use of bioinks for cryobioprinting.

摘要：目的:污染物质的存在会引起海底环境中的许多经济和生态问题。本文以遥控无人潜水器(ROV)为基础承载平台,实现基于空化喷射清洗技术的水下结构表面附着物清洗。创新点:将空化射流清洗技术与ROV结合,并利用空化泡在清洗表面区域溃灭产生的微射流冲击,以达到清理水下表面附着物和污垢层的目的。方法:1.通过计算流体动力学(CFD)仿真与实验,针对ROV水下喷射模型,在不同状态和不同参数下对水下射流的规律进行测试与比较。2.实验对比验证在不同喷射距离下所设计的空化射流清洗装置清理海底生物的能力。结论:1.当入口压力P=30 MPa,孔径d=2 mm,出口长度L=16 mm和出口直径D=16 mm时,水下喷嘴具有更高的清洁度和清洁效率,可以满足清洁要求。***喷嘴离水下泥浆越远,冲刷深度越浅。3.所设计的ROV空化喷射清洁装置与目标的距离越近,清洗强度越高;然而,当压力恒定且距离太近时,过度阻力会削弱冲洗强度。

摘要：In systems biology, the dynamics of biological networks are often modeled with ordinary differential equations (ODEs) that encode interacting components in the systems, resulting in highly complex models. In contrast, the amount of experimentally available data is almost always limited, and insufficient to constrain the parameters. In this situation, parameter estimation is a very challenging problem. To address this challenge, two intuitive approaches are to perform experimental design to generate more data, and to perform model reduction to simplify the model. Experimental design and model reduction have been traditionally viewed as two distinct areas, and an extensive literature and excellent reviews exist on each of the two areas. Intriguingly, however, the intrinsic connections between the two areas have not been recognized. Experimental design and model reduction are deeply related, and can be considered as one unified framework. There are two recent methods that can tackle both areas, one based on model manifold and the other based on profile likelihood. We use a simple sum-of-two-exponentials example to discuss the concepts and algorithmic details of both methods, and provide Matlab-based code and implementation which are useful resources for the dissemination and adoption of experimental design and model reduction in the biology community. From a geometric perspective, we consider the experimental data as a point in a high-dimensional data space and the mathematical model as a manifold living in this space. Parameter estimation can be viewed as a projection of the data point onto the manifold. By examining the singularity around the projected point on the manifold, we can perform both experimental design and model reduction. Experimental design identifies new experiments that expand the manifold and remove the singularity, whereas model reduction identifies the nearest boundary, which is the nearest singularity that suggests an appropriate form of a reduced

摘要：Tissue-engineered cartilage(TEC)remains a potential alternative for the repair of articular cartilage ***,there has been a significant different between the properties of TEC and those of natural *** have shown that mechanical stimulation such as compressive load can help regulate matrix remodelling in TEC,thus affecting its biomechanical ***,the influences of shear induced from the tissue fluid phase have not been well studied and may play an important role in tissue regeneration especially when integrated with the compressive ***,the aim of this study was to quantitatively investigate the effects of combined loading mechanisms on TEC in vitro.A bespoke biosimulator was built to incorporate the coupled motion of compression,friction and *** specimens,encapsulating freshly isolated rabbit chondrocytes in a hydrogel,were cultured within the biosimulator under various mechanical stimulations for 4 weeks,and the tissue activity,matrix contents and the mechanical properties were *** groups were categorized according to different mechanical stimulation combinations,including strain(5-20%at 5%intervals)and frequency(0.25 Hz,0.5 Hz,1 Hz),and the effects on tissue behaviour were *** the dynamic culture process,a combined load was applied to simulate the combined effects of compression,friction and shear on articular cartilage during human *** results indicated that a larger strain and higher frequency were more favourable for the specimen in terms of the cell proliferation and extracellular matrix ***,the combined mechanical stimulation was more beneficial to matrix remodelling than the single loading ***,the contribution of the combined mechanical stimulation to the engineered cartilaginous tissue matrix was not sufficient to impede biodegradation of the tissue with culture time.