摘要：Ensuring a sufficient oxygen supply is pivotal for the success of bioprinting applications since it fosters tissue integration and natural *** in oxygen concentration among diverse tissues necessitates the precise recreation of tissue-specific oxygen levels in imprinted constructs to support the survival of targeted *** oxygen-releasing biomaterials,such as oxygen-generating microparticles(OMPs),have shown promise for enhancing the oxygen supply of microenvironments in injured tissues,whether this approach is scalable for large tissues and whether tissue-specific bioinks with varying OMP concentrations remain printable remain *** study addresses this critical gap by introducing an innovative class of engineered oxygenated bioinks that combine colloidal-based microgels with *** report that incorporating nanosized calcium peroxide(nCaO_(2))and manganese oxide nanosheets(nMnO_(2))into hydrophobic polymeric microparticles enables precise modulation of oxygen release while controlling hydrogen peroxide ***,the fabrication of oxygenating and cytocompatible colloidal gels is achieved using an aqueous two-phase *** study thoroughly evaluates the fundamental characteristics of the resulting bioink,including its rheological behaviors,printability,shape fidelity,mechanical properties,and oxygen release ***,this study demonstrates the macroscopic scalability and cytocompatibility of printed constructs produced via cell-laden oxygenating colloidal *** showcasing the effectiveness of extrusion-based bioprinting,this study underscores how it can be used to fabricate biomimetic tissues,indicating its potential for new *** findings presented here advance the bioprinting field by achieving scalability with both high cell viability and the possibility of mimicking specifically oxygenated *** work thereby offers a promising avenue for the development of functional tissues with e

摘要：Since the start of the Precision Medicine Initiative by the United States of America in 2015,interest in personalized medicine has grown *** short,personalized medicine is a term that describes medical treatment that is tuned to the *** possible way to realize personalized medicine is 3D *** using materials that can be tuned upon stimulation,4D printing is *** recent years,many studies have been exploring a new field that combines 3D and 4D printing with *** has resulted in many concepts of pharmaceutical devices and formulations that can be printed and,possibly,tailored to an ***,the first 3D printed drug,Spritam®,has already found its way to the *** review gives an overview of various 3D and 4D printing techniques and their applications in the pharmaceutical field as drug delivery systems and personalized medicine.

摘要：Currently,artificial-membrane lungs consist of thousands of hollow fiber membranes where blood flows around the fibers and gas flows inside the fibers,achieving diffusive gas *** both ends of the fibers,the interspaces between the hollow fiber membranes and the plastic housing are filled with glue to separate the gas from the blood *** a uniaxial centrifugation process,the glue forms the“potting.”The shape of the cured potting is then determined by the centrifugation process,limiting design possibilities and leading to unfavorable stagnation zones associated with blood *** this study,a new multiaxial centrifugation process was developed,expanding the possible shapes of the potting and allowing for completely new module designs with potentially superior blood flow guidance within the potting ***-phase simulations of the process in conceptual artificial lungs were performed to explore the possibilities of a biaxial centrifugation process and determine suitable parameter sets.A corresponding biaxial centrifugation setup was built to prove feasibility and experimentally validate four conceptual designs,resulting in good agreement with the *** summary,this study shows the feasibility of a multiaxial centrifugation process allowing greater variety in potting shapes,eliminating inefficient stagnation zones and more favorable blood flow conditions in artificial lungs.

摘要：什么时候以及为什么现代主义过时了20世纪70年代的知识文化风潮与60年代形成了鲜明的对比。在60年代,＂让世界变得更好＂的理想在社会的每个角落都非常盛行,人们普遍认为,未来天堂在人间实现的唯一可能借助的力量就是现代技术。

摘要：Designing technologies is a process that relies on multiple interactions between design and use contexts. These interactions are essential to the development and establishment of technologies. This article seeks to understand the attempts of healthcare organisations to integrate use contexts into the design of healthcare technologies following insights of the theoretical approaches of social learning and user representations. We present a multiple case study of three healthcare technologies involved in improving elderly care practice. These cases were part of a Dutch quality improvement collaborative program, which urged that development of these technologies was not “just” development, but should occur in close collaboration with other parts of the collaborative program, which were more focused on implementation. These cases illustrate different ways to develop technologies in interaction with use contexts and users. Despite the infrastructure of the collaborative program, interactions were not without problems. We conclude by arguing that interactions between design and use are not naturally occurring phenomena, but must be actively organised in order to create effects.

