摘要：Three-dimensional printing technologies exhibit tremendous potential in the advancing fields of tissue engineering and regenerative medicine due to the precise spatial control over depositing the *** their widespread utilization and numerous advantages,the development of suitable novel biomaterials for extrusion-based 3D printing of scaffolds that support cell attachment,proliferation,and vascularization remains a ***-material composite hydrogels present incredible potential in this ***,in this work,a multi-material composite hydrogel with a promising formulation of chitosan/gelatin functionalized with egg white was developed,which provides good printability and shape *** addition,a series of comparative analyses of different crosslinking agents and processes based on tripolyphosphate(TPP),genipin(GP),and glutaraldehyde(GTA)were investigated and compared to select the ideal crosslinking strategy to enhance the physicochemical and biological properties of the fabricated *** of the results indicate that the composite hydrogel and the resulting scaffolds utilizing TPP crosslinking have great potential in tissue engineering,especially for supporting neo-vessel growth into the scaffold and promoting angiogenesis within engineered tissues.

摘要：Tissue engineering is an emerging means for resolving the problems of tissue repair and organ replacement in regenerative *** supply of nutrients and oxygen to cells in large-scale tissues has led to the demand to prepare blood ***-based tissue engineering approaches are effective methods to form new blood vessel *** demand for blood vessels prompts systematic research on fabrication strategies of vascular scaffolds for tissue *** advances in 3D printing have facilitated fabrication of vascular scaffolds,contributing to broad prospects for tissue *** review presents state of the art on modeling methods,print materials and preparation processes for fabrication of vascular scaffolds,and discusses the advantages and application fields of each ***,significance and importance of scaffold-based tissue engineering for vascular regeneration are *** materials and preparation processes are discussed in *** a focus is placed on preparation processes based on 3D printing technologies and traditional manufacturing technologies including casting,electrospinning,and Lego-like *** related studies are *** of vascular scaffolds to clinical application is ***,four trends of 3D printing of tissue engineering vascular scaffolds are presented,including machine learning,near-infrared photopolymerization,4D printing,and combination of self-assembly and 3D printing-based methods.

摘要：High performance force sensors often encounter the conflicting requirements of high resolution and large measurement *** address this problem,this paper presents a conceptual design of a novel uniaxial force sensor with large range and dual-stage force resolutions which enables us to measure forces within a wide range with satisfied *** newly developed force sensor features an aluminum alloy body with a probe to transfer external forces into the sensing *** employs an optical linear encoder to detect the displacement of the sensing *** sensing scheme may immunize outside electromagnetic noises and therefore enhance the performance of the sensor thanks to its digital signal *** this paper,an accurate,analytical model for calculating the static stiffness and dynamics of the system was developed by using pseudo-rigid-body-model(PRBM)*** optimize the design,finite element simulations were *** a prototype sensor was fabricated,preliminary characterization tests were carried out to verify the accuracy of the theoretical model and demonstrate the effectiveness of the *** experiment results indicate that the structure of the new sensor is compact,and it has the ability to measure both micro range and macro range forces within one setup,meanwhile keeps very fine resolutions.

摘要：Cholangiocarcinoma(CCA)is characterized by heterogeneous mutations and a refractory ***,the development of a model for effective drug screening is urgently *** the established therapeutic testing models for CCA are often ineffective,we fabricated an enabling three-dimensional(3D)-bioprinted CCA-on-a-chip model that to a good extent resembled the multicellular microenvironment and the anatomical microstructure of the hepato-vascular-biliary system to perform high-content antitumor drug ***,cholangiocytes,hepatocytes,and vascular endotheliocytes were employed for 3D bioprinting of the models,allowing for a high degree of spatial and tube-like microstructural ***,it was possible to observe CCA cells attached to the surfaces of the gelatin methacryloyl(GelMA)hydrogelembedded microchannels and overgrown in a thickening manner,generating bile duct stenosis,which was expected to be analogous to the in vivo *** 4000 differentially expressed genes were detected in the CCA cells in our 3D coculture model compared to the traditional two-dimensional(2D)*** screening revealed that the CCA cells grown in the 3D traditional model were more sensitive to the antitumoral prodrug than those in the 2D monoculture due to drug biotransformation by the neighboring functional *** study provides proof-of-concept validation of our bioprinted CCA-on-a-chip as a promising drug screening model for CCA treatment and paves the way for potential personalized medicine strategies for CCA patients in the future.

摘要：Based on satisfactory control strategy,a new method for robust passive fault tolerant controller is proposed for a class of uncertain discrete-time systems subject to actuator *** state-feedback gain matrix is calculated by linear matrix inequality(LMI)*** designed controller guarantees that the closed-loop system meets the pre-specified consistent constraints on circular pole index and steady-state variance index simultaneously for normal case and possible actuator fault *** consistency of the performance indices is ***,with the mentioned indices constraints,a solution is obtained by convex optimal technique for the robust satisfactory fault-tolerant controller with optimal control-cost.

