摘要：As the Chinese Lunar New Year-Spring Festival 2025 begins,we take an opportunity to look back at the journal Bio-Design and manufacturing(BDM for short).The journal BDM,first published in 2018,is related not only to human life and health but also to the frontier disciplines of global scientific and technological *** we highlight a few points of interest from the past year in order to encourage more readers to pay attention to this exciting field.

摘要：Deformation control of 4D printing has always been ***,a design method for the fiber trajectory for 4D printing composite structures with embedded continuous fibers is reported,wherein the designed composite structures can be deformed into many types of deployable *** of the bilayer composite structure was driven by differences in the coefficients of thermal expansion(CTEs)between the resin substrate and embedded *** bending curvature and direction of the composite structure is controlled by adjusting fiber *** to differential geometry theory,the relationship between the angle of intersecting fiber bundles and curvature of the final shape was ***,arbitrary deployable surfaces,including conical,cylindrical,and tangent surfaces,can be *** design and additive manufacturing strategy allow precise control of the deforming process,greatly extending the potential applications of 4D printing.

摘要：This study proposes a new topology optimization solution providing designers with choices for feasible stiffener layouts inside large-scale containers of garbage trucks. Firstly, the mathematical expressions of loading conditions inside garbage containers are derived. Then, a growth-based layout optimization framework is built, taking inspiration from the morphology of plant ramifications. The principles of the highly effective but individual design rules of existent leaf venation layout problems are explored and transferred into analytical laws. Based on this, an evolutionary algorithm is developed to simulate the load-adapted growth of stiffener layouts, which provides an approximately homogeneous stress distribution along the surface of self-optimizing structures, Unlike the conventional methods, the new approach needs neither the densest ground structure nor the modification of the existing finite element programs, it is fast, easy to apply and nearly constraint free. Finally, a case study is provided showing how a large-scale container structure can be designed by this extremely intelligent CAD approach.

摘要：Biomaterial scaffolds play an important role in maintaining the viability and biological functions of highly metabolic hepatocytes in liver tissue engineering. One of the major challenges involves building a complex microchannel network inside three-dimensional （3D） scaffolds for efficient mass transportation. Here we presented a biomimetic strategy to generate a mi- crochannel network within porous biomaterial scaffolds by mimicking the vascular tree of rat liver. The typical parameters of the blood vessels were incorporated into the biomimetic design of the microchannel network such as branching angle and diameter. Silk fibroin-gelatin scaffolds with biomimetic vascular tree were fabricated by combining micromolding, freeze drying and 3D rolling techniques. The relationship between the micro-channeled design and flow pattern was revealed by a flow experiment, which indicated that the scaffolds with biomimetic vascular tree exhibited unique capability in improving mass transportation inside the 3D scaffold. The 3D scaffolds, preseeded with primary hepatocytes, were dynamically cultured in a bioreactor system. The results confirmed that the pre-designed biomimetic microchannel network facilitated the generation and expansion of hepatocytes.

摘要：Bioprinting has been widely investigated for tissue engineering and regenerative medicine ***,it is still difficult to reconstruct the complex native cell arrangement due to the limited printing resolution of conventional bioprinting techniques such as extrusion-and inkjet-based ***,an electrohydrodynamic(EHD)bioprinting strategy was reported for the precise deposition of well-organized cell-laden constructs with microscale filament size,whereas few studies have been devoted to developing bioinks that can be applied for EHD bioprinting and simultaneously support cell *** study describes functionalized alginate-based bioinks for microscale EHD bioprinting using peptide grafting and fibrin incorporation,which leads to high cell viability(>90%)and cell *** printed filaments can be further refined to as small as 30μm by incorporating polyoxyethylene and remained stable over one week when exposed to an aqueous *** utilizing the presented alginate-based bioinks,layer-specific cell alignment along the printing struts could be observed inside the EHD-printed microscale filaments,which allows fabricating living constructs with cell-scale filament resolution for guided cellular orientation.

摘要：The modular design technology is of importance increasingly,as product structure is more and more *** design systems face challenging problems as the design information tends to be dynamic,redundant,and very *** paper describes a novel approach for handling *** this approach,a partition is firstly performed for the complex structural components by mapping functions to the structures layer by *** on this partition,a comprehensive design matrix is then developed to identify the key design mode which is driven by a special *** design process is also programmed by analyzing the coupled information on both the functional and structural ***,the integrated knowledge model based on object-oriented method and hybrid inference method is *** this model,knowledge can be organized at hierarchical classification and expressed with different ***,the methodology developed has been applied to a real application in automobile cylinder block design and the results are presented.

摘要：目的:振动在机械结构的工作中难以避免,且会显著降低机械结构的工作性能。因此,结构动力响应优化设计就显得尤为重要。本文旨在提出一种有效的简谐力激励下的结构拓扑优化方法,通过合理设计结构内加强筋的布局,减小结构特定位置处的位移响应幅值,提高结构的固有频率。概要:植物叶脉可以有效地支撑叶片以抵抗自然界中的风载。本文将植物叶脉分叉构型的最优性用于简谐力激励下结构的加强筋布局设计。首先对简谐力激励下结构的位移响应进行分析。在此基础上,构建以最小化结构特定位置处位移响应幅值为目标的生长式拓扑优化模型。然后,从数学优化的角度,分析加强筋的生长应遵循的规律,提出生长式拓扑优化的数值实现算法。最后通过数值算例证明了本文所提方法的有效性。

摘要：Microfluidic device with patterned microstructures on the substrate surface was used to regulate cell adhesion,morphology,and functions in tissue *** developed a microfluidic device which employing microscale patterned microstructures to achieve enhanced cell adhesion and *** hydrogel substrates with micro-wavy and lattice-patterned microstructures were fabricated using standing surface acoustic waves and ultraviolet *** seeding the L929 mouse fibroblast cells onto the patterned substrate of the microfluidic device,we determined that the viability and proliferation rate of cell migration can be greatly ***,L929 cells showed two types of gathering modes after 48 h of *** growth was guided by the patterned substrate used in the microfluidic device and showed differences in the location ***,the developed microfluidic device with patterned microstructures can extend the application of in vitro cell culturing for future drug development and disease diagnosis.

摘要：Lancet needle, having three planes at the tip to generate a sharp lancet point, is the most common needle tip geometry and used for medical procedures. This research presents two five-plane lancet needle designs, the five-plane lancet needle with two back bevels （FLN-B） and five-plane lancet needle with two front bevels （FLN-F）, to study the effects of two additional bevel planes on the reduction of soft tissue cutting force. Mathematical models to calculate the inclination angle and rake angle along the cutting edges of FLN-B and FLN-F are developed. By using the grinding process, the prototype FLN-B and FLN-F needles are fabricated. And their inclination and rake angles along the cutting edges are investigated and compared to that of regular lancet needle. Needles insertion tests were conducted on soft PVC phantom which mimics the soft tissue. The initial peak insertion force and steady-state cutting force during needle insertion were identified, and the effect of cutting edge on needle soft tissue cutting force was studied. Compared to lancet needle, FLN-B and FLN-F both have higher inclination and rake angles at the tip cutting edge, could reduce the initial peak needle insertion force and tissue cutting forces, and thus can efficiently cut the soft tissue for medical applications.

摘要：This report provides a highlight of the third International Conference on Biomaterials,Bio-Design and manufacturing(BDMC2023).BDMC2023,based on the journal of Bio-Design and manufacturing(BDM)founded by Zhejiang University,was successfully held in Singapore on August 6–8,2023.