摘要：Injection therapy for diabetes has poor patient compliance,and the pain occurring at the site of subcutaneous injections causes significant inconvenience to diabetic *** this work,to demonstrate the benefits of an alternative drug delivery technique that overcomes these issues,methacrylated gelatin hydrogel-forming microneedles integrated with metformin were developed to adjust blood glucose levels in diabetic *** methacryloyl microneedles(GelMA-MNs)with different degrees of substitution were successfully prepared by a micro-molding *** resultant GelMA-MNs exhibited excellent mechanical properties and moisture ***,an anti-diabetic drug,was further encapsulated into the GelMA-MNs,and its release rate could be controlled by the three-dimensional cross-linked network of microneedles,thereby exhibiting sustained drug release behaviors in vitro and implying a better therapeutic effect compared with that of subcutaneous injection in diabetic *** drug release period could be significantly prolonged by improving the cross-link density of *** results of hypoglycemic effect evaluation show that the application of GelMA-MNs for transdermal delivery in diabetic rats has promising benefits for diabetes treatment.

摘要：We present a semi-custom design methodology based on transistor tuning to optimize the design performance. Compared with other transistor tuning approaches, our tuning process takes the cross-talk effect into account and prominently reduces the complexity for circuit simulation and analysis by decomposing the circuit network utilizing graph theory. Furthermore, the incremental placement and routing for the corresponding transistor tuning in conventional approaches is not required in our methodology, which might induce timing graph variation and additional iterations for design convergence. This methodology combines the flexible automated circuit tuning and physical design tools to provide more opportunities for design optimization throughout the design cycle.

摘要：Aiming at reducing the difficulty of cooling the interior of high-density motors,this study proposed the placement of a water cold plate cooling structure between the axial laminations of the motor *** effect of the cooling water flow,thickness of the plate,and motor loss density on the cooling effect of the water cold plate were *** compare the cooling performance of water cold plate and outer spiral water jacket cooling structures,a high-speed permanent magnet motor with a high loss density was used to establish two motor models with the two cooling ***,the cooling effects of the two models were analyzed using the finite element method under the same loss density,coolant flow,and main *** results were as follows.(1)The maximum and average temperatures of the water cold plate structure were reduced by 25.5%and 30.5%,respectively,compared to that of the outer spiral water jacket motor;(2)Compared with the outer spiral water jacket structure,the water cold plate structure can reduce the overall mass and volume of the *** a 100 kW high-speed permanent magnet motor as an example,a water cold plate cooling system was designed,and the temperature distribution is analyzed,with the result indicating that the cooling structure satisfied the cooling requirements of the high loss density motor.

摘要：pH-sensitive smart polymeric nanocarriers have been under development in the field ofbiomedicine due to permeabilization the physiological barriers readily to address the limitation of conventional chemotherapeutics delivery systems of low intracellular transport and targeting *** traditional polymers kept stable under physiological neutral or acidic conditions,pH-sensitive polymeric nanocarriers underwent rapid degradation with a labile group in tumor acidic environment(around 5.0-6.0),allowing these biomaterials to achieve controlled drug release,drug pharmacokinetics improvement and antitumor biotherapeutic molecules efficiency enhancement compared with traditional *** review mainly concentrated on properties of pH-sensitive polymers for biomedical purposes to construct the smart drug delivery system based on acid liable linkers which were categorized into pH-sensitive polymeric prodrugs composed of antitumor drugs(doxorubicin and paclitaxel)bounded to the polymer via acid liable linkers and pH-sensitive copolymeric nanocarriers prepared by block copolymers containing polymer blocks linked with acid-cleavable ***,advanced platforms in biomedicine for special biotherapeutic molecules delivery were reviewed in the ***,several acid-sensitive linkages were reviewed to study the mechanism of the controlled pH-responsive drug delivery,such as hydrazone,acetal,cis-aconityl linker and β-thioether ester,as well as improvement of drug pharmacokinetics.

