摘要：xi'an jiaotong university (XJTU)has carded out the research of additive manufacturing (AM)since 1993,who is one of the earliest institutes majoring in *** 20years of effort,XJTU has made great progress on the additive manufacturing of polymer,metals,ceramics,composite materials and intelligent *** has established a research team that features the engineering application of rapid manufacturing system.

摘要：Based on the building principle of additive manufacturing,printing orientation mainly determines the tribological properties of joint *** this study,we created a polyether-ether-ketone(PEEK)joint prosthesis using fused filament fabrication and investigated the effects of printing orientation on its tribological properties using a pin-on-plate tribometer in 25% newborn calf *** ultrahigh molecular weight polyethylene transfer film is formed on the surface of PEEK due to the mechanical capture of wear debris by the 3D-printed groove morphology,which is significantly impacted by the printing orientation of *** the printing orientation was parallel to the sliding direction of friction,the number and size of the transfer film increased due to higher steady *** transfer film protected the matrix and reduced the friction coefficient and wear rate of friction pairs by 39.13%and 74.33%,***,our findings provide a novel perspective regarding the role of printing orientation in designing knee prostheses,facilitating its practical applications.

摘要：Hypoxia is a typical feature of the tumor microenvironment,one of the most critical factors affecting cell behavior and tumor ***,the lack of tumor models able to precisely emulate natural brain tumor tissue has impeded the study of the effects of hypoxia on the progression and growth of tumor *** study reports a three-dimensional(3D)brain tumor model obtained by encapsulating U87MG(U87)cells in a hydrogel containing type I *** also documents the effect of various oxygen concentrations(1%,7%,and 21%)in the culture environment on U87 cell morphology,proliferation,viability,cell cycle,apoptosis rate,and ***,it compares two-dimensional(2D)and 3D *** comparison purposes,cells cultured in flat culture dishes were used as the control(2D model).Cells cultured in the 3D model proliferated more slowly but had a higher apoptosis rate and proportion of cells in the resting phase(G0 phase)/gap I phase(G1 phase)than those cultured in the 2D ***,the two models yielded significantly different cell ***,hypoxia(e.g.,1%O2)affected cell morphology,slowed cell growth,reduced cell viability,and increased the apoptosis rate in the 3D *** results indicate that the constructed 3D model is effective for investigating the effects of biological and chemical factors on cell morphology and function,and can be more representative of the tumor microenvironment than 2D culture *** developed 3D glioblastoma tumor model is equally applicable to other studies in pharmacology and pathology.

摘要：The utilization of prefabricated light modular radiant heating system has demonstrated significant increases in heat transfer efficiency and energy conservation *** prefabricated building construction,this new heating method presents an opportunity for the development of comprehensive *** parameters for evaluating the effectiveness of such a system are the upper surface layer’s heat flux and *** this paper,thermal resistance analysis calculation based on a simplified model for this unique radiant heating system analysis is presented with the heat transfer mechanism’s *** results obtained from thermal resistance analysis calculation and numerical simulation indicate that the thermal resistance analysis method is highly accurate with temperature discrepancies ranging from 0.44℃ to−0.44℃ and a heat flux discrepancy of less than 7.54%,which can meet the requirements of practical engineering applications,suggesting a foundation for the prefabricated radiant heating system.

摘要：This paper presents an aerodynamic optimum design method for transonic turbine cascades based on the Genetic Algorithms coupled to the inviscid flow Euler solver and the boundary-layer *** Genetic Algorithms control the evolution of a population of cascades towards an optimum *** fitness value of each string is evaluated using the flow solver. The design procedur6 has been developed and the behavior of the genetic algorithms has been tested. The objective functions of the design examples are the minimum mean-square deviation between the aimed pressure and computed pressure and the minimum amount of user expertise.

摘要：设计和制备具有优异防污能力的可注射防粘连材料对预防手术后组织和器官的粘连具有重要的意义.在此,我们将含有羟基的氨基酸衍生物引入水凝胶的制备中,通过N-丙烯酰丝氨酸(ASer)的自由基聚合制备了一种新型的氢键交联水凝胶(PASer).结果发现一个甲基取代基的存在会对分子间氢键相互作用产生明显的影响:与聚(N-丙烯酰苏氨酸)(PAThr)水凝胶相比,PASer水凝胶具有较低的成胶浓度和增强的力学性能.值得一提的是,亲水性羟基使PASer水凝胶能够有效抵抗蛋白质吸附和细胞粘附.PASer水凝胶具有优异的力学性能、可注射性、自融合性、良好的生物相容性和适宜的体内停留时间,符合临床对术后抗粘连材料的要求.体内研究实验结果表明,PASer水凝胶在建立的小鼠腹壁缺损模型中可以有效预防术后腹膜粘连发生.

