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Design, synthesis and in vitro evaluation of L-amino acid esters prodrugs of acyclic nucleoside phosphonates as anti-HBV agent: 收藏
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引用; 《Chinese Chemical Letters》2007年第7期18卷 817-819页; 作者：Xiao Zhong Fu Sai Hong Jiang Jian Xin Yu She Yang RU Yun JiSchool of Pharmacy Guiyang Medical College Guiyang 550004 China State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Shanghai Institute for Biological SciencesChinese Academy of Science Shanghai 201203 China Shanghai Fudan-Yueda Bio-Tech Co. Ltd. Shanghai 201203 China; A series of novel L-amino acid esters prodrugs of acyclic nucleoside phosphonates was synthesized and their anti-HBV activity was evaluated in HepG2 2.2.15 cells. co.pound 1d exhibited more potent anti-HBV activity an...; A series of novel L-amino acid esters prodrugs of acyclic nucleoside phosphonates was synthesized and their anti-HBV activity was evaluated in HepG2 2.2.15 cells. co.pound 1d exhibited more potent anti-HBV activity and lower cytotoxicity than those of adefovir dipivoxil with EC50 and CC50 values of 0.207 μmol/L and 2530 μmol/L, respectively.; 来源：详细信息评论

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