摘要：Drop-on-demand (DOD) bioprinting has been widely used in tissue engineering due to its highthroughput efficiency and cost effectiveness. However, this type of bioprinting involves challenges such as satellite generation, too-large droplet generation, and too-low droplet speed. These challenges reduce the stability and precision of DOD printing, disorder cell arrays, and hence generate further structural errors. In this paper, a multi-objective optimization (MOO) design method for DOD printing parameters through fully connected neural networks (FCNNs) is proposed in order to solve these challenges. The MOO problem comprises two objective functions: to develop the satellite formation model with FCNNs;and to decrease droplet diameter and increase droplet speed. A hybrid multi-subgradient descent bundle method with an adaptive learning rate algorithm (HMSGDBA), which combines the multisubgradient descent bundle (MSGDB) method with Adam algorithm, is introduced in order to search for the Pareto-optimal set for the MOO problem. The superiority of HMSGDBA is demonstrated through comparative studies with the MSGDB method. The experimental results show that a single droplet can be printed stably and the droplet speed can be increased from 0.88 to 2.08 m·s^-1 after optimization with the proposed method. The proposed method can improve both printing precision and stability, and is useful in realizing precise cell arrays and complex biological functions. Furthermore, it can be used to obtain guidelines for the setup of cell-printing experimental platforms.

摘要：为了提高面齿轮加工精度和缩短滚齿加工周期,本文提出了一种装配式球形滚刀加工面齿轮精密展成滚齿方法。第一,分析了圆柱齿轮至球形滚刀基蜗杆演变机理,设计了球形滚刀基蜗杆,建立了球形滚刀基蜗杆和螺旋线方程。第二,基于已有的滚刀设计方法,分析了装配式球形滚刀研制方法,设计了装配式球形滚刀刀齿和基体,完成了整体装配。第三,基于面齿轮滚齿加工的需求,开发了滚齿加工数控机床,建立了面齿轮齿面方程。第四,为了减少由等效安装误差引起的面齿轮加工误差,建立了误差分析模型,分析了各误差对面齿轮齿面的影响。最后,完成了球形滚刀装配和面齿轮滚齿试验。根据测量结果,调整面齿轮滚齿加工参数,齿面偏差得到显著降低。

摘要：The rapid development of information and communication technologies(ICTs)and cyber-physical systems(CPSs)has paved the way for the increasing popularity of smart ***-awareness is an important facet of product *** artifacts,various bio-systems are naturally characterized by their extraordinary *** inspired design(BID)is one of the most commonly employed design ***,few studies have examined the BID of context-aware smart products to *** paper presents a structured design framework to support the BID of context-aware smart *** meaning of context-awareness is defined from the perspective of product *** framework is developed based on the theoretical foundations of the situated function-behavior-structure ontology.A structured design process is prescribed to leverage various biological inspirations in order to support different conceptual design activities,such as problem formulation,structure reformulation,behavior reformulation,and function *** existing design methods and emerging design tools are incorporated into the framework.A case study is presented to showcase how this framework can be followed to redesign a robot vacuum cleaner and make it more context-aware.

摘要：本文通过人工神经网络方法实现多次搭接激光冲击作用下材料残余应力与显微硬度的预测。以镍基粉末冶金高温合金FGH95为实验材料,基于正交实验设计的思路,确定了多次搭接激光冲击强化的实验参数。利用X射线应力测量仪和显微硬度计分别测量了实验试件激光冲击强化处理前后的残余应力和显微硬度分布,并对残余应力和显微硬度变化规律进行了简要分析。构建了4层网络结构(4-N-(N-1)-2)的人工神经网络预测模型,其中输入为激光能量、光斑搭接率、冲击次数和深度,输出为残余应力和显微硬度。对不同网络结构的预测性能进行了比较和分析。在最优的模型下(网络结构为4-7-6-2),预测值与实验值十分吻合,预测效果极佳。此外,基于人工神经网络的方法,还研究了激光冲击强化工艺参数对材料响应的影响。研究表明,在实验数据较为缺乏的情况下,人工神经网络是预测多次搭接激光冲击作用下材料残余应力和显微硬度的有效方法。

摘要：Over last few years, web services, Java 2 and XML have provided the cheaper means for trading partners to make use of EDI. It is now possible to share data with less reliance on expensive dedicated EDI networks. The second comes the realization that Product Definition can be reused by virtually all business processes downstream. This has made collaborative product development a practical reality. These technologies have enabled effective implementation of Product Lifecycle Management (PLM) Solutions. This paper presents a literature review about PLM solutions, looking at its definitions, through to its need and scope of applications. It also presents the most generally envisaged architecture, explaining as to how it may be looked at and what it is expected to deliver. At the end it examines the market trend and revenue growth over recent years including future trends for the most prominent vendors pitched in the field of PLM solutions.