摘要：Resource-scarce regions with serious COVID-19 outbreaks do not have enough ventilators to support critically ill patients,and these shortages are especially devastating in developing *** help alleviate this strain,we have designed and tested the accessible low-barrier in vivo-validated economical ventilator(ALIVE Vent),a COVID-19-inspired,cost-effective,open-source,in vivo-validated solution made from commercially available *** ALIVE Vent operates using compressed oxygen and air to drive inspiration,while two solenoid valves ensure one-way flow and precise cycle *** device was functionally tested and profiled using a variable resistance and compliance artificial lung and validated in anesthetized large *** functional test results revealed its effective operation under a wide variety of ventilation conditions defined by the American Association of Respiratory Care guidelines for ventilator *** large animal test showed that our ventilator performed similarly if not better than a standard ventilator in maintaining optimal ventilation *** FiO2,respiratory rate,inspiratory to expiratory time ratio,positive-end expiratory pressure,and peak inspiratory pressure were successfully maintained within normal,clinically validated ranges,and the animals were recovered without any *** regions with limited access to ventilators,the ALIVE Vent can help alleviate shortages,and we have ensured that all used materials are publicly *** this pandemic has elucidated enormous global inequalities in healthcare,innovative,cost-effective solutions aimed at reducing socio-economic barriers,such as the ALIVE Vent,can help enable access to prompt healthcare and life saving technology on a global scale and beyond COVID-19.

摘要：The ability to finely control the structure of protein folds is an important prerequisite to functional protein design. The TIM barrelfold is an important target for these efforts as it is highly enriched for diverse functions in nature. Although a TIM barrel proteinhas been designed de novo, the ability to finely alter the curvature of the central beta barrel and the overall architecture of the foldremains elusive, limiting its utility for functional design. Here, we report the de novo design of a TIM barrel with ovoid (twofold)symmetry, drawing inspiration from natural beta and TIM barrels with ovoid curvature. We use an autoregressive backbonesampling strategy to implement our hypothesis for elongated barrel curvature, followed by an iterative enrichment sequencedesign protocol to obtain sequences which yield a high proportion of successfully folding designs. Designed sequences arehighly stable and fold to the designed barrel curvature as determined by a 2.1Å resolution crystal structure. The designs showrobustness to drastic mutations, retaining high melting temperatures even when multiple charged residues are buried in thehydrophobic core or when the hydrophobic core is ablated to alanine. As a scaffold with a greater capacity for hosting diversehydrogen bonding networks and installation of binding pockets or active sites, the ovoid TIM barrel represents a major steptowards the de novo design of functional TIM barrels.

摘要：Genetically engineered plants hold enormous promise for tackling global food security and agricultural sustainability ***,construction of plant-based genetic circuitry is constrained by a lack of well-characterized genetic parts and circuit design *** contrast,advances in bacterial synthetic biology have yielded a wealth of sensors,actuators,and other tools that can be used to build bacterial *** root-colonizing bacteria(rhizobacteria)exert substantial influence over plant health and growth,genetic circuit design in these microorganisms can be used to indirectly engineer plants and accelerate the design-build-test-learn ***,we outline genetic parts and best practices for designing rhizobacterial circuits,with an emphasis on sensors,actuators,and chassis species that can be used to monitor/control rhizosphere and plant processes.

摘要：The combination of Anti-de Sitter space （AdS） methods with light-front holography leads to a semi-classical first approximation to the spectrum and wavefunctions of meson and baryon light-quark bound *** from the bound-state Hamiltonian equation of motion in QCD,we derive relativistic lightfront wave equations in terms of an invariant impact variable ζ which measures the separation of the quark and gluonic constituents within the hadron at equal light-front *** equations of motion in physical space-time are equivalent to the equations of motion which describe the propagation of spin-J modes in anti–de Sitter （AdS） *** eigenvalues give the hadronic spectrum,and its eigenmodes represent the probability distributions of the hadronic constituents at a given *** to the light meson and baryon spectra are *** predicted meson spectrum has a string-theory Regge form M^ 2 = 4κ ^2 （n＋L＋S/2）;i.e.,the square of the eigenmass is linear in both L and n,where n counts the number of nodes of the wavefunction in the radial variable ζ.The space-like pion and nucleon form factors are also well *** thus obtains a remarkable connection between the description of hadronic modes in AdS space and the Hamiltonian formulation of QCD in physical space-time quantized on the light-front at fixed light-front time τ.The model can be systematically improved by using its complete orthonormal solutions to diagonalize the full QCD lightfront Hamiltonian or by applying the Lippmann-Schwinger method in order to systematically include the QCD interaction terms.

摘要：Light-front holography leads to a rigorous connection between hadronic amplitudes in a higher dimensional anti-de Sitter(AdS) space and frame-independent light-front wavefunctions of hadrons in(3 + 1)-dimensional physical space-time,thus providing a compelling physical interpretation of the AdS/CFT correspondence principle and AdS/QCD,a useful framework which describes the correspondence between theories in a modified AdS 5 background and confining field theories in physical *** a first semiclassical approximation,where quantum loops and quark masses are not included,this approach leads to a single-variable light-front Schro¨dinger equation which determines the eigenspectrum and the light-front wavefunctions of hadrons for general spin and orbital angular *** coordinate z in AdS space is uniquely identified with a Lorentz-invariant coordinate ζ which measures the separation of the constituents within a hadron at equal light-front *** internal structure of hadrons is explicitly introduced and the angular momentum of the constituents plays a key *** give an overview of the light-front holographic approach to strongly coupled *** particular,we study the photon-to-meson transition form factors(TFFs) FMγ(Q 2) for γ→ M using light-front holographic *** results for the TFFs for the η and η ' mesons are also *** novel features of QCD are discussed,including the consequences of confinement for quark and gluon condensates.A method for computing the hadronization of quark and gluon jets at the amplitude level is outlined.

