摘要：Semiconductor technology and packaging is advancing rapidly toward system integration where the packaging is co-designed and co-manufactured along with the wafer ***,materials issues,in particular the mesoscale microstructure,have to date been excluded from the integrated product design cycle of electronic packaging due to the myriad of materials used and the complex nature of the material phenomena that require a multiphysics approach to *** the context of the materials genome initiative,we present an overview of a series of studies that aim to establish the linkages between the material microstructure and its responses by considering the multiple perspectives of the various multiphysics *** microstructure was predicted using thermodynamic calculations,sharp interface kinetic models,phase field,and phase field crystal *** on the predicted mesoscale microstructure,linear elastic mechanical analyses and electromigration simulations on the ultrafine interconnects were *** microstructural index extracted by a method based on singular value decomposition exhibits a monotonous decrease with an increase in the interconnect *** artificial neural network-based fitting revealed a nonlinear relationship between the microstructure index and the average von Mises stress in the ultrafine *** work to address the randomness of microstructure and the resulting scatter in the reliability is discussed in this study.

摘要：The lifespan of biological heart valve prostheses available in the market is limited due to structural alterations caused by calcium phosphate deposits formed from blood plasma in contact with the *** objective of this work is to present a comparative methodology for the investigation of the formation of calcium phosphate deposits on bioprosthetic and tissue-engineered scaffolds in vitro and the influence of mechanical forces on tissue *** on earlier investigations on biological mineralization at constant supersaturation,a circulatory loop simulating dynamic blood flow and physiological pressure conditions was *** system was appropriately adapted to evaluate the calcification potential of decellularized(DCV)and glutaraldehyde-fixed(GAV)porcine aortic *** indicated that DCV calcified at higher,statistically nonsignificant,rates in comparison with *** difference was attributed to the tissue surface modifications and cell debris leftovers from the decellularization *** analysis of the solids deposited after 20 h by scanning electron microscopy in combination with chemical microanalysis electron-dispersive spectroscopy identified the solid formed as octacalcium phosphate(Ca8(PO4)6H2·5H2O,OCP).OCP crystallites were preferentially deposited in high mechanical stress areas of the test ***,GAV tissues developed a significant transvalvular pressure gradient increase past 36 h with a calcium deposition distribution similar to the one found in explanted *** conclusion,the presented in vitro circulatory model serves as a valuable prescreening methodology for the investigation of the calcification process of bioprosthetic and tissue-engineered valves under physiological mechanical load.

摘要：血管支架置入的介入治疗是心血管狭窄和堵塞普遍采用的治疗方法,但支架的传统制造方法如激光切割等工艺复杂且无法制造分叉支架等复杂结构,而三维(3D)打印技术为复杂结构及个性化血管支架制造提供了新的思路。本文采用3D打印技术和0~10μm的316L不锈钢粉末材料打印制作了一种新型血管支架,对打印完成的血管支架进行电解抛光以去除支架表面粘附的粉末,并对抛光后的支架进行了球囊扩张及平面压缩实验。结果表明,本文设计的新型结构血管支架可采用3D打印技术制备;电解抛光去除了粘附的粉末,使支架表面粗糙度Ra由1.36μm降低到了0.82μm;抛光后的支架在球囊压力下外径由2.42 mm扩张到3.63 mm时的轴向缩短率为4.23%,卸载后径向回弹率为2.48%;支架的径向支撑力为8.32 N。3D打印血管支架可通过电解抛光去除表面粉末改善表面质量,并具有良好的扩张表现及径向支撑性能,为3D打印血管支架的实际应用提供了参考依据。