摘要：Inspired by the intriguing structures and remarkable activities of sesquiterpenoid dimers,12 new sesquiterpenoid dimers,artematrovirenolides A—D(1—4)and artematrolides S—Z(8—12),were isolated from the EtOAc fraction of Artemisia atrovirens through a bioactivity-guided *** structures were elucidated by comprehensive spectroscopic data and absolute configuration was assigned based on single crystal X-ray diffraction data and ECD ***,all compounds are presumably formed via[4+2]cycloaddition involving three connecting *** 1—4 are four novel hetero-dimeric[4+2]Diels-Alder adducts dimerized from a rotundane-type unit and a guaiane-type monomer,and compounds 5—12 are eight new homo-dimeric[4+2]adducts derived from two guaianolide moieties.A putative biosynthetic pathway for compounds 1—4 was also *** 4,6,7,and 10 demonstrated moderate cytotoxicity against HepG2,SMMC-7721,and Huh7 cell lines with IC50 values ranging from 9.3 to 62.3μmol/***,compounds 5 and 11 manifested cytotoxicity with IC50 values of 13.6 and 12.8(HepG2),18.5 and 13.1(SMMC-7721),and 16.5 and 19.4μmol/L(Huh7),respectively,which were equivalent to the positive control,*** investigation suggests that compounds 5 and 11 might be considered as potent antihepatoma candidates and deserve further structural modification and mechanism study.

摘要：Main observation and conclusion An HPLC-UV-guided separation was performed and four pairs of unprecedented macathiohydantoin dimers,lepithiohydimerins A—D(1—4)bearing a rare disulfide bond were isolated from the tubers of *** structures were unambiguously confirmed by NMR spectroscopic,X-ray crystallographic and electronic circular dichroism(ECD)*** the concentration of 20μmol/L,compounds 2-1,2-2,and 4-1 increased the viability of PC12 cells with the cell viability at(72.06±1.14)%,(72.64±1.49)%,and(70.93±1.22)%,***,the serial concentration experiment showed that they can protect PC12 cells in a dose-dependent manner.

摘要：Topology,as a geometrical branch,studies spaces,whose essence lies in its topological *** far as literary criticism is concerned,the author’s writing purpose can be regarded as an open set in topology,which contains a number of different topological *** matter how these spaces transform,they remain fundamental properties as long as their essence is *** the perspective of topology,Shakespeare constructed three equivalent metaphorical topological spaces:one-pound-flesh agreement,marriage casket“lottery”,and wedding ring *** present paper purports to explore how Shakespeare constructed the three equivalent topological spaces to express the theme of literature:the ubi sunt1 motif of life philosophy.

摘要：Juliet,Portia and Cordelia are three heroines in plays of King Lear,Romeo and Juliet and The Merchant of Venice written by *** they are endowed with various personalities,the three women have all shown a brave trait in their character,which makes them become the representatives of brave *** and equivalence are two important terms used to describe the deduction of topological *** a topological perspective,the thesis purports to study and interpret the distinctive and vivid artistic images of Juliet,Portia and Cordelia,finding that their diverse artistic images and similar bravery are in response to the transformation and equivalence in literary metaphorical topological *** helps to explain the reason why Shakespeare had created so many colorful female *** this sense,this paper provides a new point of view and a new mechanism to interpret Shakespeare’s plays.

摘要：在综合分析相关评价模型的基础上,本论文探讨了地质公园阐释系统的评价体系和评价模型。主要步骤如下:(1)构建指标体系。综合运用理论方法、频率法和专家咨询法,本论文构建了地质公园阐释系统评价指标体系。评价指标体系包括3个一级指标、8个二级指标和30个三级指标。(2)确定指标权重和评分标准。本论文采用层次分析法确定评价指标体系中各指标的权重,明确了各指标的测量方法和评分标准。(3)建立评价模型和评价等级。本论文构建了阐释系统开发评价模型,并根据评价结果划分了四个评价等级。(4)实证研究。利用评价指标体系和评价模型,本论文对苍山世界地质公园阐释系统的各项指标进行了测量和调查,然后研究计算每个指标的得分和整个阐释系统的最终得分。评价结果表明,各层次指标得分差异显著。阐释系统总分为7.8854分,表明苍山世界地质公园阐释系统的评价水平较高。针对得分较低的指标,本论文提出了相应的改进对策。

摘要：We describe the footprint and input catalog for bright nights in the LAMOST Pilot Survey, which began in October 2011. Targets are selected from two stripes in the north and south Galactic Cap regions, centered at δ = 29°, with 10° width in declination, covering right ascensions of 135° to 290° and -30° to 30° re- spectively. We selected spectroscopic targets from a combination of the SDSS and 2MASS point source catalogs. The catalog of stars defining the field centers （as re- quired by the Shack-Hartmann wavefront sensor at the center of the LAMOST field） consists of all V 〈 8m stars from the Hipparcos catalog. We employ a statistical selection algorithm that assigns priorities to targets based on their positions in mul- tidimensional color/magnitude space. This scheme overemphasizes rare objects and de-emphasizes more populated regions of magnitude and color phase space, while en- suring a smooth, well-understood selection function. A demonstration of plate design is presented based on the Shack-Hartmann star catalog and an input catalog that was generated by our target selection routines.