摘要：Brain tumors’severity ranges from benign to highly aggressive and *** tools can assist in understanding the pathophysiology of these tumors from outside the body and facilitate development of suitable antitumoral ***,we first describe the physiology and cellular composition of brain ***,we discuss the development of threedimensional tissue models utilizing brain tumor *** particular,we highlight the role of hydrogels in providing a biomimetic support for the cells to grow into defined *** technologies,such as electrospinning and bioprinting,and advanced cellular models aim to mimic the extracellular matrix and natural cellular localization in engineered tumor ***,we review current applications and prospects of hydrogels for therapeutic purposes,such as drug delivery and co-administration with other *** further development,hydrogels can serve as a reliable option for in vitro modeling and treatment of brain tumors for translational medicine.

摘要：研究目标是建立通用的纳米级表面涂层技术, 修改粗糙的钛表面化学牙种植体,同时保持微米级水平的表面形貌。以表面形貌调控表面化学,可能会引起生物活性、加速植入种植体表面的整合、缩短移植后的愈合时间。羟基磷灰石(HA)具有生物相容性和骨传导材料特点,HA 涂层具有促进骨骼生长的优点,但涂层易脱落,有混合晶相弊端。本文介绍了凯美特(Chemat)公司的一项新技术(BioFun),即设计一种新型室温自组装,在粗糙度为微米级水平的植体表面来制备纳米级促进骨生长表面。表面经过发射扫描电镜,X 射线光电子能谱,EDS 和 SMM 分析得到表征。生物相容性和生物植入物的表面活性研究在动物体外和体内进行。在动物体外,大鼠骨髓基质干细胞培养试验表明新型植体表面技术是生物相容的,也是无毒的。纳米羟基磷灰石植入已通过官能 10993 生物相容性面板测试。实验植入物或无 HA 纳米粒子的手术放置在植入大鼠股骨和推入式测试后 2 个星期愈合。这些数据表明,HA 纳米粒子沉积加速早期骨整合的过程,可能增加其剪切粘结强度。总之,BioFun 技术可创建一个纳米尺度的成骨表面,HA 纳米颗粒沉积并没有改变钛基板的预期微观形貌,而创造了新的纳米级形貌,这明显有利于加速骨植入的融合。