摘要：一个万用的金属器官的化学蒸汽免职(MOCVD ) 系统被设计并且构造。铜电影在硅(100 ) 上被扔由用 Cu (hfac )2 的化学蒸汽免职(CVD ) 的底层作为一位先锋。由 Cu (hfac )2 的 H 2 减小的硅底层上的 Cu 原子核的生长被原子力量显微镜学和扫描电子显微镜学学习。Cu 原子核的生长模式是开始 Volmer 网模式(岛) ，然后到 Stranski-Rastanov 模式(加岛的 layer-by-layer ) 的变换。硅(100 ) 上的 Cu 成核的机制底层被 X 光检查光电子进一步调查光谱学。从 Cu2p， O1s， F1s， Si2p 模式，观察 C=O，哦并且 CF 3/CF2 应该属于 Cu (hfac )2 的热分离形成的 Cu (hfac ) 。H 2 在表面上与 hfac 反应，生产哦。与它的累积，哦与 hfac 反应，形成 HO-hfac，并且同时，使放出铜氧化物被减少，并且因此，在 Cu (hafc )2 之间的氧化还原作用反应和 H 2 发生。

摘要：For accurate prediction of via yield, via chains are usually fabricated on test chips to investigate issues about vias. To minimize the randomness of experiments and make the testing results more convincing, the confidence level and estimation precision of the via failure rate are investigated in this paper. Based on the Poisson yield model, the method of determining an adequate number of total vias is obtained using the law of large numbers and the de Moivre-Laplace theorem. Moreover, for a specific confidence level and estimation precision, the method of determining a suitable via chain length is proposed. For area minimization, an optimal combination of total vias and via chain length is further determined. Monte Carlo simulation results show that the method is in good accordance with theoretical analyses. Results of via failure rates measured on test chips also reveal that via chains designed using the proposed method has a better performance. In addition, the proposed methodology can be extended to investigate statistical significance for other failure modes.

摘要：This paper presents some techniques for synthesizing novel view for a virtual viewpoint from two given views cap-tured at different viewpoints to achieve both high quality and high efficiency. The whole process consists of three passes. The first pass recovers depth map. We formulate it as pixel labelling and propose a bisection approach to solve it. It is accomplished in log2n(n is the number of depth levels) steps,each of which involves a single graph cut computation. The second pass detects occluded pixels and reasons about their depth. It fits a foreground depth curve and a background depth curve using depth of nearby fore-ground and background pixels,and then distinguishes foreground and background pixels by minimizing a global energy,which involves only one graph cut computation. The third pass finds for each pixel in the novel view the corresponding pixels in the input views and computes its color. The whole process involves only a small number of graph cut computations,therefore it is efficient. And,visual artifacts in the synthesized view can be removed successfully by correcting depth of the occluded pixels. Experimental results demonstrate that both high quality and high efficiency are achieved by the proposed techniques.

摘要：The potential role of formal structural optimization was investigated for designing foldable and deployable structures in this ***-sizing nested optimization is a challenging design ***,represented by the lengths and relative angles of elements,is critical to achieving smooth deployment to a desired span,while the section profiles of each element must satisfy structural dynamic performances in each deploying *** characteristics of deployable structures in the initial state,the final state and also the middle deploying states are all crucial to the structural dynamic *** shape was represented by the nodal coordinates and the profiles of cross sections were represented by the diameters and ***(sequential quadratic programming) method was used to explore the design space and identify the minimum mass solutions that satisfy kinematic and structural dynamic *** optimization model and methodology were tested on the case-study of a deployable *** strategy can be easily extended to design a wide range of deployable structures,including deployable antenna structures,foldable solar sails,expandable bridges and retractable gymnasium roofs.

摘要：Compression is an intuitive way to boost the performance of a database system. However, compared with other physical database design techniques, compression consumes large amount of CPU power. There is a trade-off between the re- duction of disk access and the overhead of CPU processing. Automatic design and adaptive administration of database systems are widely demanded, and the automatic selection of compression schema to compromise the trade-off is very important. In this paper, we present a model with novel techniques to integrate a rapidly convergent agent-based evolution framework, i.e. the SWAF (SWarm Algorithm Framework), into adaptive attribute compression for relational database. The model evolutionally consults statistics of CPU load and IO bandwidth to select compression schemas considering both aspects of the trade-off. We have im- plemented a prototype model on Oscar RDBMS with experiments highlighting the correctness and efficiency of our techniques.

摘要：A monolithic optoelectronic integrated circuit chip on a silicon-on-insulator is designed and fabricated based on complementary metal oxide semiconductor compatible *** chip integrates an optical Mach-Zehnder modulator (MZM) and a CMOS driving circuit with the amplification *** results show that the extinction ratio of the MZM is close to 20dB and the small-signal gain of the CMOS driving circuit is about 26.9dB.A 50m V 10 MHz sine wave signal is amplified by the driving circuit,and then drives the MZM successfully.