摘要：Hydrogenated 非结晶的 Si (-Si:H) 由于它的低费用，高丰富，长一生，和非毒性是为光电的应用的有希望的材料。我们表明设计在光电的设备在量效率上调查 nanostructured 背反射镜的效果的一台设备。我们采用一种 superstrate 配置以便我们可以使用为比较作为一本参考书为薄电影太阳能电池套住策略的常规工业光。我们经由晶片规模控制了 nanostructure 参数自己组装技术并且系统地学习了在 nanostructure 之间的关系尺寸和光电流产生。在与减少的 nanostructure 规模红移动的显示出的短波长的获得 / 损失转变。在红外线的区域， nanostructured 背反射镜与修改特征规模显示出大光电流改进。这设备几何学是为由 nanostructures 调查吸收改进的一个有用原型。

摘要：为象氢进化反应那样的电气化学的反应的高度活跃、便宜的催化剂(她的) 为有效精力的发展是关键的变换和存储技术。理论模拟在揭示在材料和他们的催化活动的电子结构之间的关联是有帮助的，并且指导改进催化剂的预言和发展。然而，在精确地设计需要的原子地点的困难在做在试验性、理论的结果之间的直接比较导致挑战。在瞬间 2 , 而薹是惰性的，瞬间边被表明了为她活跃。用一条计算基于描述符的途径，我们预言由合并转变金属原子(Fe，公司， Ni，或 Cu ) ，薹地点应该也成为她活跃。垂直地站的、终止边的瞬间 2 nanofilms 为验证这些预言提供一个明确的模型系统。转变金属做了瞬间 2 nanofilms 表演交换水流密度由的增加至少双重，与理论计算一致。这个工作为由把倡导者合并到特别原子地点改进电气化学的催化剂，并且为使用明确的系统以便理解提升效果的起源开创进一步的机会。

摘要：The support for multiple video streams in an ad-hoc wireless network requires appropriate routing and rate allocation measures ascertaining the set of links for transmitting each stream and the encoding rate of the video to be delivered over the chosen links. The routing and rate allocation procedures impact the sustained quality of each video stream measured as the mean squared error (MSE) distortion at the receiver, and the overall network congestion in terms of queuing delay per link. We study the trade-off between these two competing objectives in a convex optimization formulation, and discuss both centralized and dis- tributed solutions for joint routing and rate allocation for multiple streams. For each stream, the optimal allocated rate strikes a balance between the selfish motive of minimizing video distortion and the global good of minimizing network congestions, while the routes are chosen over the least-congested links in the network. In addition to detailed analysis, network simulation results using ns-2 are presented for studying the optimal choice of parameters and to confirm the effectiveness of the proposed measures.

摘要：化学链燃烧(CLC)和化学链重整(CLR)是通过循环氧化还原反应,清洁高效地将烃类转化为动力、燃料和化学品的创新技术。金属氧化物材料在化学链氧化还原过程中起着至关重要的作用。在还原过程中,氧载体为烃类的转化和产物合成提供所需的氧离子量。在氧化步骤中,耗尽的金属氧化物氧载体从空气中补充分子氧,同时释放热量。近年来,用于各种化学链应用的氧载体材料已经取得了较大进展。在这些金属氧化物材料中,铁基氧载体由于其高携氧能力、显著的成本效益,以及化学链反应在实际应用方面的多功能性而具有吸引力。它们的反应性也可以通过结构设计和改性进一步得到增强。本文综述了氧载体材料的发展及其在这些材料上的烃类转化机制的最新进展。这些进展将有助于氧载体材料的开发,以实现更有效的化学链技术应用。

摘要：Cholangiocarcinoma(CCA)is characterized by heterogeneous mutations and a refractory ***,the development of a model for effective drug screening is urgently *** the established therapeutic testing models for CCA are often ineffective,we fabricated an enabling three-dimensional(3D)-bioprinted CCA-on-a-chip model that to a good extent resembled the multicellular microenvironment and the anatomical microstructure of the hepato-vascular-biliary system to perform high-content antitumor drug ***,cholangiocytes,hepatocytes,and vascular endotheliocytes were employed for 3D bioprinting of the models,allowing for a high degree of spatial and tube-like microstructural ***,it was possible to observe CCA cells attached to the surfaces of the gelatin methacryloyl(GelMA)hydrogelembedded microchannels and overgrown in a thickening manner,generating bile duct stenosis,which was expected to be analogous to the in vivo *** 4000 differentially expressed genes were detected in the CCA cells in our 3D coculture model compared to the traditional two-dimensional(2D)*** screening revealed that the CCA cells grown in the 3D traditional model were more sensitive to the antitumoral prodrug than those in the 2D monoculture due to drug biotransformation by the neighboring functional *** study provides proof-of-concept validation of our bioprinted CCA-on-a-chip as a promising drug screening model for CCA treatment and paves the way for potential personalized medicine strategies for CCA patients in the future.