摘要：Hypoxia is a typical feature of the tumor microenvironment,one of the most critical factors affecting cell behavior and tumor ***,the lack of tumor models able to precisely emulate natural brain tumor tissue has impeded the study of the effects of hypoxia on the progression and growth of tumor *** study reports a three-dimensional(3D)brain tumor model obtained by encapsulating U87MG(U87)cells in a hydrogel containing type I *** also documents the effect of various oxygen concentrations(1%,7%,and 21%)in the culture environment on U87 cell morphology,proliferation,viability,cell cycle,apoptosis rate,and ***,it compares two-dimensional(2D)and 3D *** comparison purposes,cells cultured in flat culture dishes were used as the control(2D model).Cells cultured in the 3D model proliferated more slowly but had a higher apoptosis rate and proportion of cells in the resting phase(G0 phase)/gap I phase(G1 phase)than those cultured in the 2D ***,the two models yielded significantly different cell ***,hypoxia(e.g.,1%O2)affected cell morphology,slowed cell growth,reduced cell viability,and increased the apoptosis rate in the 3D *** results indicate that the constructed 3D model is effective for investigating the effects of biological and chemical factors on cell morphology and function,and can be more representative of the tumor microenvironment than 2D culture *** developed 3D glioblastoma tumor model is equally applicable to other studies in pharmacology and pathology.

摘要：本文研究了典型液压集成块中具有不同刀尖角容腔的直角流道的流场特征。搭建了低速可视化试验台,采用2D-PIV技术测量了具有不同刀尖角容腔结构的直角流道流场。建立了全三维数值模型并开展数值模拟研究,通过与粒子图像测量(PIV)测量结果进行比较,比较了七种湍流模型在流场预测中的准确性。通过定义权重误差函数K,筛选出,S-A模型作为合适的湍流模型。通过3因素3水平响应面数值试验,研究了流道连接类型、容腔直径和容腔长径比对压力损失的影响。结果表明,Box-Benhnken Design(BBD)模型可以准确预测总压力损失。最优模型是Ⅱ型流道连接,直径为14.64mm,容腔长径比为67.53%,总压力损失相对于最差模型可下降11.15%。如能进一步采用圆弧型直角转弯流道,总压力损失可降低64.75%,这为液压集成块流道优化设计提供了新的方向。

摘要：党中央决定成立全面深化改革领导小组,负责改革的总体设计、统筹协调、整体推进、督促落实。这意味着变革管理被提上重要议事日程。从变革管理角度系统梳理和审视改革开放以来国务院七轮机构改革历程,国务院机构设置变革呈现出明显的渐进和稳健特征,职能转变是历次改革的核心和亮点。政府职能转变呈现出明显的两段论特色:第一阶段的重点是政府经济管理职能的转变;第二阶段的重点是加强和改善宏观调控,强化社会管理和公共服务职能。但就方案设计而言,近10年来有关职能转变的目标和措施等具体性方面明显不足,具体措施及其成效与三轮机构改革方案之间的关系难以确立。因此,"机构改革是否也需要改革"成为新的实践命题,需要从战略定位、推进方式、公共责任、总体设计等方面进行思考。

摘要：目的:研究向基层机构倾斜的门诊报销制度(即覆盖门诊服务且县、乡、村门诊报销比例由低到高的制度设计)对高血压患者门诊服务利用的影响。方法:从宁夏回族自治区"创新支付制度项目"获取2009年和2011年入户调查的面板数据,采用自然试验的设计,针对干预组和对照组,利用双重差分法(difference-in-differences)进行分析,其结果指标为自报高血压患者样本被调查前3个月内是否就诊及其主要就诊地点的选择。结果:相较于对照组,倾向于基层的新农合门诊覆盖使得干预组高血压患者被调查前3个月内从未就诊的概率下降10.2%,并使患者将村卫生室作为主要就诊地点的概率提高了15.7%。结论:门诊报销比例向基层机构倾斜,可以引导高血压患者在疾病风险较小时就近利用门诊服务。

摘要：2009年以来,我国多个地区都开展了各具特色的卫生改革尝试。总结这些改革的经验对于深化我国医药卫生体制有着积极意义。文章以宁夏回族自治区盐池县县级医院支付制度改革为核心,系统阐述了这次改革的政策安排并对政策效果进行了初步的评价。通过剖析这些安排对医疗服务提供者的激励作用,着重分析了这次改革如何实现"医、患、保多方共赢"的政策目标。

摘要：本文针对长三角地区高速铁路(高铁)发展对中国的影响进行了分析。在介绍和进行文献综述的基础上，提出了一种基于路网系统的模型指导整个研究。一方面，在三角洲的高铁项目预计将产生显著的运输效率带来的运输和非运输利益。因此，上海和其他主要城市的辐射效应将极大地促进主要的高铁走廊沿线的城市和地区发展，而整个大都市将在经济、社会和文化上更加一体化。但另一方面，高铁也会造成严重的社会和地理上的不平等问题，需要尽快解决。实证研究证实了平底锅模型的提出。

摘要：What is the psychological mechanism of the radical behavior towards the public affairs?Carl Jung’s analytical psychology can be an approach to this *** tested 268 people on their cognitive,emotional and behavioral reflex on suicide components expression and terrorism ideology *** results shows that,based on psychoanalytical dipole model,“mine/alien’s”archetype’s polarization factors impacts the shahidism behavior.

摘要：The mechanism of language’s impact on people’s mind is a black box problem in *** the 21st century it crossed the field of psychology and became an urgent problem in artificial intelligence and *** language has a highly effective role amongst all human linguistic materials on psychological *** is the mechanism of religious language impacts on the brain?This study examined the relationship between religious linguistic rhythms and brain wave *** chose 36 Koran’s sur as language material and counted the length of every sentence for definition its’*** using the same method we compared with other religious and political linguistic *** data shows the common rhythmic structure among all those language ***,we consider that clock rhythms display of bilateral regulation,psychotherapeutic impact of the canonic texts is based on harmonization inter-hemisphere attitudes and other rhythms.