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检索条件"机构=Shenzhen Institute of Synthetic Biology"
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Dissecting PCNA function with a systematically designed mutant library in yeast
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《Journal of Genetics and Genomics》2019年 第6期46卷 301-313页
作者:Qingwen Jiang Weimin Zhang Chenghao Liu Yicong Lin Qingyu Wu Junbiao DaiCenter for Synthetic and Systems Biology School of Life Sciences Tsinghua University Beijing 100084 China Shenzhen Key Laboratory of Synthetic Genomics and Center for Synthetic Genomics Institute of Synthetic Biology Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen 518055 China Department of Biology. Brandeis University. Massachusetts 02454 USA 
Proliferating cell nuclear antigen (PCNA), encoded by POL30 in Saccharomyces cerevisiae, is a key component of DNA metabolism. Here, a library consisting of 304 PCNA mutants was designed and constructed to probe the c...
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Improving the Efficiency and Orthogonality of Genetic Code Expansion
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《BioDesign Research》2022年 第1期2022卷 248-260页
作者:Xian Fu Yijian Huang Yue ShenBGI-ShenzhenShenzhen 518083China Guangdong Provincial Key Laboratory of Genome Read and WriteShenzhen 518120China School of Future TechnologyUniversity of Chinese Academy of SciencesBeijing 100049China Shenzhen Institute of Synthetic BiologyShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China 
The site-specific incorporation of the noncanonical amino acid(ncAA)into proteins via genetic code expansion(GCE)has enabled the development of new and powerful ways to learn,regulate,and evolve biological functions i...
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Biological and Molecular Components for Genetically Engineering Biosensors in Plants
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《BioDesign Research》2022年 第1期2022卷 19-37页
作者:Yang Liu Guoliang Yuan Md MahmudulHassan Paul E.Abraham Julie C.Mitchell Daniel Jacobson Gerald A.Tuskan Arjun Khakhar June Medford Cheng Zhao Chang-Jun Liu Carrie A.Eckert Mitchel J.Doktycz Timothy J.Tschaplinski Xiaohan YangBiosciences DivisionOak Ridge National LaboratoryOak RidgeTennessee37831USA The Center for Bioenergy InnovationOak Ridge National LaboratoryOak RidgeTennessee37831USA Department of Genetics and Plant BreedingPatuakhali Science and Technology UniversityDumkiPatuakhali8602Bangladesh Departmentof BiologyColorado State UniversityFort CollinsColorado80523USA Shenzhen BranchGuangdong Laboratory for Lingnan Modern AgricultureKey Laboratory of Synthetic BiologyMinistry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese A cademy of Agriculural SciencesShenzhen 518120China Biology DepartmentBrookhaven National LaboratoryUptonNew York 11973USA 
Plants adapt to their changing environments by sensing and responding to physical,biological,and chemical *** to their sessile lifestyles,plants experience a vast array of external stimuli and selectively perceive and...
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A versatile biosensing platform coupling CRISPR-Cas12a and aptamers for detection of diverse analytes
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《Science Bulletin》2021年 第1期66卷 69-77,M0004页
作者:Xiangxiang Zhao Shanshan Li Guang Liu Zhong Wang Zhiheng Yang Quanwei Zhang Mindong Liang Jiakun Liu Zilong Li Yaojun Tong Guoliang Zhu Xinye Wang Lan Jiang Weishan Wang Gao-Yi Tan Lixin ZhangState Key Laboratory of Bioreactor Engineeringand School of BiotechnologyEast China University of Science and Technology(ECUST)Shanghai 200237China State Key Laboratory for Biology of Plant Diseases and Insect PestsInstitute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China State Key Laboratory of Microbial ResourcesInstitute of MicrobiologyChinese Academy of SciencesBeijing 100101China Department of UrologySixth People’s Hospital South Campus Affiliated to Shanghai Jiao Tong UniversityShanghai 201499China Shenzhen Institute of Synthetic BiologyShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China The Novo Nordisk Foundation Center for BiosustainabilityTechnical University of DenmarkKgs Lyngby 2800Denmark University of Chinese Academy of SciencesBeijing 100049China 
Rapid and sensitive detection of various analytes is in high *** from its application in genome editing,CRISPR-Cas also shows promises in nucleic acid detection *** further exploit the potential of CRISPR-Cas for dete...
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鞭毛/纤毛内在驱动机制启发的一体式管状机器人驱动器
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《Engineering》2023年 第4期23卷 170-180,M0008页
作者:苗佳麒 张铁山 李根 郭栋 孙思琦 谭蓉 史家海 申亚京Shenzhen Research Institute of City University of Hong KongShenzhen 515100China Department of Biomedical EngineeringCity University of Hong KongHong Kong 999077China Department of Electronic and Computer EngineeringHong Kong University of Science and TechnologyHong Kong 999077China Cheng Kar-Shun Robotics Institute(CKSRI)Hong Kong University of Science and TechnologyHong Kong 999077China Synthetic Biology Translational Research ProgrammesYong Loo Lin School of MedicineNational University of SingaporeSingapore 119077Singapore Department of BiochemistryYong Loo Lin School of MedicineNational University of SingaporeSingapore 119077Singapore 
鞭毛和纤毛独特的运动模式(如鞭毛的平面/螺旋波形式推进和纤毛的二维/三维不对称搏动)在众多生物的生命活动中起到至关重要的作用,这也启发了诸多仿生设计,尤其对于微型机器人系统。然而,与自然界中微生物能够从统一化的9+2轴丝生物结...
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Multidimensional Optimization of Saccharomyces cerevisiae for Carotenoid Overproduction
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《BioDesign Research》2024年 第1期6卷 20-27页
作者:Jian Fan Yang Zhang Wenhao Li Zhizhen Li Danli Zhang Qiwen Mo Mingfeng Cao Jifeng YuanState Key Laboratory of Cellular Stress BiologySchool of Life SciencesFaculty of Medicine and Life SciencesXiamen UniversityFujian 361102China Shenzhen Research Institute of Xiamen UniversityShenzhen 518057China College of Chemistry and Chemical EngineeringXiamen UniversityFujian 361005China Key Laboratory for Synthetic Biotechnology of Xiamen CityXiamen UniversityFujian 361005China 
Microbial synthesis of carotenoids is a highly desirable alternative to plant extraction and chemical *** this study,we investigated multidimensional strategies to improve the carotenoid synthesis in the industrial wo...
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