摘要：Autograft or metal implants are routinely used in skeletal ***,they fail to provide long-term clinical resolution,necessitating a functional biomimetic tissue engineering *** use of native human bone tissue for synthesizing a biomimeticmaterial inkfor three-dimensional(3D)bioprintingof skeletal tissueis anattractivestrategyfor ***,human bone extracellular matrix(bone-ECM)offers an exciting potential for the development of an appropriate microenvironment for human bone marrow stromal cells(HBMSCs)to proliferate and differentiate along the osteogenic *** this study,we engineered a novel material ink(LAB)by blending human bone-ECM(B)with nanoclay(L,Laponite®)and alginate(A)polymers using extrusion-based *** inclusion of the nanofiller and polymeric material increased the rheology,printability,and drug retention properties and,critically,the preservation of HBMSCs viability upon *** composite of human bone-ECM-based 3D constructs containing vascular endothelial growth factor(VEGF)enhanced vascularization after implantation in an ex vivo chick chorioallantoic membrane(CAM)*** inclusion of bone morphogenetic protein-2(BMP-2)with the HBMSCs further enhanced vascularization and mineralization after only seven *** study demonstrates the synergistic combination of nanoclay with biomimetic materials(alginate and bone-ECM)to support the formation of osteogenic tissue both in vitro and ex vivo and offers a promising novel 3D bioprinting approach to personalized skeletal tissue repair.

摘要：5-aminosalicylic acid(5-ASA)compounds are a highly effective treatment for ulcerative colitis(UC).While UC patient compliance in clinical studies is over 90%, only 40%of patients in every day life take their prescribed *** to medication has been emphasized recently by a Cochrane meta-analysis that has suggested that future trials of 5-ASA in UC should look at patient compliance rather than drug efficacy. Better compliance can be obtained by reducing the number of tablets and times of *** that the 5-ASA formulations have different delivery systems that split the active moiety in various regions of the intestine,it is particularly important that an adequate dose of the drug arrives at the inflamed part of the colon.5-ASA Multi matrix(MMx)is a novel,high strength(1.2 g),oral formulation designed for oncedaily *** releases the active moiety throughout the *** studies with this compound have shown that it is as effective as 5-ASA enema in the treatment of mild-to-moderate,left-sided UC,and is comparable to a pH-dependent,delayed release 5-ASA (Asacol ),even if given once ***,the effectiveness in the acute phase of UC has been confirmed also in *** conclusion,at present,5-ASA MMx seems theoretically the best agent for maintaining patient compliance,and consequently,treatment effectiveness.

摘要：In this paper the authors describe the design, prototyping and evaluation of SIMpliLife, a framework for mobile phones with the aim of making people’s life easier, providing day-to-day services such as payment, ticketing and information retrieval by means of NFC (Near Field Communication) technology. It was developed via the collaboration between two research labs of Sapienza university of rome: the RFID (Radio Frequency Identification) Lab and the Usability and Accessibility Lab (LUA), both belonging to CATTID (Centre for Applications of Teleservices and of Technologies for Innovation in Digital world) research centre. Technically, SIMpliLife is a SIM-based platform for NFC mobile phones that interfaces several applications able to manage the abovementioned services. The high-level User Interface has been developed by means of Smart Card Web Server (SCWS) technology, thus providing enhanced user experience if compared to traditional SIM-based implementations based on SIM Toolkit.

摘要：Virginia Woolf’s seventh novel,The Waves,first published by the Hogarth Press in 1931,is widely regarded as her most experimental piece of *** complex and elusive structure of the work,the least representational among Woolf’s novels,challenges the reader’s assumptions about the inner and the outer *** the absence of a substantial story,of a convincing plot and well-defined characters,the reader is called upon to search for a deeper coherence and more profound ***,in The Waves the modernist writer strives for a fresh way of expressing a vision of wholeness in a broken *** present article attempts to reread Woolf’s self-conscious novel in the double perspective of separation and reunion,of dispersal and recomposition.A close reading of selected passages will show how the poetics of fragmentation and the poetics of wholeness coexist in Woolf’s narrative,pervading the imagery and the symbols of the *** more than one sense,the dialectic between division and unity,fragmentation and wholeness can be identified as the structuring force of the novel;most tellingly,this textual dynamism is reflected in the oscillatory motion of the waves,continuously breaking and merging.

摘要：The research presented in this paper deals with the seismic protection of existing frame structures by means of passive energy dissipation. An iterative displacement-based procedure, based on capacity spectrum, to design dissipative bracings for seismic retrofitting of the frame structures is described, and some applications are discussed. The procedure can be used with any typology of dissipative device and for different performance targets. In this work, the procedure has been applied, with both traditional pushover (load profile proportional to first mode) and multimodal pushover, to an existing RC (reinforced concrete) frame building. In the application, the buckling restrained braces have been used in order to prevent damages to both the structure and non structural elements. The use of multimodal pushover proves to be more effective than pushover based on single mode in case of medium rise RC frame building (higher than 30 m) but, once this building is retrofitted, and therefore regularized, with a bracing system, the difference between using monomodal or multimodal pushover becomes insignificant.

摘要：斯蒂凡诺·乔凡诺尼是当今世界最为著名的设计师之一,他设计的产品并非为了体现社会地位、品味和功用性。他只是想让他的产品使用简单,并希望它们可以贴心备至,给人们带来愉悦和满足感。早餐或午餐时,人们做烹饪以及处理其他事情的时候所需要用到的东西都已经被考虑了进来,情感的纽带瞬间就在使用者与产品间建立了起来。

摘要：可编程逻辑器件为数字设计中复杂功能的实现提供了一种流行的方法。虽然制造商尚未提供能与VLSI数字电路复杂性相比拟的模拟电路。但现场可编程模拟电路正在信号调整和滤波应用中获得广泛采用。这些器件基于CMOS跨导及开关式电容放大器．可为相对复杂的设计问题提供一种便利的解决方案。Lattice半导体公司（***）的ispPAC10在系统可编程模拟电路．及其附带的PAC Designer软件为电路设计与验证提供了一种方便的方法。本设计实例描述了采用ispPAC10的两款简单正弦波振荡器。

摘要：可以用带有ADC的微控制器设计一个双线加接地组成的键盘接口。例如．可以用一个电阻分压器判定一个按下的键（参考文献1）。微控制器的整合ADC，其输入电阻一般在数百千欧量级．为了有足够的精度，键盘分压器应该具有相对较低电阻值．一般为数十千欧量级。但是．在电池供电系统中，电阻分压器会消耗数百毫安电流，这迫使设计者选择经典的数字矩阵开关和多条I／O线作替代。此外，便携设备设计通常也限制了元件的数量。

摘要：虽然对制动器尖叫声的研究已超过一个多世纪,但仍未找到有效对它抑制的方法。科学界一致认为尖叫声是由于转子模式和衬片模式的耦合造成的,商业制动器的复杂性表明有效解决这个问题的设计方面的障碍。为此,一些研究人员着重于显示类似不稳定性的杆与盘的研究。本文基于伪消声原理推荐一种被动消声器,对杆与盘完全抑制尖叫声的发生。