摘要：A numerical model was established to predict and optimise the chemical cleaning process of Polyvinylidene Fluoride(PVDF)Ultra filtration(UF)membranes with the results from the experiment that applied the Response Surface Method(RSM)and Central Composite design(CCD).The factors considered in the experimental design were sodium hydroxide(NaOH)concentration,sodium hypochlorite concentration(NaClO),citric acid concentration and cleaning *** interactions between the factors were investigated with the numerical *** acid(20 mg·L-1)was used as the model foulant,and chemical enhanced back flush(CEB)was employed to simulate the chemical cleaning *** concentrations of sodium hydroxide,sodium hypochlorite,citric acid and cleaning duration tested during the experiments were in the range of 0.1%–0.3%,100–300 mg·L-1,1%–3%and 0.5–1.5 h,*** the variables,the sodium hypochlorite concentration and the cleaning duration showed a positive relationship involving the increased ef ficiency of the chemical *** chemical cleaning ef ficiency was hardly improved with increasing concentrations of sodium ***,the data was sharply decreased when at a low level of sodium hydroxide *** total,54 sets of cleaning schemes with 80%to 100%cleaning ef ficiency were observed with the RSM model after calibration.