摘要：Many problems with underlying variational structure involve a coupling of volume with surface effects.A straight-forward approach in a finite element discretiza- tion is to make use of the surface triangulation that is naturally induced by the volume *** an adaptive method one wants to facilitate'matching'local mesh modifications,i.e.,local refinement and/or coarsening,of volume and surface mesh with standard tools such that the surface grid is always induced by the volume grid. We describe the concepts behind this approach for bisectional refinement and describe new tools incorporated in the finite element toolbox *** also present several important applications of the mesh coupling.

摘要：药物设计是药品生命周期的起始阶段,也是控制药品风险的关键环节。纳米药物设计是实现风险控制的"源头"治理,设计过程采用的价值敏感设计(价值嵌入)方法是设计者负责任创新意识的展现。由纳米制剂的结构效应和尺寸效应客观决定的纳米药物设计者责任,不仅表现为对纳米药物风险的技术评估(TA)的责任,而且需要从建构论视角探索纳米药物风险的建构性技术评估(CTA)体系。建构性纳米药物风险评估的理论基础是马克思主义的"人本"理论和利益相关者理论。纳米药物设计者实施负责任创新的路径应关注知识提升、道德规范、法律制约及政策导向4个维度。

摘要：Road throughput can be increased by driving at small inter-vehicle time gaps. The amplification of velocity disturbances in upstream direction, however, poses limitations to the minimum feasible time gap. This effect is covered by the notion of string stability. String-stable behavior is thus considered an essential requirement for the design of automatic distance control systems, which are needed to allow for safe driving at time gaps well below 1 s. Using wireless inter-vehicle communications to provide real-time information of the preceding vehicle, in addition to the information obtained by common Adaptive Cruise Control （ACC） sensors, appears to significantly decrease the feasible time gap, which is shown by practical experiments with a test fleet consisting of six passenger vehicles. The large-scale deployment of this system, known as Cooperative ACC （CACC）, however, poses challenges with respect to the reliability of the wireless communication system. A solution for this scalability problem can be found in decreasing the transmission power and/or beaconing rate, or adapting the communications protocol. Although the main CACC objective is to increase road throughput, the first commercial application of CACC is foreseen to be in truck platooning, since short distance following is expected to yield significant fuel savings in this case.

摘要：针对IEEE 802.11n无线网络中的速率、MIMO模式与信道宽度的联合自适应问题,提出了一种基于非静态Multi-Armed Bandit学习方法的联合自适应算法,并设计了一种新颖的报酬函数.为解决该算法收敛时间较慢的问题,基于分类回归树设计了MCS、MIMO模式以及信道宽度预测算法,其能够有效利用无线网卡驱动程序采集的相关统计数据预测不同MCS、MIMO模式以及信道宽度组合的报酬函数,大幅度缩小联合自适应算法的搜索空间.该算法具有易实现、近似最优及计算复杂度低的特点.真实实验结果表明:在无干扰和不同干扰环境下,联合自适应算法都能够有效地提高UDP吞吐量.

摘要：信息时代的到来使得高等教育体系中学习和工作的紧密联系越发显现出来。合作教育体系以及基于工作的学习,是实现工学结合的有效手段,在这个体系中,学校和企业紧密合作,学生将学习和工作有机结合。为了探究合作高等教育的发展动因及其阻碍因素,围绕合作教育的评价体系和有关政策,进行了大量的调研和分析。为了推进合作教育体系观念的认可,对高等职业院校和多家企业参与者的合作进行了调研和督察。这种独特的高等教育理念的推广,需要建立质量保证体系来明确人才培养标准和学生如何达到这些标准,还需要清晰描述所涉及各方的责任和义务。高等教育部门和企业参与合作课程的设计,对于双方持续校企合作的建立和发展是非常有帮助的,但还需要克服两者之间文化的差异。