摘要：Three-dimensional(3D)printing has attracted increasing research interest as an emerging manufacturing technology for devel-oping sophisticated and exquisite architecture through hierarchical *** has also been employed in various advanced industrial *** development of intelligent biomedical engineering has raised the requirements for 3D printing,such as flexible manufacturing processes and technologies,biocompatible constituents,and alternative ***,state-of-the-art 3D printing mainly involves inorganics or polymers and generally focuses on traditional industrial fields,thus severely limiting applications demanding biocompatibility and *** this regard,peptide architectonics,which are self-assembled by programmed amino acid sequences that can be flexibly functionalized,have shown promising potential as bioinspired inks for 3D ***,the combination of 3D printing and peptide self-assembly poten-tially opens up an alternative avenue of 3D bioprinting for diverse advanced ***,a small but innovative nation,has significantly contributed to 3D bioprinting in terms of scientific studies,marketization,and peptide architectonics,including modulations and applications,and ranks as a leading area in the 3D bioprinting *** review summarizes the recent progress in 3D bioprinting in Israel,focusing on scientific studies on printable components,soft devices,and tissue *** paper further delves into the manufacture of industrial products,such as artificial meats and bioinspired supramolecular architectures,and the mechanisms,physicochemical properties,and applications of peptide ***,Israel contributes significantly to the field of 3D bioprinting and should thus be appropriately recognized.

摘要：Extrusion-based cell deposition has become a prominent technique for expanding bioprinting ***,the associated print resolution in the order of nanolitre or above has been a limiting *** demand for improving print resolution towards the scale of a single cell has driven the development of precision nozzle extrusion,although the benefits gained remain ***,aided by in situ imaging,we investigated the dynamics of cell organisation through an extrusion-based microcapillary tip with picolitre precision through in-air or immersion *** microcapillary extrusion setup,termed‘Picodis’,was demonstrated by generating droplets of colouring inks immersed in an immiscible ***,using 3T3 fibroblast cells as an experimental model,we demonstrated the deposition of cell suspension,and pre-aggregated cell ***,the dynamic organisation of cells within the microcapillary tip was described,along with cell ejection and deposition upon exiting the tip *** vision-assisted approach revealed that when dispersed in a culture medium,the movements of cells were distinctive based on the flow profiles and were purely driven by laminar fluid flow within a narrow *** primary process limitations were cell sedimentation,aggregation and compaction,along with trapped air *** use of picolitre-level resolution microcapillary extrusion,although it provides some level of control for a small number of cells,does not necessarily offer a reliable method when a specified number of cells are *** study provides insights into the process limitations of high-resolution cell ink extrusion,which may be useful for optimising biofabrication processes of cell-laden constructs for biomedical research.

摘要：通过两电子氧化还原反应(2e^(-)ORR)原位分散生产过氧化氢(H_(2)O_(2))是一种很有前途的、能替代传统的能源密集型蒽醌法的过氧化氢生产方法.然而,其实际应用高度依赖于高活性、高选择性的两电子氧还原电催化剂的设计与合成,并且仍面临挑战.本文利用生物质材料细菌纤维素调控合成金属镍纳米颗粒,通过简单的浸渍-热解法得到锚定在细菌纤维素衍生的碳纤维上的镍纳米颗粒催化剂.通过调控镍前驱体的用量,发现Ni-NPs/BCCF-20.7催化剂具有优异的两电子氧化还原催化性能,其表现出~90%的H_(2)O_(2)选择性且起始电位为0.75 V(相对于可逆氢电极(RHE)).通过H-Cell恒电位电解,该催化剂分别在0.2和0.5 V(相对于RHE)得到最高的H_(2)O_(2)生成速率(162.7±13.7 mmol gcat^(-1)h^(-1))和法拉第效率(93.9%±4.2%).进一步理论计算表明,氧气分子在暴露的Ni(111)晶面上具有更有利的"垂直"吸附构型,可以有效抑制O–O键的解离,从而具有较高的H_(2)O_(2)选择性.

摘要：房颤是人类健康的“隐形杀手”,常诱发心肌梗塞、中风、心力衰竭等高危疾病.幸运的是,房颤可以早期诊断和治疗.低水平迷走神经刺激(LL-VNS)是一种很有前途的房颤治疗方法.然而,其在生物电刺激装置的灵活性、小型化和长期服务方面仍需要克服很多问题.为此,本文设计了一个闭环自供电LL-VNS系统,可以实时监测患者的脉搏波,并在房颤发生时自动传输刺激的脉冲.该植入物是一种复合式纳米发电机(H-NG),其特点是柔性、便携且不需要电路元件和电池.H-NG的最大输出为14.8 V和17.8μA(峰-峰值).体内的效果验证结果表明,LL-VNS治疗后房颤持续时间显著降低90%,而且心肌纤维化和心房连接蛋白水平得到有效改善.值得注意的是,在该治疗系统中观察到通过介导NF-κB和AP-1途径而触发的抗炎作用.总体而言,这种植入式生物电子设备有望用于慢性病的自供电、智能化、便携式的管理和治疗.

摘要：压电半导体具有压电效应和半导体电学特性,可以用于压电电子学器件和压电光电子学器件.压电电子学器件和压电光电子学器件利用外加应变产生的压电电荷调控压电电子学pn结、金属半导体(M-S)接触的载流子传输、分离、复合等过程.压电电子学器件具有灵敏度高、响应速度快和功耗超低的优点,非常适合在自驱动系统中应用,因此在物联网、可穿戴系统、植入式传感系统具有巨大的应用价值.压电电荷的分布宽度能够显著影响压电电子学器件的传感性能,是压电电子学器件重要参数之一.压电电荷的分布宽度则可以通过压电电子学器件的电容电压(C-V)特性获得.本文以压电电子学金属-绝缘体-半导体(MIS)晶体管为例,提出对压电电荷分布影响进行测量和计算的理论模型,并进行了数值模拟,为以C-V测量为基础的结区压电电荷分布宽度实验设计给出了可行的理论方案.