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Design, Synthesis and SAR Studies of Novel and Potent Dipeptidyl Peptidase 4 Inhibitors: 收藏
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引用; 《Chinese Journal of Chemistry》2021年第1期39卷 115-120页; 作者：Na Luo Xiaoyu Fang Mingbo Su Xinwen Zhang Dan Li Honglin Li Shiliang Li Zhenjiang ZhaoShanghai Key Laboratory of New Drug DesignSchool of PharmacyEast China University of Science and Technology130 Meilong RoadShanghai 200237China State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences555 Zhuchongzhi RoadShanghai 201203China Shandong Biopolar Dichang Pharmaceutical Co.LtdRM2306No.786 Linzi AvenueZiboShandong 255400China; Dipeptidyl peptidase 4(DPP-4)is a clinically validated target for the treatment of type 2 diabetes mellitus(T2DM).To disco.er novel and potent DPP-4 inhibitors,three series of co.pounds were designed and synthesized i...; Dipeptidyl peptidase 4(DPP-4)is a clinically validated target for the treatment of type 2 diabetes mellitus(T2DM).To disco.er novel and potent DPP-4 inhibitors,three series of co.pounds were designed and synthesized in this study based on our previously identified novel scaffold of 2-phenyl-3,4-dihydro-2H-benzo[f]*** the designed co.pounds,41d-1 was the most po tent one with an IC_(50) value of 16.00 nM.; 来源：详细信息评论

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