摘要：聚环氧乙烷(PEO)聚合物电解质有望应用于全固态锂金属电池.然而,目前还没有提出有效的方法制备全固态PEO电解质,以克服其在室温下无法使用的局限性.在本研究中,我们基于聚合物C-H键功能化策略,通过在聚合物链上直接共价连接具有锂配位活性的丁二腈官能团,设计出了一种高离子导电性PEO电解质.该官能团有效增强了PEO链的无序性和流动性,同时也作为链间快速离子传导的活性位点,从而实现了离子周围自由体积和迁移行为的双重优化.得益于官能团对离子输运的精准调节,新型电解质表现出更强的离子传导性(离子电导率提升100倍)、更高的转移数(tLi+=0.51)和更宽的电化学窗口(>0.47 V).特别是功能化的PEO300k电解质具有超高室温离子电导率(25℃时为1.01×10^(-4)S cm^(-1))并且能够在室温下稳定工作,该研究为开发具有实际应用价值的聚合物电解质提供了新的途径.

摘要：具有随机孔隙的多孔泡沫在声音管理应用中得到越来越多的利用,其吸声系数通常作为性能评估和设计优化的关键声学参数.根据不同的加工方法,泡沫中的孔隙可以是全开或半开的,并且通常表现为分形分布特征.为了便于工程应用,有必要对这些泡沫的吸声系数进行分析预测.然而,分析预测泡沫的吸声系数是一个挑战.因此,本研究提出了半开孔和全开孔的简化代表结构来微观分析泡沫内部的流动特性,并应用分形理论来描述随机分布的孔隙.引入一个叫“开孔度”的参数来表征孔隙的开放程度,可以解析地获得代表结构的粘性和热特征长度.随后,在经典吸声系数Johnson-Champoux-Allard模型的基础上,建立了一种将代表结构与分形理论统一起来的解析模型,从而可以将吸声系数作为具有全开/半开孔泡沫的关键形态参数的函数进行预测.与已有的实验测量和数值模拟结果相比,本文提出的分析模型可以较好地预测了半开孔和全开孔泡沫的关键流动特性和吸声系数.在0到4500 Hz的频率范围内,半开孔泡沫相对于具有相同孔隙率的全开孔泡沫可以更好地衰减声波.在孔隙率为0.95的条件下,半开孔泡沫的总体吸声系数分别提高了21.2%、57.7%和75.8%,此时开孔度由0.75到0.50降低了0.25.

摘要：Based on a theoretical motion equation of encapsulated microbubbles within an ultrasound field, the subharmonic characterizations of microbubbles are optimally designed and analyzed by a computer aided design system. The effects of size, shell elasticity and acoustic pressure on subharmonic response of microbubbles are calculated theoretically to obtain the optimal parameters for nondestructive subharmonic imaging. In addition, microbubbles with different shell elasticity are prepared, and their subharmonic responses are measured in vitro. The results of theoretical calculation and acoustic measurement show that good subharmonic enhancement can be obtained by using the encapsulated microbubbles with the mean size of 3 μm, which were prepared from the surfactant solution with the proper ratio of shell material. It is also shown that the best operating acoustic pressure is 200 to 400 kPa for nondestructive subharmonic imaging based on such kind of microbubbles.

摘要：Bioprinting has been widely investigated for tissue engineering and regenerative medicine ***,it is still difficult to reconstruct the complex native cell arrangement due to the limited printing resolution of conventional bioprinting techniques such as extrusion-and inkjet-based ***,an electrohydrodynamic(EHD)bioprinting strategy was reported for the precise deposition of well-organized cell-laden constructs with microscale filament size,whereas few studies have been devoted to developing bioinks that can be applied for EHD bioprinting and simultaneously support cell *** study describes functionalized alginate-based bioinks for microscale EHD bioprinting using peptide grafting and fibrin incorporation,which leads to high cell viability(>90%)and cell *** printed filaments can be further refined to as small as 30μm by incorporating polyoxyethylene and remained stable over one week when exposed to an aqueous *** utilizing the presented alginate-based bioinks,layer-specific cell alignment along the printing struts could be observed inside the EHD-printed microscale filaments,which allows fabricating living constructs with cell-scale filament resolution for guided cellular orientation.